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Virginia Commonwealth University clinical trial failures
Review 54 stopped clinical trials from Virginia Commonwealth University, including disease areas, phases, and classified stop reasons.
This page groups real ClinicalTrials.gov-derived stopped trial records. The strongest added signal is the stop-reason classification: 1 of these records are likely biological failure signals, while the rest may reflect operational, strategic, regulatory, funding, enrollment, or unclear stop reasons.
Dominant stop reasons
- OPERATIONAL
- 30
- OTHER/UNKNOWN
- 22
- EFFICACY/FUTILITY
- 1
- REGULATORY
- 1
Notable sponsors
- Virginia Commonwealth University
- 54
Related phases
- Phase II
- 15
- Phase I
- 14
- Phase IV
- 12
- Phase III
- 7
- Early Phase I
- 3
Crawlable stopped-trial records
Open ExploreShowing up to 54 representative records from this slice. Each link opens the trial detail page with source attribution and stop-reason context.
Phase I Solid Tumor, Adult trial by Virginia Commonwealth University. Stop reason: OTHER/UNKNOWN.
Pending amendment approval
Phase I Periorbital Burns trial by Virginia Commonwealth University. Stop reason: OTHER/UNKNOWN.
Inventory not available
Phase II Neuropathic Pain trial by Virginia Commonwealth University. Stop reason: OPERATIONAL.
Insufficient staffing
Phase II Endometrial Cancer trial by Virginia Commonwealth University. Stop reason: OPERATIONAL.
Closed early due to low enrollment rates
Early Phase I Chronic Obstructive Pulmonary Disease trial by Virginia Commonwealth University. Stop reason: OPERATIONAL.
Funding was inconsistent and the Post-Doc left before the project ended
Early Phase I Schizophrenia trial by Virginia Commonwealth University. Stop reason: OPERATIONAL.
PIs were unable to recruit any participants
Phase II Caries,Dental trial by Virginia Commonwealth University. Stop reason: OTHER/UNKNOWN.
Manufacture of drug discontinued before any participants could be enrolled.
Phase II Cardiac Surgery trial by Virginia Commonwealth University. Stop reason: OTHER/UNKNOWN.
Loss of funds
Phase II Neuropathy trial by Virginia Commonwealth University. Stop reason: OPERATIONAL.
Low Accrual Rate
Phase III Breast Cancer - Female trial by Virginia Commonwealth University. Stop reason: EFFICACY/FUTILITY.
Lack of efficacy
Phase III Sepsis trial by Virginia Commonwealth University. Stop reason: OTHER/UNKNOWN.
Recent studies suggest an increase in mortality due to high-does Vitamin C
Phase IV Vaginal Bleeding trial by Virginia Commonwealth University. Stop reason: OPERATIONAL.
Anticipated funding was not received
Phase III Periodontitis Chronic Generalized Severe trial by Virginia Commonwealth University. Stop reason: OTHER/UNKNOWN.
Fellow graduated before successfully enrolling any participants
Phase III Opioid Use Disorder trial by Virginia Commonwealth University. Stop reason: OPERATIONAL.
Due to a financial business decision by the company supporting the research study (Indivior). The decision was not due to adverse events, safety reasons, or scientific reasons, but was a business decision.
Phase III Immunologic Desensitization trial by Virginia Commonwealth University. Stop reason: OTHER/UNKNOWN.
Intellectual property issues with drug manufacture.
Phase IV Osteoarthritis, Knee trial by Virginia Commonwealth University. Stop reason: OTHER/UNKNOWN.
Study's primary aims are no longer clinically impactful, as intrathecal morphine has fallen out of favor and replaced with different agents so that outpatient/23 hr surgery is more predictably achievable.
Phase I Chronic Lymphocytic Leukemia trial by Virginia Commonwealth University. Stop reason: OPERATIONAL.
Slow Accrual
Phase II Hyperuricemia trial by Virginia Commonwealth University. Stop reason: OPERATIONAL.
inability to achieve recruitment goals at a single center and given the current pandemic conditions
Phase IV Burns trial by Virginia Commonwealth University. Stop reason: OPERATIONAL.
PI is working on getting funding for the study and wishes to withdraw the study until that funding is secured.
Phase I Relapsed Small Cell Lung Cancer trial by Virginia Commonwealth University. Stop reason: OTHER/UNKNOWN.
AbbVie decided to stop trial involving Venetoclax for safety measures needed
Phase II Acute Pericarditis trial by Virginia Commonwealth University. Stop reason: OPERATIONAL.
Study was terminated because dramatic benefits seen during the first 24 hours of drug administration combined with COVID restrictions on research activities suggested it was both unethical and unnecessary to complete the planned enrollment
Phase III Opioid Use Disorder trial by Virginia Commonwealth University. Stop reason: OTHER/UNKNOWN.
