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Mayo Clinic clinical trial failures
Review 168 stopped clinical trials from Mayo Clinic, including disease areas, phases, and classified stop reasons.
This page groups real ClinicalTrials.gov-derived stopped trial records. The strongest added signal is the stop-reason classification: 8 of these records are likely biological failure signals, while the rest may reflect operational, strategic, regulatory, funding, enrollment, or unclear stop reasons.
Dominant stop reasons
- OPERATIONAL
- 109
- OTHER/UNKNOWN
- 51
- EFFICACY/FUTILITY
- 4
- SAFETY
- 4
Notable sponsors
- Mayo Clinic
- 168
Related phases
- Phase II
- 65
- Phase I
- 53
- Phase IV
- 20
- Unknown
- 12
- Phase III
- 10
Crawlable stopped-trial records
Open ExploreShowing up to 100 representative records from this slice. Each link opens the trial detail page with source attribution and stop-reason context.
Early Phase I End Stage Renal Disease trial by Mayo Clinic. Stop reason: OPERATIONAL.
Unable to enroll patients for the trial.
Phase II Crohn Disease trial by Mayo Clinic. Stop reason: OPERATIONAL.
Sponsor discontinued placebo. Unable to meet enrollment goals.
Phase II Metastatic Pancreatic Adenocarcinoma trial by Mayo Clinic. Stop reason: OPERATIONAL.
Low/slow accrual
Phase II Breast Cancer trial by Mayo Clinic. Stop reason: OPERATIONAL.
slow accrual; insufficient funding to continue to accrue
Phase IV Peripheral Arterial Disease trial by Mayo Clinic. Stop reason: OPERATIONAL.
Lack of funds
Phase II Chronic Graft Versus Host Disease trial by Mayo Clinic. Stop reason: OPERATIONAL.
poor accrual
Phase IV Pain Control trial by Mayo Clinic. Stop reason: SAFETY.
Study participant had a related adverse event that prompted interim data analysis and additional study participants were not sought.
Phase II Granulomatosis With Polyangiitis trial by Mayo Clinic. Stop reason: OPERATIONAL.
Funding was withdrawn by sponsor.
Phase II Recurrent Waldenstrom Macroglobulinemia trial by Mayo Clinic. Stop reason: EFFICACY/FUTILITY.
Discontinued after interim analysis for futility; no treatment successes observed in the first 12 patients
Phase II Pancreatic Diseases trial by Mayo Clinic. Stop reason: EFFICACY/FUTILITY.
study paused for interim analysis
Phase I Lung Non-Small Cell Carcinoma trial by Mayo Clinic. Stop reason: OPERATIONAL.
slow accrual
Phase II Chronic Kidney Diseases trial by Mayo Clinic. Stop reason: OPERATIONAL.
Due to lack of funding
Phase I Clinical Stage III Cutaneous Melanoma AJCC v8 trial by Mayo Clinic. Stop reason: OPERATIONAL.
Lack of funding; lack of objective response
Phase II Breast Atypical Hyperplasia trial by Mayo Clinic. Stop reason: OPERATIONAL.
grant and funding expired
Phase II Recurrent Chronic Lymphocytic Leukemia trial by Mayo Clinic. Stop reason: OPERATIONAL.
Slow accrual
Phase I Advanced Cholangiocarcinoma trial by Mayo Clinic. Stop reason: OPERATIONAL.
study sponsor phasing out drug supply
Phase IV Pancreaticoduodenectomy trial by Mayo Clinic. Stop reason: OPERATIONAL.
Low accrual
Phase II Fallopian Tube Carcinosarcoma trial by Mayo Clinic. Stop reason: OPERATIONAL.
poor accrual
Phase I Clinical Stage III Cutaneous Melanoma AJCC v8 trial by Mayo Clinic. Stop reason: OPERATIONAL.
low/slow accrual
Phase II Advanced Lung Non-Small Cell Carcinoma trial by Mayo Clinic. Stop reason: OTHER/UNKNOWN.
