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Washington University School of Medicine clinical trial failures
Review 185 stopped clinical trials from Washington University School of Medicine, including disease areas, phases, and classified stop reasons.
This page groups real ClinicalTrials.gov-derived stopped trial records. The strongest added signal is the stop-reason classification: 14 of these records are likely biological failure signals, while the rest may reflect operational, strategic, regulatory, funding, enrollment, or unclear stop reasons.
Dominant stop reasons
- OPERATIONAL
- 94
- OTHER/UNKNOWN
- 77
- EFFICACY/FUTILITY
- 9
- SAFETY
- 5
Notable sponsors
- Washington University School of Medicine
- 185
Related phases
- Phase II
- 74
- Phase I
- 60
- Phase IV
- 20
- Unknown
- 19
- Early Phase I
- 10
Crawlable stopped-trial records
Open ExploreShowing up to 100 representative records from this slice. Each link opens the trial detail page with source attribution and stop-reason context.
Phase I Prostate Cancer trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
Low accrual
Phase II Anticholinergic Toxicity trial by Washington University School of Medicine. Stop reason: OTHER/UNKNOWN.
Physostigmine (standard of care treatment under this protocol) became unavailable at the study site June 1st 2026, requiring suspension of the study.
Phase II HER2-positive Breast Cancer trial by Washington University School of Medicine. Stop reason: EFFICACY/FUTILITY.
Futility
Phase II T-Cell Lymphoma trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
Loss of funding
Phase II Nasal Obstruction trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
low recruitment
Phase II Hearing Loss, Noise-Induced trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
Low accrual
Early Phase I Healthy trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
COVID pandemic No participant experiences (benefits, adverse events/adverse reactions)to report. There have been no safety concerns in either participant. No minor deviations to report
Unknown Irritable Bowel Syndrome trial by Washington University School of Medicine. Stop reason: OTHER/UNKNOWN.
Due to changes in trial personnel (co-investigator and research coordinator leaving the institution).
Phase II Headache, Migraine trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
The eligibility criteria within the protocol led to the exclusion of a large proportion of potential participants, thereby limiting enrollment. During the conceptualization phase, the number of eligible patients was overestimated.
Phase II Endometrial Hyperplasia trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
Low accrual
Phase IV Systemic Lidocaine Improves Pain Control After Surgery by Attenuating the Systemic Inflammatory Response to Surgery trial by Washington University School of Medicine. Stop reason: OTHER/UNKNOWN.
PI moved to a different institution.
Phase II Extensive-stage Small Cell Lung Cancer trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
Insufficient Funding/Staff
Phase II Postpartum Depression trial by Washington University School of Medicine. Stop reason: OTHER/UNKNOWN.
PI is leaving the university
Phase II Cancer Debulking trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
Low accrual
Phase II Pancreatic Cancer trial by Washington University School of Medicine. Stop reason: OTHER/UNKNOWN.
Investigator and study team chose to end study early.
Phase I Schizophrenia trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
Study recruitment milestones were not met.
Phase II Renal Cell Carcinoma trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
Slow enrollment with low accrual
Phase IV Obesity trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
The study was discontinued prematurely for administrative reasons
Phase II Cord Compression trial by Washington University School of Medicine. Stop reason: OTHER/UNKNOWN.
Pharmaceutical company decided to close study
Phase II Alzheimers Disease trial by Washington University School of Medicine. Stop reason: OTHER/UNKNOWN.
DIAN-TU announced the discontinuation of the DIAN-TU-001 OLE based on the status of the drug program and findings from an interim efficacy analysis and.
Phase IV Kidney Transplant trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
poor recruitment during pandemic and after
Phase II Hearing Loss, Noise-Induced trial by Washington University School of Medicine. Stop reason: OTHER/UNKNOWN.
PINIHL Program terminated by DoD
Phase II Gastric Adenocarcinoma trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
Poor accrual and funding sponsor declared bankruptcy.
Phase II Cancer trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
Low accrual
Phase II Relapsed Acute Myeloid Leukemia trial by Washington University School of Medicine. Stop reason: OTHER/UNKNOWN.
The sponsor is no longer supporting the drug
Phase I Small-cell Lung Cancer trial by Washington University School of Medicine. Stop reason: EFFICACY/FUTILITY.
