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Wake Forest University Health Sciences clinical trial failures
Review 130 stopped clinical trials from Wake Forest University Health Sciences, including disease areas, phases, and classified stop reasons.
This page groups real ClinicalTrials.gov-derived stopped trial records. The strongest added signal is the stop-reason classification: 6 of these records are likely biological failure signals, while the rest may reflect operational, strategic, regulatory, funding, enrollment, or unclear stop reasons.
Dominant stop reasons
- OPERATIONAL
- 88
- OTHER/UNKNOWN
- 36
- SAFETY
- 4
- EFFICACY/FUTILITY
- 2
Notable sponsors
- Wake Forest University Health Sciences
- 130
Related phases
- Phase II
- 59
- Phase IV
- 23
- Phase I
- 19
- Early Phase I
- 14
- Unknown
- 10
Crawlable stopped-trial records
Open ExploreShowing up to 100 representative records from this slice. Each link opens the trial detail page with source attribution and stop-reason context.
Early Phase I Epidural Spinal Tumors trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
Low accruals
Phase II Pain Management trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
Study initially suspended following an audit and need of amendment to address deficiencies. PI requested to terminate due to lack of support.
Early Phase I Anatomic Stage IV Breast Cancer AJCC v8 trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
Low accruals
Phase II Hepatocellular Carcinoma trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
Slow accruals
Phase I Multiple Sclerosis, Progressive trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
lack of funding
Phase I Soft Tissue Sarcoma trial by Wake Forest University Health Sciences. Stop reason: SAFETY.
Terminated due DLTs
Phase I Protoporphyria trial by Wake Forest University Health Sciences. Stop reason: OTHER/UNKNOWN.
department leadership decided not to proceed with study
Phase II Glioma trial by Wake Forest University Health Sciences. Stop reason: OTHER/UNKNOWN.
Axsome has conducted a review of the ongoing IST program and are unable to continue supporting this study
Phase II Osteoarthritis, Knee trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
Data from the initial participants were analyzed to support an NIH grant submission, leading to NIH funding of a new protocol to expand on the initial results.
Phase II Hidradenitis Suppurativa trial by Wake Forest University Health Sciences. Stop reason: OTHER/UNKNOWN.
Drug company did not approve use of the drug, IRB never approved
Phase IV Pain trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
lack of continued funding support
Phase II Osteoarthritis, Knee trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
Study was not initiated; no subjects enrolled. A replacement study will be submitted
Phase II Mild Cognitive Impairment trial by Wake Forest University Health Sciences. Stop reason: OTHER/UNKNOWN.
protocol being rewritten and submitted as new study
Phase II Cystic Fibrosis trial by Wake Forest University Health Sciences. Stop reason: OTHER/UNKNOWN.
new drug formulation by the manufacturer
Early Phase I Psoriasis trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
Terminated IRB approval 6/26/2024, study was never initiated or activated
Phase II Relapsed T-Cell Lymphoma trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
Low accruals
Phase IV Alzheimer Disease trial by Wake Forest University Health Sciences. Stop reason: OTHER/UNKNOWN.
withdrawn by the PI
Phase II Non Small Cell Lung Cancer trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
No enrollments, low patient population as well as a dramatic change in the insurance approval processes for oligoprogressive state with eviCore saying they do not support SBRT in this setting at all.
Early Phase I Human Papillomavirus Infection trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
Study closed prior to meeting enrollment goal and funding issues
Phase IV Retinal Vein Occlusion trial by Wake Forest University Health Sciences. Stop reason: SAFETY.
IRB stopped study due to safety concerns. No further data collection and what has been collected is not appropriate for analysis.
Phase II Prostate Carcinoma trial by Wake Forest University Health Sciences. Stop reason: OTHER/UNKNOWN.
PIs not interested in continuing with the trial.
Phase II Pain, Chronic trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
Study was never initiated and has been withdrawn and replaced with a new protocol.
Phase II Previously Treated Myelodysplastic Syndromes trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
Drug sponsor suspended study prematurely then study was terminated. Expected enrollment was not met.
Phase I Acute Respiratory Distress Syndrome trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
drug has expired, no enrollments in study. Company pulled funding
Unknown Colorectal Cancer trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
no patients enrolled
Phase II Diabetic Gastroparesis trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
low enrollment
Phase II Melanoma (Skin) trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
administrative decision- PI retired and treating physician left the institution
Phase II Glioblastoma trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
Investigator decision
Phase II Acute Myeloid Leukemia, in Relapse trial by Wake Forest University Health Sciences. Stop reason: OTHER/UNKNOWN.
