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VA Office of Research and Development clinical trial failures
Review 46 stopped clinical trials from VA Office of Research and Development, including disease areas, phases, and classified stop reasons.
This page groups real ClinicalTrials.gov-derived stopped trial records. The strongest added signal is the stop-reason classification: 3 of these records are likely biological failure signals, while the rest may reflect operational, strategic, regulatory, funding, enrollment, or unclear stop reasons.
Dominant stop reasons
- OPERATIONAL
- 32
- OTHER/UNKNOWN
- 10
- SAFETY
- 2
- EFFICACY/FUTILITY
- 1
- REGULATORY
- 1
Notable sponsors
- VA Office of Research and Development
- 46
Related phases
- Phase II
- 16
- Phase IV
- 13
- Phase I
- 9
- Phase III
- 3
- Unknown
- 3
Crawlable stopped-trial records
Open ExploreShowing up to 46 representative records from this slice. Each link opens the trial detail page with source attribution and stop-reason context.
Phase IV Posttraumatic Stress Disorder trial by VA Office of Research and Development. Stop reason: OPERATIONAL.
difficulty meeting recruitment goals
Early Phase I SCI trial by VA Office of Research and Development. Stop reason: OPERATIONAL.
the study no longer has funding
Phase II Early Stage Lung Cancer (I and II) trial by VA Office of Research and Development. Stop reason: OPERATIONAL.
Early termination by sponsor due to substantial delays with subjects recruitment
Phase II Schizophrenia trial by VA Office of Research and Development. Stop reason: OPERATIONAL.
Inadequate Subject Recruitment
Phase II Chronic Kidney Disease trial by VA Office of Research and Development. Stop reason: OTHER/UNKNOWN.
The trial was stopped because of inability to reach target sample size.
Phase IV Clostridium trial by VA Office of Research and Development. Stop reason: OPERATIONAL.
The study sponsor stopped the trial early after enrolling 308 of the target sample size because of a slower than expected recruitment rate.
Phase I Advanced Urothelial Carcinoma trial by VA Office of Research and Development. Stop reason: OTHER/UNKNOWN.
The study drug is not available.
Phase IV Insulin Secretion trial by VA Office of Research and Development. Stop reason: OPERATIONAL.
Funding expired
Phase IV Obesity trial by VA Office of Research and Development. Stop reason: OPERATIONAL.
Study drug no longer available
Phase I Stage IV NSCLC trial by VA Office of Research and Development. Stop reason: OPERATIONAL.
The funding for this trial was removed.
Phase II Tobacco Use Disorder trial by VA Office of Research and Development. Stop reason: OPERATIONAL.
Despite the numerous approaches below, we have not been successful in identifying a recruitment pathway that would ensure feasibility of study continuation. We have had multiple meetings with CSR\&D leadership to discuss our study progress
Phase II Post-Traumatic Stress Disorders trial by VA Office of Research and Development. Stop reason: OTHER/UNKNOWN.
Early termination
Phase I Abdominal Aortic Aneurysm trial by VA Office of Research and Development. Stop reason: OPERATIONAL.
Early Termination as required by VA DSMB due to slow enrollment
Phase I Non-Small Cell Lung Cancer trial by VA Office of Research and Development. Stop reason: OPERATIONAL.
Low accrual
Phase II Menopause trial by VA Office of Research and Development. Stop reason: OTHER/UNKNOWN.
withdrawn
Phase IV Spinal Cord Injury trial by VA Office of Research and Development. Stop reason: OPERATIONAL.
Our ability to test subjects with tetraplegia in this interventional study was interrupted by the COVID-19 pandemic. Our research pharmacist also informed us that oral albuterol is no longer being manufactured.
Phase II Depressive Disorder trial by VA Office of Research and Development. Stop reason: SAFETY.
terminated early due to non-safety related DMC recommendations
Phase II Clostridium Difficile Infection trial by VA Office of Research and Development. Stop reason: EFFICACY/FUTILITY.
Study is terminated for futility per protocol-specified interim analysis and DMC recommendation.
