Sponsor hub
Yale University clinical trial failures
Review 122 stopped clinical trials from Yale University, including disease areas, phases, and classified stop reasons.
This page groups real ClinicalTrials.gov-derived stopped trial records. The strongest added signal is the stop-reason classification: 4 of these records are likely biological failure signals, while the rest may reflect operational, strategic, regulatory, funding, enrollment, or unclear stop reasons.
Dominant stop reasons
- OPERATIONAL
- 76
- OTHER/UNKNOWN
- 40
- EFFICACY/FUTILITY
- 2
- REGULATORY
- 2
- SAFETY
- 2
Notable sponsors
- Yale University
- 122
Related phases
- Phase II
- 52
- Phase I
- 33
- Early Phase I
- 14
- Phase IV
- 12
- Unknown
- 8
Crawlable stopped-trial records
Open ExploreShowing up to 100 representative records from this slice. Each link opens the trial detail page with source attribution and stop-reason context.
Phase II Alcohol Drinking trial by Yale University. Stop reason: OPERATIONAL.
On hold until new funding acquired.
Phase II Melanoma trial by Yale University. Stop reason: EFFICACY/FUTILITY.
Lack of activity in the drugs
Phase I Post Traumatic Stress Disorder trial by Yale University. Stop reason: OPERATIONAL.
Funding ended.
Phase II Immune Checkpoint Inhibitor-Related Diarrhea and Colitis trial by Yale University. Stop reason: OTHER/UNKNOWN.
The study was terminated early as no patients were enrolled.
Phase IV Hidradenitis Suppurativa trial by Yale University. Stop reason: OTHER/UNKNOWN.
Study never officially began (or enrolled)
Phase II Acute Alcoholic Hepatitis trial by Yale University. Stop reason: OPERATIONAL.
Slow accrual
Early Phase I Ischemic Stroke trial by Yale University. Stop reason: OPERATIONAL.
seeking additional funding
Phase II Adolescent Suicide trial by Yale University. Stop reason: OPERATIONAL.
Terminated early due to concerns from the NIH DSMB regarding the rate of recruitment and the resulting inability to accomplish the initially approved study aims
Early Phase I Cannabis Use Disorder trial by Yale University. Stop reason: OPERATIONAL.
Insufficient funding
Phase II Head and Neck Squamous Cell Carcinoma trial by Yale University. Stop reason: OPERATIONAL.
Low enrollment
Phase I Tardive Dyskinesia trial by Yale University. Stop reason: OPERATIONAL.
Lack of funding.
Phase I Rib Fractures trial by Yale University. Stop reason: OPERATIONAL.
lack of enrollment
Phase I Muscarinic Receptor Occupancy trial by Yale University. Stop reason: OPERATIONAL.
lack of enrollment
Phase II Sarcoidosis trial by Yale University. Stop reason: OPERATIONAL.
Funding was rescinded.
Phase II COVID-19 Pneumonia trial by Yale University. Stop reason: OPERATIONAL.
Study terminated due to lack of enrollment reflecting the decrease in number of COVID infections. There were no safety and/or efficacy concerns involved in the decision to stop enrollment.
Phase IV Opioid Use trial by Yale University. Stop reason: OPERATIONAL.
Slow/low recruitment, unable to recruit
Phase II Urinary Tract Infections trial by Yale University. Stop reason: OPERATIONAL.
Funding issue
Phase II Hepatocellular Carcinoma trial by Yale University. Stop reason: OPERATIONAL.
Low enrollment
Phase IV Overweight and Obesity trial by Yale University. Stop reason: OTHER/UNKNOWN.
PI changed institutions
Phase IV Radiologically Isolated Syndrome trial by Yale University. Stop reason: OPERATIONAL.
Slow enrollment
Early Phase I Obesity, Childhood trial by Yale University. Stop reason: OPERATIONAL.
The study was initially paused due to COVID restrictions and then when able to resume, there was no longer funding.
Unknown Electronic Cigarette Use trial by Yale University. Stop reason: OPERATIONAL.
Recruitment halted by pandemic
Phase I Cancer Head Neck trial by Yale University. Stop reason: OTHER/UNKNOWN.
PI changed institutions
Phase I ADHD trial by Yale University. Stop reason: OPERATIONAL.
Following Yale University resuming in-person research activities, the investigators no longer had dedicated funding for the study and were unable to secure additional funding to meet the research goals.
Phase IV Diabetes trial by Yale University. Stop reason: OPERATIONAL.
COVID-19 led to changes in study design and an early end to data collection.
Early Phase I Polycystic Ovary Syndrome trial by Yale University. Stop reason: OPERATIONAL.
Unble to complete all arms of the planned study due to Covid stoppage and difficulty with recruiting and getting enrolled participants to return post Covid.
Phase II Acute Myeloid Leukemia trial by Yale University. Stop reason: OPERATIONAL.
Lack of funding.
Phase I Post-Traumatic Headache trial by Yale University. Stop reason: OPERATIONAL.
