Phase hub
Early Phase I clinical trial failures
Explore 614 stopped early phase i clinical trials with sponsors, indications, and stop-reason signals.
This page groups real ClinicalTrials.gov-derived stopped trial records. The strongest added signal is the stop-reason classification: 14 of these records are likely biological failure signals, while the rest may reflect operational, strategic, regulatory, funding, enrollment, or unclear stop reasons.
Dominant stop reasons
- OPERATIONAL
- 347
- OTHER/UNKNOWN
- 250
- EFFICACY/FUTILITY
- 8
- SAFETY
- 6
- REGULATORY
- 3
Notable sponsors
- Wake Forest University Health Sciences
- 14
- Yale University
- 14
- M.D. Anderson Cancer Center
- 12
- Johns Hopkins University
- 10
- University of Alabama at Birmingham
- 10
Related phases
- Early Phase I
- 614
Crawlable stopped-trial records
Open ExploreShowing up to 100 representative records from this slice. Each link opens the trial detail page with source attribution and stop-reason context.
Early Phase I Opioid Use Disorder trial by Jacques E. Chelly. Stop reason: OPERATIONAL.
Study did not receive funding.
Early Phase I Epidural Spinal Tumors trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
Low accruals
Early Phase I End Stage Renal Disease trial by Mayo Clinic. Stop reason: OPERATIONAL.
Unable to enroll patients for the trial.
Early Phase I Bariatric Surgery Candidate trial by McMaster University. Stop reason: OPERATIONAL.
No funding available.
Early Phase I Rheumatoid Arthritis trial by Institute of Hematology & Blood Diseases Hospital, China. Stop reason: OPERATIONAL.
Due to the sponsor's adjustment of the research and development strategy for this clinical trial, this study was prematurely terminated, and no subjects were recruited for this study
Early Phase I Systemic Sclerosis (SSc) trial by RenJi Hospital. Stop reason: OTHER/UNKNOWN.
company's decision
Early Phase I Brain Tumor trial by University of Rochester. Stop reason: OPERATIONAL.
lack of enrollment
Early Phase I Exocrine Pancreatic Cancer trial by University of Oklahoma. Stop reason: OTHER/UNKNOWN.
Translational scientist left university
Early Phase I Breast Cancer trial by Stanford University. Stop reason: OPERATIONAL.
Awaiting more funding to build a more stable technology.
Early Phase I Systemic Lupus Erythematosus trial by The Affiliated Hospital of Xuzhou Medical University. Stop reason: OTHER/UNKNOWN.
Internal decision.
Early Phase I Leukemia trial by Guangzhou Bio-gene Technology Co., Ltd. Stop reason: OTHER/UNKNOWN.
Due to corporate strategic adjustment.
Early Phase I Multiple Myeloma Refractory trial by Guangzhou Bio-gene Technology Co., Ltd. Stop reason: OTHER/UNKNOWN.
Due to corporate strategic adjustment.
Early Phase I Hair Loss trial by Guangzhou Bio-gene Technology Co., Ltd. Stop reason: OTHER/UNKNOWN.
Per updated regulatory requirements, the site is ineligible to proceed. The clinical institution office has terminated the project.
Early Phase I B Acute Lymphoblastic Leukemia/Lymphoma trial by Guangzhou Bio-gene Technology Co., Ltd. Stop reason: OTHER/UNKNOWN.
Due to corporate strategic adjustment.
Early Phase I Pancreatic Ductal Adenocarcinoma trial by M.D. Anderson Cancer Center. Stop reason: OPERATIONAL.
PI request
Early Phase I High Grade Glioma trial by Nader Sanai. Stop reason: OTHER/UNKNOWN.
Study terminated due to unavailability of the investigational product required to continue the study.
Early Phase I Clear Cell Renal Cell Carcinoma (ccRCC) trial by Kousai Bio Co., Ltd.. Stop reason: OTHER/UNKNOWN.
Due to a strategic adjustment, the company has decided to terminate the project.
Early Phase I Childhood CNS Tumor trial by SynerGene Therapeutics, Inc.. Stop reason: OPERATIONAL.
The grant intended to support this trial as ultimately not funded. This trial was not initiated,. No patients were enrolled.
Early Phase I B Cell Lymphoma trial by Wondercel Biotech (ShenZhen). Stop reason: OTHER/UNKNOWN.
Because the implementation of the new regulation policy by the Chinese authority
Early Phase I Multiple Myleoma trial by Wondercel Biotech (ShenZhen). Stop reason: OTHER/UNKNOWN.