Futility
Phase I Head and Neck Cancer trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
Insufficient funding/staff
Early Phase I Multiple Myeloma trial by Washington University School of Medicine. Stop reason: OTHER/UNKNOWN.
Drug formulation changed, opening new trial
Phase II Obesity trial by Washington University School of Medicine. Stop reason: OTHER/UNKNOWN.
Unable to obtain study drug to be able to perform the study
Phase II Glioma trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
Low accruals and competing clinical trials
Unknown Forearm Injuries trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
Project canceled for other reason , describe: - Lack of enrollment Project canceled - lack of enrollment
Phase II Pancreatic Cancer trial by Washington University School of Medicine. Stop reason: OTHER/UNKNOWN.
Celldex decision
Phase I Recurrent High Grade Uterine Cancer trial by Washington University School of Medicine. Stop reason: OTHER/UNKNOWN.
Trial did not go forward
Phase II Major Depressive Disorder trial by Washington University School of Medicine. Stop reason: OTHER/UNKNOWN.
Resident who was tasked with coordinating this study is no longer able to do so.
Phase I Pancreas Cancer trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
Insufficient funding/staff
Phase II Multiple Myeloma trial by Washington University School of Medicine. Stop reason: OTHER/UNKNOWN.
Study sponsor decided to close study.
Early Phase I Diffuse Large B Cell Lymphoma trial by Washington University School of Medicine. Stop reason: EFFICACY/FUTILITY.
Futility
Phase I Triple Negative Breast Cancer trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
Drugs/equipment unavailable and insufficient funding
Phase III Coronavirus Infection trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
DSMB recommended study suspension slow accrual
Phase II Angioedema Caused by Angiotensin-Converting-Enzyme Inhibitor trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
End of funding period
Phase I Multiple Myeloma trial by Washington University School of Medicine. Stop reason: OTHER/UNKNOWN.
Decision made to not move forward with Phase II portion of trial
Phase I Head and Neck Squamous Cell Carcinoma trial by Washington University School of Medicine. Stop reason: OTHER/UNKNOWN.
Ipsen bought out Epizyme
Phase II Stage II Melanoma trial by Washington University School of Medicine. Stop reason: OTHER/UNKNOWN.
Sponsor made decision to terminate study.
Phase I Multiple Myeloma trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
Low accrual
Phase I Leukemia, Myeloid, Acute trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
Insufficient funding/staff
Unknown Type 2 Diabetes Mellitus trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
COVID-19 \& loss of funding
Phase I Central Nervous System Neoplasms trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
Insufficient funding/staff
Phase IV Radius Fracture Distal trial by Washington University School of Medicine. Stop reason: OTHER/UNKNOWN.
Sponsoring staff have left institution
Phase II Myelofibrosis trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
Low accrual
Phase I Advanced Solid Tumor trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
Sponsor decision
Phase II Mucous Membrane Pemphigoid trial by Washington University School of Medicine. Stop reason: OTHER/UNKNOWN.
Sponsor
Phase II T-Acute Lymphoblastic Leukemia trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
Low accrual
Phase I Pancreatic Cancer trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
Loss of funding
Phase I Follicular Lymphoma trial by Washington University School of Medicine. Stop reason: OTHER/UNKNOWN.
Vaccine manufacturing has been suspended
Phase II Ocular Graft-versus-host Disease trial by Washington University School of Medicine. Stop reason: OTHER/UNKNOWN.
Investigator decided to close study
Phase II Triple Negative Breast Cancer trial by Washington University School of Medicine. Stop reason: OTHER/UNKNOWN.
No drug
Phase I Meningioma trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
Study sponsor wanted to terminate enrollment.
Phase I Olfactory Disorder trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
Study halted prematurely; IRB approval not obtained
Phase I Acute Graft Versus Host Disease trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
Lost funding
Phase I Anxiety Disorders trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
COVID and staffing issues
Phase II Refractory Acute Myeloid Leukemia trial by Washington University School of Medicine. Stop reason: OTHER/UNKNOWN.
Principal investigator decided not to move forward with the study.
Phase II Major Depressive Disorder trial by Washington University School of Medicine. Stop reason: OTHER/UNKNOWN.