Challenging to recruit qualifying subjects
Early Phase I Cocaine Use Disorder trial by Yale University. Stop reason: OPERATIONAL.
Could not obtain additional funding to continue the research.
Phase II Pre-Eclampsia trial by Yale University. Stop reason: OPERATIONAL.
Unable to recruit.
Phase II Borderline Personality Disorder trial by Yale University. Stop reason: OPERATIONAL.
assessment of project in wake of covid-19 related interruptions
Phase I Obesity trial by Yale University. Stop reason: OTHER/UNKNOWN.
No longer able to run study
Phase II Major Depressive Disorder trial by Yale University. Stop reason: OPERATIONAL.
No more funding available to continue since we could not recruit throughout the pandemic.
Phase II Bipolar Depression trial by Yale University. Stop reason: OPERATIONAL.
No funding
Early Phase I Post Traumatic Stress Disorder trial by Yale University. Stop reason: OTHER/UNKNOWN.
Ligand was not effective.
Unknown Cocaine Dependence trial by Yale University. Stop reason: OTHER/UNKNOWN.
Study drug became unaffordable for the purposes of the research.
Phase I Hypertension trial by Yale University. Stop reason: OPERATIONAL.
not funded
Phase II Pancreatic Cancer trial by Yale University. Stop reason: OPERATIONAL.
Paused due to COVID. A determination was made to stop the study because it would be impossible to reach the 65% resection rate as outlined in the protocol.
Phase II Posttraumatic Stress Disorder trial by Yale University. Stop reason: OPERATIONAL.
Study ran out of funding
Phase II COVID-19 trial by Yale University. Stop reason: OPERATIONAL.
Study was terminated due to low enrollment.
Phase II Autism Spectrum Disorder trial by Yale University. Stop reason: OPERATIONAL.
Covid-19 Pandemic
Phase I Stage IVA Thymoma trial by Yale University. Stop reason: OTHER/UNKNOWN.
PI is not moving forward with study
Early Phase I Metastatic Melanoma trial by Yale University. Stop reason: OPERATIONAL.
lack of funds
Phase II PTLD trial by Yale University. Stop reason: OPERATIONAL.
Lack of funding
Early Phase I Cerebrospinal Fluid Pressure Increased trial by Yale University. Stop reason: OTHER/UNKNOWN.
The investigators were unable to implement a MRI compatible EEG for use in human subjects (equipment and technical issues).
Phase I Coagulopathy trial by Yale University. Stop reason: OPERATIONAL.
No funding
Phase IV Insomnia trial by Yale University. Stop reason: OPERATIONAL.
Study has been terminated due low recruitment of participant population.
Phase I Relapsed Lymphomas trial by Yale University. Stop reason: OPERATIONAL.
sponsor requested
Phase III Delirium trial by Yale University. Stop reason: OPERATIONAL.
Lack of resources to complete the study. Descriptive statistics for the outcome measures collected are provided.
Phase II Transitional Cell Carcinoma trial by Yale University. Stop reason: OPERATIONAL.
Funding was withdrawn prior to first enrollment.
Phase II Breast Cancer trial by Yale University. Stop reason: OPERATIONAL.
Phase 2 of recruitment was contingent on 5 of 15 patients responding, which did not occur.
Early Phase I Healthy trial by Yale University. Stop reason: OPERATIONAL.
Feasibility pilot was completed
Phase I Delta-9-Tetrahydroncannabinol trial by Yale University. Stop reason: OPERATIONAL.
Feasibility pilot was completed
Phase I MDS trial by Yale University. Stop reason: SAFETY.
Failure to enroll
Phase II Myelodysplastic Syndromes trial by Yale University. Stop reason: OTHER/UNKNOWN.
No patients were able to be screened nor enrolled.
Early Phase I Malignant Melanoma trial by Yale University. Stop reason: OPERATIONAL.
Funding
Phase II COVID-19 trial by Yale University. Stop reason: OPERATIONAL.
Study terminated due to lack of enrollment reflecting the decrease in number of COVID infections. There were no safety and/or efficacy concerns involved in the decision to stop enrollment.
Phase II ACUTE MYELOID LEUKEMIA trial by Yale University. Stop reason: OPERATIONAL.
Unable to accrue patients following COVID-19 study pause.
Phase II Cryptococcal Infection Disseminated trial by Yale University. Stop reason: OPERATIONAL.
Stopped in accordance with pre-specified stopping rules for poor recruitment.
Phase IV Tuberculosis trial by Yale University. Stop reason: OPERATIONAL.
COVID-19 Pandemic
Phase II Cholangitis, Sclerosing trial by Yale University. Stop reason: OPERATIONAL.
low recruitment
Phase IV Crohn's Disease trial by Yale University. Stop reason: OPERATIONAL.
insufficient enrollment
Phase III Prostate Cancer trial by Yale University. Stop reason: OPERATIONAL.
Unable to meet recruitment goals.