Because the implementation of the new regulation policy by the Chinese authority
Early Phase I HCC - Hepatocellular Carcinoma trial by Wondercel Biotech (ShenZhen). Stop reason: OTHER/UNKNOWN.
Because the implementation of the new regulation policy by the Chinese authority
Early Phase I CRC (Colorectal Cancer) trial by Wondercel Biotech (ShenZhen). Stop reason: OTHER/UNKNOWN.
Because the implementation of the new regulation policy by the Chinese authority
Early Phase I CRC (Colorectal Cancer) trial by Wondercel Biotech (ShenZhen). Stop reason: OTHER/UNKNOWN.
Because the implementation of the new regulation policy by the Chinese authority
Early Phase I Gliosarcoma trial by Emory University. Stop reason: OPERATIONAL.
Review of Drug Supply
Early Phase I Adult trial by Grit Biotechnology. Stop reason: OTHER/UNKNOWN.
The study was terminated from a business perspective.
Early Phase I Solid Tumor trial by Grit Biotechnology. Stop reason: OTHER/UNKNOWN.
The study was terminated from a business perspective.
Early Phase I Solid Tumor Cancer trial by Thomas Hope. Stop reason: OPERATIONAL.
Sponsor funding
Early Phase I Adult Gynecological Tumors trial by Grit Biotechnology. Stop reason: OTHER/UNKNOWN.
The study was terminated from a business perspective.
Early Phase I Colorectal Cancer trial by Stephan Rogalla. Stop reason: OPERATIONAL.
The drug supply expired and the sponsor is unable to provide an updated supply.
Early Phase I Cocaine Use Disorder trial by University of California, Los Angeles. Stop reason: OTHER/UNKNOWN.
Departmental support
Early Phase I Stage I Non-Small Cell Lung Cancer AJCC v7 trial by Roswell Park Cancer Institute. Stop reason: OPERATIONAL.
low accrual
Early Phase I Vestibular Migraine trial by Vanderbilt University Medical Center. Stop reason: OPERATIONAL.
Unable to gain interest among colleagues to help recruit participants.
Early Phase I Multiple Sclerosis trial by Huashan Hospital. Stop reason: OPERATIONAL.
Due to the sponsor's adjustment of the research and development strategy for this clinical trial, this study was prematurely terminated, and no subjects were recruited for this study.
Early Phase I Multiple Sclerosis trial by University of Chicago. Stop reason: OTHER/UNKNOWN.
Study pending amendment
Early Phase I Opioid Use Disorder trial by Joshua A. Lile, Ph.D.. Stop reason: OPERATIONAL.
Funding ended
Early Phase I Posttraumatic Stress Disorder trial by University of Wisconsin, Madison. Stop reason: OPERATIONAL.
Budgeting/funding
Early Phase I Anatomic Stage IV Breast Cancer AJCC v8 trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
Low accruals
Early Phase I Demoralization trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
Sponsor terminated contract due to insufficient funding.
Early Phase I Mycosis Fungoides trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: OPERATIONAL.
Slow Accrual
Early Phase I SCI trial by VA Office of Research and Development. Stop reason: OPERATIONAL.
the study no longer has funding
Early Phase I Chronic Subdural Hematoma trial by University of New Mexico. Stop reason: OTHER/UNKNOWN.
Loss of Departmental support
Early Phase I Polycystic Ovary Syndrome trial by University of Virginia. Stop reason: OPERATIONAL.
No funding, time, or personnel to complete this study.
Early Phase I Kava trial by Masonic Cancer Center, University of Minnesota. Stop reason: OTHER/UNKNOWN.
Drug expiration testing
Early Phase I Metastatic Colon Cancer trial by Baylor Research Institute. Stop reason: OPERATIONAL.
PI-Initiated study; PI requested closure
Early Phase I Large Granular Lymphocyte Leukemia trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: EFFICACY/FUTILITY.
lack of efficacy/futility
Early Phase I Healthy trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
COVID pandemic No participant experiences (benefits, adverse events/adverse reactions)to report. There have been no safety concerns in either participant. No minor deviations to report
Early Phase I Systemic Lupus Erythematosus trial by Nanjing Bioheng Biotech Co., Ltd.. Stop reason: OTHER/UNKNOWN.
R\&D strategy adjustment
Early Phase I SLE trial by Nanjing Bioheng Biotech Co., Ltd.. Stop reason: OTHER/UNKNOWN.
R\&D strategy adjustment
Early Phase I Cervical Intraepithelial Neoplasia trial by Baylor Research Institute. Stop reason: OPERATIONAL.
no subject accrual
Early Phase I Systemic Lupus Erythematosus (SLE) trial by The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School. Stop reason: OTHER/UNKNOWN.