EMD Serono recommendation based on three other studies that failed to show benefit for bintrafusp alfa
Phase II Anatomic Stage I Breast Cancer AJCC v8 trial by Mayo Clinic. Stop reason: OTHER/UNKNOWN.
The primary biomarker (CD8/FOXP3) was rarely observed to be \< 1.6 in residual tumors examined in first stage of study.
Phase II Primary Myelofibrosis trial by Mayo Clinic. Stop reason: OTHER/UNKNOWN.
Study drug became commercially available
Phase I Malignant Central Nervous System Neoplasm trial by Mayo Clinic. Stop reason: OPERATIONAL.
Funding issues
Phase II Liver Transplant trial by Mayo Clinic. Stop reason: OPERATIONAL.
Low Enrollment
Phase II Anatomic Stage I Breast Cancer AJCC v8 trial by Mayo Clinic. Stop reason: OPERATIONAL.
slow accrual
Phase II Covid19 trial by Mayo Clinic. Stop reason: EFFICACY/FUTILITY.
The DSMB and NIA determined the study should be stopped due to futility.
Phase II Plasma Cell Myeloma trial by Mayo Clinic. Stop reason: OPERATIONAL.
slow accrual
Phase I Clinical Stage IV Cutaneous Melanoma AJCC v8 trial by Mayo Clinic. Stop reason: OPERATIONAL.
Financial issues
Phase I Recurrent Plasma Cell Myeloma trial by Mayo Clinic. Stop reason: OTHER/UNKNOWN.
Drug company decided to not fund the phase 2 portion
Phase I Diabetic Kidney Disease trial by Mayo Clinic. Stop reason: OTHER/UNKNOWN.
Principal Investigator relocation
Phase I Clinical Stage IV Cutaneous Melanoma AJCC v8 trial by Mayo Clinic. Stop reason: OPERATIONAL.
Lack of funding
Phase III Ann Arbor Stage I Grade 1 Follicular Lymphoma trial by Mayo Clinic. Stop reason: OPERATIONAL.
drug supply issues
Phase I Stage III Cutaneous Melanoma AJCC v7 trial by Mayo Clinic. Stop reason: OPERATIONAL.
poor accrual
Phase I Breast Adenocarcinoma trial by Mayo Clinic. Stop reason: OPERATIONAL.
funding - sponsor filing Chapter 11 bankruptcy
Phase I Plasma Cell Myeloma trial by Mayo Clinic. Stop reason: OPERATIONAL.
Low/slow accrual - did not proceed to Phase 2
Phase II Ovarian Serous Tumor trial by Mayo Clinic. Stop reason: EFFICACY/FUTILITY.
The study is closed per results from the interim analysis.
Phase IV Advanced Malignant Solid Neoplasm trial by Mayo Clinic. Stop reason: OPERATIONAL.
low/slow accrual
Phase II Pmm2-CDG trial by Mayo Clinic. Stop reason: OPERATIONAL.
Lack of funding
Phase I GAD 65 Antibody-associated Epilepsy trial by Mayo Clinic. Stop reason: OPERATIONAL.
Study population was difficult to identify for enrollment interest.
Phase II Diabetic Polyneuropathy trial by Mayo Clinic. Stop reason: OPERATIONAL.
no participants enrolled
Early Phase I Malignant Abdominal Neoplasm trial by Mayo Clinic. Stop reason: OPERATIONAL.
slow accrual
Phase I Metastatic Pancreatic Adenocarcinoma trial by Mayo Clinic. Stop reason: OPERATIONAL.
lack of funding
Phase I Advanced Malignant Solid Neoplasm trial by Mayo Clinic. Stop reason: OTHER/UNKNOWN.
Sponsor business considerations
Phase I Clinical Stage III Cutaneous Melanoma AJCC v8 trial by Mayo Clinic. Stop reason: OPERATIONAL.
Lack of funding
Unknown Skin Cancer trial by Mayo Clinic. Stop reason: OPERATIONAL.
Lack of resources to support the trial
Phase I Eosinophilic Fasciitis trial by Mayo Clinic. Stop reason: OPERATIONAL.