Phase IV Dementia trial by VA Office of Research and Development. Stop reason: OPERATIONAL.
staffing issues and COVID
Phase IV Depressive Disorder, Major trial by VA Office of Research and Development. Stop reason: OPERATIONAL.
Study funding was withdrawn by study sponsor (CSR\&D) prior to enrollment due to budget constraints.
Phase II Spinal Cord Injury trial by VA Office of Research and Development. Stop reason: OPERATIONAL.
Enrollment difficulties
Unknown Diabetes Mellitus trial by VA Office of Research and Development. Stop reason: OPERATIONAL.
technical barriers to completing the original design within the funding period
Phase II Posttraumatic Stress Disorder trial by VA Office of Research and Development. Stop reason: OTHER/UNKNOWN.
PI obtained outside employment that was not compatible with this award
Phase IV Alcohol Use Disorder trial by VA Office of Research and Development. Stop reason: OPERATIONAL.
In ability to recruit
Phase II PTSD trial by VA Office of Research and Development. Stop reason: OPERATIONAL.
Use of VA hospital research space is indefinitely delayed due to prioritization of clinical cases delayed by COVID
Phase I Frailty trial by VA Office of Research and Development. Stop reason: OPERATIONAL.
Insufficient funding
Phase III COVID-19 trial by VA Office of Research and Development. Stop reason: OPERATIONAL.
DMC recommended early termination of enrollment
Phase II Chronic Hepatitis C trial by VA Office of Research and Development. Stop reason: OPERATIONAL.
Study Funding ended
Phase IV Chronic Kidney Disease trial by VA Office of Research and Development. Stop reason: OTHER/UNKNOWN.
The project has ended prior to beginning.
Phase I Mild to Moderate TBI trial by VA Office of Research and Development. Stop reason: REGULATORY.
Funding withdrawn due to delay in FDA IND submission
Early Phase I Renal Transplantation trial by VA Office of Research and Development. Stop reason: OPERATIONAL.
Due to COVID pandemic further recruitment of subjects was unethical.
Phase II Gulf War Illness trial by VA Office of Research and Development. Stop reason: OTHER/UNKNOWN.
Terminated by Funder
Phase III Alcohol Use Disorder trial by VA Office of Research and Development. Stop reason: OPERATIONAL.
Funding ended prematurely
Phase IV Anemia trial by VA Office of Research and Development. Stop reason: OPERATIONAL.
Lack of enrollment
Phase IV Asthma trial by VA Office of Research and Development. Stop reason: OPERATIONAL.
Low subject accrual
Phase IV Posttraumatic Stress Disorders trial by VA Office of Research and Development. Stop reason: OPERATIONAL.
Difficulty recruiting subjects and loss of study physician for new job
Phase II Cancer Cachexia trial by VA Office of Research and Development. Stop reason: OPERATIONAL.
poor recruitment
Phase II Diabetes trial by VA Office of Research and Development. Stop reason: OPERATIONAL.
Unable to reach accrual target.
Phase I Lung Cancer trial by VA Office of Research and Development. Stop reason: OTHER/UNKNOWN.
This study has been terminated, without having enrolled any participants
Phase I Non-Small Cell Lung Cancer (NSCLC) trial by VA Office of Research and Development. Stop reason: OTHER/UNKNOWN.
Estimated Primary Completion Date: March 2017 (Final data collection date for primary outcome measure)
Unknown Fatty Liver trial by VA Office of Research and Development. Stop reason: OPERATIONAL.
Low recruitment in intervention study. Baseline data published.
Phase I Schizophrenia trial by VA Office of Research and Development. Stop reason: OTHER/UNKNOWN.
Withdrawn
Phase IV Pain trial by VA Office of Research and Development. Stop reason: SAFETY.
Data safety monitoring board recommended due to low recruitment yield.
Unknown Psoriasis trial by VA Office of Research and Development. Stop reason: OPERATIONAL.
Recruiting complete and administrative termination
Phase III Central Apnea trial by VA Office of Research and Development. Stop reason: OPERATIONAL.
Patient recruitment and Funding inadequate to finish trial
Phase II Nicotine Use Disorder trial by VA Office of Research and Development. Stop reason: OPERATIONAL.
Enrollment was completed with insufficient sample size for publishable results