Early Phase I Clinical High Risk for Psychosis trial by Yale University. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Early Phase I End Stage Liver Disease trial by Yale University. Stop reason: OPERATIONAL.
Unable to recruit due to COVID 19
Phase II Hormone-Sensitive Breast Cancer trial by Yale University. Stop reason: OTHER/UNKNOWN.
Lack of recrual
Phase I Postpartum Hemorrhage trial by Yale University. Stop reason: OTHER/UNKNOWN.
The study never began.
Phase I Sickle Cell Disease trial by Yale University. Stop reason: OPERATIONAL.
Covid-19. Relocation of trainee/investigator. Covid-19.
Phase III Alcohol Dependence trial by Yale University. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Early Phase I Dental Caries trial by Yale University. Stop reason: OTHER/UNKNOWN.
Study was not conducted. No participants were enrolled
Phase II Deep Venous Thrombosis trial by Yale University. Stop reason: EFFICACY/FUTILITY.
Met protocol defined stopping rule for futility
Phase I Hepatic Encephalopathy trial by Yale University. Stop reason: OPERATIONAL.
No subjects were able to be recruited for the study.
Phase I Mental Disorders trial by Yale University. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase I Cocaine-Related Disorders trial by Yale University. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase II Borderline Personality Disorder trial by Yale University. Stop reason: OTHER/UNKNOWN.
Study terminated due to poor subject compliance.
Phase II Obsessive-Compulsive Disorder trial by Yale University. Stop reason: OPERATIONAL.
Researchers terminated study due to limited enrollment.
Unknown Bipolar Depression trial by Yale University. Stop reason: SAFETY.
Early indication of an unfavorable risk/benefit ratio.
Phase II Opiate Dependence trial by Yale University. Stop reason: OTHER/UNKNOWN.
Study was never able to start in IRAN
Phase II Pleural Effusion trial by Yale University. Stop reason: REGULATORY.
Local IRB recommended IND exemption from FDA, study timeline not able to be met.
Phase I Hodgkin's Lymphoma trial by Yale University. Stop reason: OTHER/UNKNOWN.
The study was terminated due to withdrawal of institutional support, Phase II never began.
Phase I Asymptomatic Myeloma trial by Yale University. Stop reason: REGULATORY.
Based on FDA requirements
Phase I Cocaine Dependent Subjects trial by Yale University. Stop reason: OPERATIONAL.
Not funded
Phase I Squamous Cell Carcinoma of the Head and Neck trial by Yale University. Stop reason: OPERATIONAL.
The study was stopped due to lack of funding.
Phase II Pancreas Adenocarcinoma trial by Yale University. Stop reason: OTHER/UNKNOWN.
Halozyme isn't allowing this trial to move forward until their current clinical trial results are released.
Phase II Unresectable Intrahepatic Cholangiocarcinoma trial by Yale University. Stop reason: OPERATIONAL.
Study terminated due to low enrollment making it unlikely to meet recruitment goals.
Phase II Lymphoma, T-Cell, Cutaneous trial by Yale University. Stop reason: OTHER/UNKNOWN.
Study sponsor sold and the new company would not support the study.
Unknown Papillary Thyroid Cancer trial by Yale University. Stop reason: OPERATIONAL.
Lack of patient enrollment
Phase II Schizophrenia trial by Yale University. Stop reason: OPERATIONAL.
Study discontinued due to funding.
Phase IV Hip Fractures trial by Yale University. Stop reason: OPERATIONAL.
Study was terminated due to inability to recruit and collect follow up outcome data.
Early Phase I Nicotine Dependence trial by Yale University. Stop reason: OPERATIONAL.
Lack of recruitment
Phase I Medication Absorption trial by Yale University. Stop reason: OTHER/UNKNOWN.
Study never officially began
Phase IV Pleural Effusion trial by Yale University. Stop reason: OTHER/UNKNOWN.
The site decided not to proceed with the protocol.
Phase I Tourette Syndrome trial by Yale University. Stop reason: OPERATIONAL.
no more funding available
Phase II Carcinoma, Non-small Cell Lung trial by Yale University. Stop reason: OTHER/UNKNOWN.
Trial was stopped after non-response to treatment.
Phase I Fallopian Tube Cancer trial by Yale University. Stop reason: OPERATIONAL.
No stop-reason text available in the compact dataset.
Phase IV Hyperoxia trial by Yale University. Stop reason: OTHER/UNKNOWN.
Study never officially began
Phase II Hepatocellular Carcinoma trial by Yale University. Stop reason: OTHER/UNKNOWN.
A future study will be taking place using the same patient population.
Phase I Relapsed and Refractory Aggressive B- and T-cell Lymphomas trial by Yale University. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase I Colorectal Cancer trial by Yale University. Stop reason: OTHER/UNKNOWN.
The study never officially funded and therefore never began.
Unknown Gastrointestinal Carcinoid Tumor trial by Yale University. Stop reason: OTHER/UNKNOWN.
High incidence of biloma and liver abscess after TACE