PI decided not to move forward with the study
Phase II Osteoarthritis, Knee trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
Study was not initiated. No subjects enrolled.
Phase IV Febrile Neutropenia trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
Study was never initiated or activated - Reason was lack of funding
Phase II Injection Site Irritation trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
feasibility of enrollment
Phase IV Carbapenem-Resistant Enterobacteriaceae Infection trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
Lack of enrollment
Phase IV Carbon Dioxide Laser trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
Study halted prematurely and will not resume; participants are no longer being examined or receiving intervention. PI decided to terminate due to slow enrollment.
Phase II Solid Tumor trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
PI left the institution and site decided not to continue the study
Phase II EGFR Activating Mutation trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
Slow accrual, closed by IRB
Phase II Colorectal Cancer trial by Wake Forest University Health Sciences. Stop reason: OTHER/UNKNOWN.
Funder terminated.
Phase IV Postoperative Pain trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
Lack of resources to continue.
Phase IV Exudative Age Related Macular Degeneration trial by Wake Forest University Health Sciences. Stop reason: SAFETY.
IRB stopped study due to safety concerns before any participants were enrolled.
Phase IV Infection trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
The study was closed due to slow enrollment.
Phase IV Urinary Retention trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
Challenges in enrollment led to decission for termination
Early Phase I Non Small Cell Lung Cancer trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
Slow accruals
Phase IV Snake Envenomation trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
Study terminated due to declining enrollment; data analysis proceeding.
Phase IV Shoulder Arthroplasty trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
feasibility
Phase IV Anticoagulants and Bleeding Disorders trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
enrollment proved to be a challenge due to the changing of the guidelines for bridging off the new anticoagulants that are being prescribed
Phase II Neuropathic Pain trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
Cessation of funding period prior to completion, due to slow recruitment during the pandemic
Phase II Healthy Volunteer Study trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
Cessation of funding period prior to completion, due to slow recruitment during the pandemic
Early Phase I Central Centrifugal Cicatricial Alopecia trial by Wake Forest University Health Sciences. Stop reason: OTHER/UNKNOWN.
The IRB was closed without enrolling any participants
Phase II Small Cell Lung Carcinoma trial by Wake Forest University Health Sciences. Stop reason: EFFICACY/FUTILITY.
After interim analysis decided not to move forward with continuing the trial.
Phase III Endometrial Hyperplasia trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
PI decision
Phase IV Gram-Positive Bacterial Infections trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
Lack of funding
Early Phase I Current Smoker trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
Slow accrual
Early Phase I Soft Tissue Sarcoma trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
Enrollment of eligible subjects, delays due to the COVID-19 Virus, and lack of funding
Phase II Osteoarthritis, Knee trial by Wake Forest University Health Sciences. Stop reason: OTHER/UNKNOWN.
Study will be replaced by a revised study protocol
Phase II Head and Neck Cancer trial by Wake Forest University Health Sciences. Stop reason: OTHER/UNKNOWN.
Concept is withdrawn and a different concept will be submitted the near future.
Phase II Postoperative Pain trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
Cessation of funding period prior to completion, due to slow recruitment during the pandemic.
Phase II Urinary Bladder Neoplasms trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
Study closed to accrual due to low accrual numbers.
Phase II Cancer of Brain and Nervous System trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
closed to accrual due to low accrual
Phase III Pulmonary Embolism trial by Wake Forest University Health Sciences. Stop reason: OTHER/UNKNOWN.
PI changed institution and impossible to solve problem with contract's sites
Phase IV Menopause Related Conditions trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
Per PI: "Never went to IRB Never recruited anyone Never resubmitted the score NIH application I am leaving the institution"
Phase II Nonsmall Cell Lung Cancer, Stage II trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
Low accruals
Phase IV Hidradenitis Suppurativa trial by Wake Forest University Health Sciences. Stop reason: OTHER/UNKNOWN.