The collaborating party has adjusted its R\&D strategy and terminated the study.
Early Phase I Recurrent or Metastatic Solid Tumors With Positive ALPP trial by Haifeng Qin. Stop reason: OPERATIONAL.
Strategic Portfolio Decision
Early Phase I Stress Urinary Incontinence trial by Northwell Health. Stop reason: OTHER/UNKNOWN.
Principal Investigator changing locations.
Early Phase I Glioblastoma trial by Milton S. Hershey Medical Center. Stop reason: OPERATIONAL.
The study was stopped due to slow accrual.
Early Phase I Solid Tumor trial by TCRCure Biopharma Ltd.. Stop reason: OPERATIONAL.
Portfolio prioritization
Early Phase I Endodontic Disease trial by University of California, Los Angeles. Stop reason: OPERATIONAL.
Enrollment difficulties
Early Phase I Solid Tumor Cancer trial by Eben Rosenthal. Stop reason: OPERATIONAL.
No patients enrolled onto study. Administratively withdrawn.
Early Phase I Malaria, Vivax trial by University of Oxford. Stop reason: OPERATIONAL.
The study was terminated due to administrative delays in the approval of a substantial amendment to extend the shelf-life of Pvs25-IMX313. Regulatory approval was only received on 11 August 2023, after end of study visits had already been conducted.
Early Phase I Cardiovascular Diseases trial by University of Utah. Stop reason: OPERATIONAL.
COVID initially delayed plans to begin recruitment of subjects. Subsequently, the departure of a clinical investigator and loss of access to equipment and study subject population resulted in study termination before any subjects were enrolled.
Early Phase I Glioblastoma trial by Milton S. Hershey Medical Center. Stop reason: OPERATIONAL.
Enrollment was stopped due to direction from the scientific review committee of the Penn State Cancer Institute. The instruction came due to slow accrual.
Early Phase I Healthy trial by University of Missouri-Columbia. Stop reason: OTHER/UNKNOWN.
Interim data and power analysis
Early Phase I Breast Cancer trial by Milton S. Hershey Medical Center. Stop reason: OTHER/UNKNOWN.
Responsible Party left the institution and the study will not be started by other investigator
Early Phase I Squamous Cell Carcinoma of Head and Neck trial by M.D. Anderson Cancer Center. Stop reason: OTHER/UNKNOWN.
0 participants
Early Phase I Vestibular Schwannoma trial by Massachusetts Eye and Ear Infirmary. Stop reason: OPERATIONAL.
Drug manufacturing logistics; lack of access to drug supply
Early Phase I Obesity and Overweight trial by Helicore Biopharma, Inc.. Stop reason: OPERATIONAL.
Business decision
Early Phase I Conscious Sedation trial by Phoenix Children's Hospital. Stop reason: OTHER/UNKNOWN.
Never IRB reviewed or approved.
Early Phase I Nausea trial by Hackensack Meridian Health. Stop reason: OPERATIONAL.
Inability to recruit and staffing changes
Early Phase I Healthy trial by Johns Hopkins University. Stop reason: OTHER/UNKNOWN.
The investigators are revisiting in vitro and in vivo studies to ensure the ability to replicate the results of the original paper before proceeding to the pilot clinical study.
Early Phase I Healthy Volunteers trial by Johns Hopkins University. Stop reason: OTHER/UNKNOWN.
The lead investigator moved institutions and the study will not continue upon his departure.
Early Phase I Type1 Diabetes Mellitus trial by University of Maryland, Baltimore. Stop reason: OTHER/UNKNOWN.
We were unable to obtain GLP-1
Early Phase I Glioma trial by Nader Sanai. Stop reason: OTHER/UNKNOWN.
Study drug no longer available.
Early Phase I Ototoxicity, Drug-Induced trial by Children's Hospital Medical Center, Cincinnati. Stop reason: OTHER/UNKNOWN.
This study will be closing at CCHMC and may be transferred to a principal investigator at another insitutiton.
Early Phase I Glioblastoma Multiforme trial by Novartis Pharmaceuticals. Stop reason: OPERATIONAL.
Business reasons
Early Phase I REM Behavior Disorder trial by Brigham and Women's Hospital. Stop reason: OTHER/UNKNOWN.
Study will not longer be done. Terminated due to sponsor noncompliance.