Due to negative results in similar trials using 11C-UCB-J
Unknown Pediatric Brain Tumor trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
Low accrual
Phase IV Skin Infection trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
Funding and recruitment limited by pandemic
Phase II Triple Negative Breast Neoplasms trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
Insufficient funding/staff
Phase II Breast Neoplasms trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
Loss of study funding
Phase I Type 1 Diabetes trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
Loss of funding
Early Phase I Coronary Artery Disease trial by Washington University School of Medicine. Stop reason: OTHER/UNKNOWN.
re-evaluation of radiotracer
Phase I Cholangiocarcinoma trial by Washington University School of Medicine. Stop reason: OTHER/UNKNOWN.
Equipment that was used in the study was discontinued
Phase IV UTI trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
Project canceled due to PI leaving institution, staff changes and COVID Project canceled for other reason , describe: - Due to staff changes and COVID Project canceled due to PI leaving, staff changes and COVID
Phase II Melanoma With Brain Metastasis trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
The study was terminated early on 03/09/2022 due to low accrual during the COVID-19 pandemic.
Phase II Acute Myeloid Leukemia trial by Washington University School of Medicine. Stop reason: EFFICACY/FUTILITY.
Futility
Phase I Neuropathic Pain trial by Washington University School of Medicine. Stop reason: SAFETY.
Adverse effects related to study procedure (not study drug)
Phase I Gastrointestinal Neoplasms trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
Low accrual
Phase II Relapsed Acute Myeloid Leukemia trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
No funding support
Phase II COVID-19 trial by Washington University School of Medicine. Stop reason: OTHER/UNKNOWN.
Unable to obtain investigational product
Phase I Triple Negative Breast Cancer trial by Washington University School of Medicine. Stop reason: OTHER/UNKNOWN.
Drugs not available
Phase I Sickle Cell Disease trial by Washington University School of Medicine. Stop reason: OTHER/UNKNOWN.
Closed early due to competing studies
Phase II Urinary Tract Infections trial by Washington University School of Medicine. Stop reason: EFFICACY/FUTILITY.
Performed a futility analysis and determined that study objectives could not be met.
Phase II Multiple Myeloma trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
Investigator decision
Phase I Myelofibroses trial by Washington University School of Medicine. Stop reason: OTHER/UNKNOWN.
Sponsor stopped development of pevonedistat
Phase II HER2-positive Solid Tumor trial by Washington University School of Medicine. Stop reason: OTHER/UNKNOWN.
Insufficient staff
Phase I Pancreatic Cancer trial by Washington University School of Medicine. Stop reason: OTHER/UNKNOWN.
One of the investigators is leaving the University.
Phase II Non-small Cell Lung Cancer trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
Lost funding
Phase I Glioblastoma trial by Washington University School of Medicine. Stop reason: OTHER/UNKNOWN.
Manufacturer changed focus to cell therapy
Unknown Breast Cancer trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
Study Funding no longer available
Phase II Alpha-1-antitrypsin Deficiency trial by Washington University School of Medicine. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase II Breast Cancer trial by Washington University School of Medicine. Stop reason: EFFICACY/FUTILITY.
Futility
Phase I Epithelial Ovarian Cancer trial by Washington University School of Medicine. Stop reason: OTHER/UNKNOWN.
Trial may move forward as an NCI-sponsored trial and not an investigator initiated trial.
Phase I COVID-19 trial by Washington University School of Medicine. Stop reason: OTHER/UNKNOWN.
Principal investigator is leaving the institution.
Phase IV Abdominal Aortic Aneurysm (AAA) trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
We were unable to recruit more subjects who met the inclusion/exclusion criteria and we have closed the study.
Phase I Adenocarcinoma trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
Pharmaceutical company decision
Phase I Metastatic Breast Cancer trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
Sponsor decision.
Phase I Pediatric Brain Tumor trial by Washington University School of Medicine. Stop reason: OTHER/UNKNOWN.
Made the decision to not go forward with the study
Phase I Pancreatic Cancer trial by Washington University School of Medicine. Stop reason: SAFETY.
Adverse events
Phase II Anosmia trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
Funding not received
Unknown Cervical Myelopathy trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
Sponsor closed study due to low enrollment Sponsor closed study due to low enrollment Sponsor closed study due to low enrollment.
Phase II Migraine in Children trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
Low enrollment
Phase IV Renal Injury trial by Washington University School of Medicine. Stop reason: OPERATIONAL.
Funding ended
Phase I Head and Neck Squamous Cell Carcinoma trial by Washington University School of Medicine. Stop reason: OTHER/UNKNOWN.
Provider of drug decided to discontinue study.