Funding lost from Sponsor.
Phase I Skin Aging trial by Mayo Clinic. Stop reason: OTHER/UNKNOWN.
Principal Investigator discretion
Phase II Myelodysplastic/Myeloproliferative Neoplasm With Ring Sideroblasts and Thrombocytosis, Not Otherwise Specified trial by Mayo Clinic. Stop reason: OPERATIONAL.
Slow accrual
Phase III Postoperative Urinary Retention trial by Mayo Clinic. Stop reason: OPERATIONAL.
Slow recruitment and enrollment
Phase IV Sleep Disorder trial by Mayo Clinic. Stop reason: OPERATIONAL.
Change in personnel and lack of resources to continue.
Phase II Hepatopulmonary Syndrome trial by Mayo Clinic. Stop reason: OPERATIONAL.
Low Recruitment Numbers
Phase III Advanced Malignant Solid Neoplasm trial by Mayo Clinic. Stop reason: OPERATIONAL.
Closed due to slow accrual
Phase I Hypertrophic Scar trial by Mayo Clinic. Stop reason: OPERATIONAL.
Funding changes.
Unknown Peyronie Disease trial by Mayo Clinic. Stop reason: OPERATIONAL.
No participants enrolled
Phase I Anatomic Stage I Breast Cancer AJCC v8 trial by Mayo Clinic. Stop reason: OPERATIONAL.
poor accrual
Phase II Stage 0a Renal Pelvis and Ureter Cancer AJCC v8 trial by Mayo Clinic. Stop reason: OTHER/UNKNOWN.
Focus research efforts on other projects.
Phase IV Gastric Cancer trial by Mayo Clinic. Stop reason: OPERATIONAL.
Lack of funding.
Phase IV Intractable Epilepsy trial by Mayo Clinic. Stop reason: OPERATIONAL.
The funding sponsor, EISAI, sold the US rights to the medication and can no longer provide it to patients for the study.
Phase II Iron-deficiency trial by Mayo Clinic. Stop reason: OPERATIONAL.
Unable to recruit participants
Phase II Breast Carcinoma trial by Mayo Clinic. Stop reason: OPERATIONAL.
Administratively closed due to low/no accrual
Phase II Vasoplegic Syndrome trial by Mayo Clinic. Stop reason: OPERATIONAL.
Insufficient recruitment over study period
Phase I Prostate Cancer trial by Mayo Clinic. Stop reason: OPERATIONAL.
closed early due to poor accrual
Phase I Tracheoesopharyngeal Fistula trial by Mayo Clinic. Stop reason: OPERATIONAL.
Study closed due to lack of patient enrollment.
Phase I Hypertension, Resistant to Conventional Therapy trial by Mayo Clinic. Stop reason: SAFETY.
Study was withdrawn and replaced by a larger study
Phase II Hemicrania Continua trial by Mayo Clinic. Stop reason: OPERATIONAL.
difficulty with recruitment
Early Phase I Vaping trial by Mayo Clinic. Stop reason: OTHER/UNKNOWN.
medication has not been available for the intervention
Phase I Mesothelin Positive trial by Mayo Clinic. Stop reason: OPERATIONAL.
slow accrual
Early Phase I Anatomic Stage III Breast Cancer AJCC v8 trial by Mayo Clinic. Stop reason: OTHER/UNKNOWN.
study was dropped
Phase I Multiple Myeloma trial by Mayo Clinic. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase II Eosinophilic Esophagitis trial by Mayo Clinic. Stop reason: OPERATIONAL.
low enrollment
Phase IV Healthy trial by Mayo Clinic. Stop reason: OTHER/UNKNOWN.
Newly available data suggests that measuring proinsulin clearance would not enhance predictive value of serum proinsulin
Phase II Cardiac Disease trial by Mayo Clinic. Stop reason: OTHER/UNKNOWN.
Patient population changed and no subjects eligible for the study.