Sponsor and site agreed the research would not happen now; several delays and other issues
Phase II Radical Prostatectomies trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
PI left institution and study was not transferred to new PI
Phase II Appendix Cancer trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
Low enrollment
Phase IV Diabetic Maculopathy trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
lack of funding
Phase II Benign Headache trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
Unable to enroll adequate number of patients.
Phase II Opioid Use trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
Funding for uninsured subjects could not be realized and staffing after COVID hit was also a problem.
Phase II Recurrent Pregnancy Loss Without Current Pregnancy trial by Wake Forest University Health Sciences. Stop reason: OTHER/UNKNOWN.
Investigator still working on protocol and not sure when it will be ready
Unknown Traumatic Brain Injury trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
Principal investigator took a position at another institution. No subjects enrolled.
Phase II Pancreatic Neoplasms trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
no accrual rate
Phase II Multiple Myeloma trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
Low enrollment due to competing studies
Phase I Breast Cancer trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
Funding was terminated.
Phase I Septic Shock trial by Wake Forest University Health Sciences. Stop reason: OTHER/UNKNOWN.
Study stopped to open expanded phase II study
Phase I Immunodeficiency trial by Wake Forest University Health Sciences. Stop reason: OTHER/UNKNOWN.
Sponsor/ PI leaving institution, no plans to continue this research at this time
Phase II Multiple Myeloma trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
Difficult enrollment due to changes in standard of care
Unknown Equinus Contracture trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
Low accrual rate
Unknown Obesity trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
Low enrollment
Phase III Acute Myeloid Leukemia (AML) trial by Wake Forest University Health Sciences. Stop reason: OTHER/UNKNOWN.
Study terminated 7/23/2019 due to limited participation and testing challenges.
Phase II Endometriosis trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
Lack of funding
Phase II Breast Cancer trial by Wake Forest University Health Sciences. Stop reason: OTHER/UNKNOWN.
Stopped due to concerns about interaction between St. John's wort and Tamoxifen.
Phase III Hot Flashes trial by Wake Forest University Health Sciences. Stop reason: SAFETY.
Stopped by the DSMB for lack of effect per interim stopping rule.
Phase III Brain and Central Nervous System Tumors trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
low accrual; loss of funding
Phase IV COPD trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
Lower enrollment than Sponsor expected - Sponsor stopped study
Phase II Osteoarthritis, Knee trial by Wake Forest University Health Sciences. Stop reason: OTHER/UNKNOWN.
study team decided not to proceed with project
Phase II Pyoderma Gangrenosum trial by Wake Forest University Health Sciences. Stop reason: OTHER/UNKNOWN.
Contracting never completed, closed the IRB
Phase I Urologic Injuries trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
Lack of Funding
Phase I Myelodysplastic Syndromes trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
Administrative withdrawal by IRB
Phase II Osteoarthritis, Knee trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
Study was not initiated; no subjects were consented or enrolled
Early Phase I Psoriasis trial by Wake Forest University Health Sciences. Stop reason: OTHER/UNKNOWN.
FDA did not provide approval of the use of the drug for the study
Early Phase I Frailty Syndrome trial by Wake Forest University Health Sciences. Stop reason: OTHER/UNKNOWN.
Protocol required revisions and application was withdrawn from the IRB.
Phase II Perfusion trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
PI decision due to slow accrual
Phase II Pyoderma Gangrenosum trial by Wake Forest University Health Sciences. Stop reason: OTHER/UNKNOWN.
Dr. Jorizzo has withdrawn from this study due to time it is taking to start
Phase IV Anxiety trial by Wake Forest University Health Sciences. Stop reason: OTHER/UNKNOWN.
Decided not to perform the pilot phase
Phase II Recurrent Adult Acute Myeloid Leukemia trial by Wake Forest University Health Sciences. Stop reason: EFFICACY/FUTILITY.
The study was stopped early due to futility.
Phase I Head and Neck Cancer trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
Drug Supply Issue
Phase I Pancreatic Cancer trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
slow accrual
Early Phase I Pain, Postoperative trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
Lack of Funding
Phase IV Peripheral Arterial Disease trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
Original PI left institution
Early Phase I Coronary Artery Disease trial by Wake Forest University Health Sciences. Stop reason: OTHER/UNKNOWN.
Potential participants with COPD/asthma unwilling to participate.
Phase IV Pain trial by Wake Forest University Health Sciences. Stop reason: OPERATIONAL.
funding and compounding issues