Funder has not approved protocol
Phase II Cystic Fibrosis trial by Virginia Commonwealth University. Stop reason: OPERATIONAL.
terminated due to an inability to recruit study subjects
Phase II Caries,Dental trial by Virginia Commonwealth University. Stop reason: OTHER/UNKNOWN.
Drug is no longer being manufactured
Phase I Rib Fractures trial by Virginia Commonwealth University. Stop reason: OPERATIONAL.
Insufficient enrollment
Phase II Breast Cancer trial by Virginia Commonwealth University. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase II Caries,Dental trial by Virginia Commonwealth University. Stop reason: OTHER/UNKNOWN.
Manufacturer discontinued drug before any participants could be enrolled.
Phase I Cocaine-Related Disorders trial by Virginia Commonwealth University. Stop reason: REGULATORY.
FDA removal of drug from the market due to cancer risks
Phase IV Pain, Postoperative trial by Virginia Commonwealth University. Stop reason: OTHER/UNKNOWN.
Change in hospital protocol
Phase I Renal Cell Carcinoma trial by Virginia Commonwealth University. Stop reason: OTHER/UNKNOWN.
Study drug no longer being clinically developed by manufacturer
Phase IV Pain, Postoperative trial by Virginia Commonwealth University. Stop reason: OPERATIONAL.
Did not receive funding
Phase I Disorder of Vitamin C trial by Virginia Commonwealth University. Stop reason: OTHER/UNKNOWN.
Therapy shown effective by larger studies
Phase II Heart Failure, Systolic trial by Virginia Commonwealth University. Stop reason: OPERATIONAL.
We screened over 200 patients but were ultimately unable to enroll anyone
Phase IV Pruritus trial by Virginia Commonwealth University. Stop reason: OPERATIONAL.
Unable to recruit patients
Phase IV Heart Diseases trial by Virginia Commonwealth University. Stop reason: OTHER/UNKNOWN.
Unable to find participants who met inclusion/exclusion criteria
Phase I Cesarean Section trial by Virginia Commonwealth University. Stop reason: OTHER/UNKNOWN.
Lack of reliable supply of of preservative free IV Hydromorphone for intrathecal use.
Phase I Congenital Cytomegalovirus Infection trial by Virginia Commonwealth University. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase I Pulmonary Hypertension trial by Virginia Commonwealth University. Stop reason: OPERATIONAL.
recruitment issues, critical investigators left institution
Phase III Patellofemoral Pain Syndrome trial by Virginia Commonwealth University. Stop reason: OPERATIONAL.
Insufficient recruitment in a reasonable time + expiration of study medication
Phase IV PCOS trial by Virginia Commonwealth University. Stop reason: OTHER/UNKNOWN.
P.I. left University. Study terminated
Phase IV Resistant Hypertension in Kidney Transplant Patients trial by Virginia Commonwealth University. Stop reason: OTHER/UNKNOWN.
The patient population changed. Unable to find patients that meet study criteria
Phase I Salivary Gland Squamous Cell Carcinoma trial by Virginia Commonwealth University. Stop reason: OPERATIONAL.
The study was terminated. The data analysis was futile with only 3 accruals. PI opted to terminate with IRB and withdraw FDA IND.
Unknown Contraception Desired trial by Virginia Commonwealth University. Stop reason: OPERATIONAL.
difficulty in subject recruitment
Unknown Polycystic Ovary Syndrome trial by Virginia Commonwealth University. Stop reason: OPERATIONAL.
Lack of recruitment
Phase II Cytomegalovirus Infections trial by Virginia Commonwealth University. Stop reason: OPERATIONAL.
Suspended due to lack of funding
Phase IV Alcohol Dependence trial by Virginia Commonwealth University. Stop reason: OPERATIONAL.
Not enough sugjects enrolled before funding ran out
Phase IV Alcoholism trial by Virginia Commonwealth University. Stop reason: OPERATIONAL.
Due to logistical purposes
Phase II Shock, Hemorrhagic trial by Virginia Commonwealth University. Stop reason: OPERATIONAL.
Low patient enrollment is the primary reason
Phase IV Congestive Heart Failure trial by Virginia Commonwealth University. Stop reason: OPERATIONAL.
Futility for enrollment
Unknown Gastroesophageal Reflux Disease trial by Virginia Commonwealth University. Stop reason: OPERATIONAL.
Could not recruit patients - modifying protocol and plan resubmission to our IRB
Phase II Metabolic Syndrome trial by Virginia Commonwealth University. Stop reason: OPERATIONAL.
Budgetary Issues
Early Phase I Epithelial Cancer trial by Virginia Commonwealth University. Stop reason: OPERATIONAL.
Slow accrual
Phase I Adenocarcinoma of the Lung trial by Virginia Commonwealth University. Stop reason: OPERATIONAL.
Due to no accrual.
Phase I Bone Metastases trial by Virginia Commonwealth University. Stop reason: OTHER/UNKNOWN.
Recently published data that has shown HCQ to be safe when combined with chemo and or radiation at even higher doses than what is used in this study.