Unknown Hodgkin Lymphoma trial by Mayo Clinic. Stop reason: OPERATIONAL.
no patients enrolled
Phase II Aging trial by Mayo Clinic. Stop reason: OPERATIONAL.
difficult recruitment and not achieved
Phase IV Healthy trial by Mayo Clinic. Stop reason: OTHER/UNKNOWN.
results from other study suggest no good reason to proceed
Phase I Acute Pancreatitis trial by Mayo Clinic. Stop reason: OPERATIONAL.
Difficult recruitment
Phase IV Enteropathy trial by Mayo Clinic. Stop reason: OPERATIONAL.
Study recruitment was difficult and not acheived
Phase I Peripheral Arterial Disease trial by Mayo Clinic. Stop reason: OPERATIONAL.
Unable to enroll subjects
Early Phase I Systemic Lupus Erythematosus trial by Mayo Clinic. Stop reason: OPERATIONAL.
Difficulty with enrollment
Phase I Pre-Diabetic trial by Mayo Clinic. Stop reason: OPERATIONAL.
Difficulty with study logistics due to COVID-19
Phase II Cadasil trial by Mayo Clinic. Stop reason: OPERATIONAL.
Lack of funding to support the trial.
Phase I Status Migrainosus trial by Mayo Clinic. Stop reason: OPERATIONAL.
No Participants Enrolled
Phase I Degenerative Disc Disease trial by Mayo Clinic. Stop reason: OTHER/UNKNOWN.
Principal Investigator transition
Unknown Hypertrophic Cardiomyopathy trial by Mayo Clinic. Stop reason: OTHER/UNKNOWN.
The decision was made by study team to pursue this as a quality project instead.
Phase I Osteonecrosis trial by Mayo Clinic. Stop reason: OPERATIONAL.
Logistical delays from device manufacturer due to COVID
Phase IV Achalasia trial by Mayo Clinic. Stop reason: OPERATIONAL.
Unable to recruit participants.
Phase IV Crohn Disease trial by Mayo Clinic. Stop reason: OPERATIONAL.
Unable to secure funding.
Phase II Lymphocytic Colitis trial by Mayo Clinic. Stop reason: OPERATIONAL.
Study closed early, because of low enrollment.
Phase IV Vaginal Hysterectomy trial by Mayo Clinic. Stop reason: OPERATIONAL.
Insufficient funding to continue with study activities
Phase II Obesity trial by Mayo Clinic. Stop reason: OPERATIONAL.
Lorcaserin removed from market
Phase IV Metabolic Acidosis trial by Mayo Clinic. Stop reason: OTHER/UNKNOWN.
Due to the fact that we were unable to find subjects who met all inclusion and exclusion criteria it was determined to withdraw this study.
Phase III Atrial Fibrillation trial by Mayo Clinic. Stop reason: OPERATIONAL.
Study terminated due to slower than anticipated enrollment.
Phase II Monoclonal B-Cell Lymphocytosis trial by Mayo Clinic. Stop reason: OPERATIONAL.
Slow Accrual
Phase II Ovarian Cancer trial by Mayo Clinic. Stop reason: OPERATIONAL.
Accrual temporarily suspended, followed by study closure due to technical problems with investigational camera.
Unknown Acute DVT of Lower Extremity trial by Mayo Clinic. Stop reason: OPERATIONAL.
Due to lack of recruitment of eligible participants
Unknown Colonoscopy trial by Mayo Clinic. Stop reason: OPERATIONAL.
Lack of enrollment
Phase I Recurrent Chronic Lymphocytic Leukemia trial by Mayo Clinic. Stop reason: OPERATIONAL.
Lack of funding
Phase II Landau-Kleffner Syndrome trial by Mayo Clinic. Stop reason: OPERATIONAL.
Lack of enrollment
Phase I Fibromuscular Dysplasia of Arteries trial by Mayo Clinic. Stop reason: OTHER/UNKNOWN.
Closed by Investigator
Phase II Blastic Plasmacytoid Dendritic Cell Neoplasm trial by Mayo Clinic. Stop reason: OTHER/UNKNOWN.
due to poor response