Early Phase I Carpal Tunnel Syndrome trial by Columbia University. Stop reason: OPERATIONAL.
lack of funding
Early Phase I Metastatic Prostate Cancer trial by Blue Earth Therapeutics Ltd. Stop reason: EFFICACY/FUTILITY.
Based on data from the Interim Analysis, the study will not adequately inform the clinical development programme for Lutetium (177Lu) rhPSMA-10.1 injection in the way that the study was intended. There are no concerns regarding participant safety.
Early Phase I Graft-Versus-Host Disease(GVHD) trial by Baylor College of Medicine. Stop reason: OPERATIONAL.
There is no funding.
Early Phase I HPV 16+ Confirmed Oropharynx Cancer and Cervical Cancer trial by Hookipa Biotech GmbH. Stop reason: OPERATIONAL.
Sponsor decision.
Early Phase I ACHROMATOPSIA 7 trial by Columbia University. Stop reason: OPERATIONAL.
Administrative changes
Early Phase I Neurological Diseases trial by The Medical Pavilion Bahamas. Stop reason: OTHER/UNKNOWN.
Due to regulatory reasons
Early Phase I Ischemic Stroke trial by Yale University. Stop reason: OPERATIONAL.
seeking additional funding
Early Phase I Multiple Sclerosis trial by Biocells Medical. Stop reason: OPERATIONAL.
Slow enrolment of participants
Early Phase I Cannabis Use Disorder trial by Yale University. Stop reason: OPERATIONAL.
Insufficient funding
Early Phase I GBM trial by University of Texas Southwestern Medical Center. Stop reason: OPERATIONAL.
Administratively closed by the IRB.
Early Phase I Menstrual Symptoms trial by Maíta Poli de Araújo. Stop reason: OTHER/UNKNOWN.
The study was suspended due to non-compliance with the partnership agreement between the research team and the company that would supply Implanon. Therefore, it was not possible to continue the study
Early Phase I Hematopoietic and Lymphoid Cell Neoplasm trial by M.D. Anderson Cancer Center. Stop reason: OTHER/UNKNOWN.
\<75% participation
Early Phase I COVID-19 trial by Binhui Biopharmaceutical Co., Ltd.. Stop reason: OPERATIONAL.
Company strategy adjustment
Early Phase I Transgender Persons trial by The University of Texas Health Science Center at San Antonio. Stop reason: OTHER/UNKNOWN.
VA policy released 3/17/25 to phase out treatment for gender dysphoria
Early Phase I Triple Negative Breast Cancer trial by Virginia G. Kaklamani. Stop reason: OPERATIONAL.
Unable to enroll to study.
Early Phase I Squamous Cell Carcinoma of the Oral Cavity or Oropharynx trial by Mitchell Machtay. Stop reason: OPERATIONAL.
The study was not initiated due to funding constraints and will not proceed in its current design.
Early Phase I Relapsed/Refractory Autoimmune Diseases trial by Nanjing Legend Biotech Co.. Stop reason: OTHER/UNKNOWN.
Discontinue further development of LCAR-AIO program
Early Phase I IgA Nephropathy (IgAN) trial by Jieyang People's Hospital. Stop reason: OTHER/UNKNOWN.
Due to limitation of production capacity
Early Phase I COVID-19 Respiratory Infection trial by Medical University of Lublin. Stop reason: OTHER/UNKNOWN.
We are waiting for the additional founds.
Early Phase I Refractory Generalized Myasthenia Gravis trial by Zhejiang University. Stop reason: OTHER/UNKNOWN.
The study stopped early, before enrolling its first participant.
Early Phase I Pyoderma Gangrenosum trial by Dartmouth-Hitchcock Medical Center. Stop reason: OPERATIONAL.
Issues with funding and IND holder
Early Phase I Rib Fractures trial by George Washington University. Stop reason: OPERATIONAL.
not enough enrollment
Early Phase I Resectable Pancreatic Carcinoma trial by Jonsson Comprehensive Cancer Center. Stop reason: OPERATIONAL.
slow accrual
Early Phase I Relapsed or Refractory B Cell Acute Lymphoblastic Leukemia trial by Institute of Hematology & Blood Diseases Hospital, China. Stop reason: OTHER/UNKNOWN.
Due to adjustments in the company's strategy, the research and development of this project has been terminated.
Early Phase I Psoriasis trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
Terminated IRB approval 6/26/2024, study was never initiated or activated
Early Phase I Breast Cancer trial by Memorial Sloan Kettering Cancer Center. Stop reason: OPERATIONAL.
No accruals
Early Phase I Solid Tumors trial by Novartis Pharmaceuticals. Stop reason: OPERATIONAL.
Business reasons