Sponsor hub
University of Texas Southwestern Medical Center clinical trial failures
Review 100 stopped clinical trials from University of Texas Southwestern Medical Center, including disease areas, phases, and classified stop reasons.
This page groups real ClinicalTrials.gov-derived stopped trial records. The strongest added signal is the stop-reason classification: 3 of these records are likely biological failure signals, while the rest may reflect operational, strategic, regulatory, funding, enrollment, or unclear stop reasons.
Dominant stop reasons
- OPERATIONAL
- 49
- OTHER/UNKNOWN
- 46
- EFFICACY/FUTILITY
- 3
- REGULATORY
- 2
Notable sponsors
- University of Texas Southwestern Medical Center
- 100
Related phases
- Phase II
- 35
- Phase I
- 26
- Phase IV
- 18
- Unknown
- 9
- Early Phase I
- 6
Crawlable stopped-trial records
Open ExploreShowing up to 100 representative records from this slice. Each link opens the trial detail page with source attribution and stop-reason context.
Phase III Osteoporosis trial by University of Texas Southwestern Medical Center. Stop reason: OPERATIONAL.
No enrollment due to COVID
Phase II Hepatocellular Carcinoma trial by University of Texas Southwestern Medical Center. Stop reason: OPERATIONAL.
The decision was made to close the study to enrollment due to poor overall accrual and the inability to meet the 31% overall enrollment goal.
Phase II Non Small Cell Lung Cancer trial by University of Texas Southwestern Medical Center. Stop reason: OPERATIONAL.
Sponsor decision to halt funding.
Phase IV Hemophilia A trial by University of Texas Southwestern Medical Center. Stop reason: OPERATIONAL.
Due to COVID-19 pandemic, recruitment was temporarily put on hold. We are withdrawing this registration due to a recent amendment to the protocol that includes major changes to data elements. A new registration will be submitted for the new protocol.
Phase IV Urinary Tract Infections trial by University of Texas Southwestern Medical Center. Stop reason: OTHER/UNKNOWN.
Because the study investigator is no longer following these patients as part of this study. They are followed as part of SOC as the study investigator's patients.
Phase I Congenital Adrenal Hyperplasia trial by University of Texas Southwestern Medical Center. Stop reason: OPERATIONAL.
The study has been affected significantly by the COVID pandemic, drug supply/drug amendment, low recruitment interest, and FDA approval of another drug with the same indication, so this study has not met its primary endpoint data requirements.
Phase III Leukemia trial by University of Texas Southwestern Medical Center. Stop reason: OPERATIONAL.
Study is closed with the IRB due to no funding. May resume once funding is obtained.
Phase II Long COVID trial by University of Texas Southwestern Medical Center. Stop reason: OPERATIONAL.
challenges with recruitment
Early Phase I GBM trial by University of Texas Southwestern Medical Center. Stop reason: OPERATIONAL.
Administratively closed by the IRB.
Phase II Brain Metastases from Non-small Cell Lung Cancer trial by University of Texas Southwestern Medical Center. Stop reason: OPERATIONAL.
Project Never Initiated since sponsor stopped support for the trial- no human subjects were enrolled and no data regarding humans was collected or studied
Phase I Non-small Cell Lung Cancer trial by University of Texas Southwestern Medical Center. Stop reason: OPERATIONAL.
Funding Sponsor no longer supporting study
Phase I Cancer of Pancreas trial by University of Texas Southwestern Medical Center. Stop reason: EFFICACY/FUTILITY.
The study was terminated due to futility and lack of future funding
Phase I Healthy trial by University of Texas Southwestern Medical Center. Stop reason: OPERATIONAL.
The focus of the laboratory went a different direction given extramural funding
Phase I Acute Appendicitis trial by University of Texas Southwestern Medical Center. Stop reason: OTHER/UNKNOWN.
Project did not receive final IRB approvals. PI decided to withdrawn research study.
Early Phase I Solid Tumor trial by University of Texas Southwestern Medical Center. Stop reason: OPERATIONAL.
Lack of accrual
Phase IV Surgical Site Infection trial by University of Texas Southwestern Medical Center. Stop reason: OPERATIONAL.
The study never initiated.
Phase I Cancer of Pancreas trial by University of Texas Southwestern Medical Center. Stop reason: OPERATIONAL.
Funding was terminated early because research interests were going in a different direction.
Phase IV Pain trial by University of Texas Southwestern Medical Center. Stop reason: OTHER/UNKNOWN.
The surgical team has difficulty to find level 1 and 2 fusions for the study.
Phase IV Breast Cancer trial by University of Texas Southwestern Medical Center. Stop reason: OPERATIONAL.
Low enrollment
Early Phase I Betel Nut Cessation trial by University of Texas Southwestern Medical Center. Stop reason: OTHER/UNKNOWN.
Have not received IRB approval.
Phase II Hepatocellular Carcinoma trial by University of Texas Southwestern Medical Center. Stop reason: OTHER/UNKNOWN.
Sponsor pulled support for one of the study drugs.
Phase IV Depression trial by University of Texas Southwestern Medical Center. Stop reason: OPERATIONAL.
terminated during COVID due to inability to see participants in person.
Unknown Rosacea trial by University of Texas Southwestern Medical Center. Stop reason: OTHER/UNKNOWN.
Plan to move forward with this study has been dropped
Phase IV Muscle Cramp trial by University of Texas Southwestern Medical Center. Stop reason: OTHER/UNKNOWN.
No grant obtained. Enrolled participants were not assigned to the intervention and was study terminated
Phase II ALK-positive Non-small Cell Lung Cancer trial by University of Texas Southwestern Medical Center. Stop reason: OTHER/UNKNOWN.
The study was terminated after UTSW was informed by Novartis that further support for the study would not be provided
Phase II Congenital Adrenal Hyperplasia trial by University of Texas Southwestern Medical Center. Stop reason: OTHER/UNKNOWN.
This study plan has halted and was withdrawn from the IRB.
Phase II Major Depressive Disorder trial by University of Texas Southwestern Medical Center. Stop reason: OPERATIONAL.
Covid-19
Phase III Osteoporosis trial by University of Texas Southwestern Medical Center. Stop reason: OPERATIONAL.
The study was terminated due to a severe decrease in enrollment over the years 2020 and 2021. The major obstacle which hindered participation of subjects was the COVID-19 pandemic. Research was halted. Remaining study patients were withdrawn.
Phase II Metastatic Clear Cell Renal Cell Carcinoma trial by University of Texas Southwestern Medical Center. Stop reason: OTHER/UNKNOWN.
Since the treatment landscape for metastatic kidney cancer changed, patients were not becoming eligible for this trial and therefore, the trial was terminated.
Phase IV Patients With a Diagnosis of Odynophonia trial by University of Texas Southwestern Medical Center. Stop reason: OPERATIONAL.
Halted prematurely prior to enrollment of first participant
Phase I Pancreatic Cancer trial by University of Texas Southwestern Medical Center. Stop reason: OPERATIONAL.
The study placed on temporarily hold to enrollment due to quality testing necessary for the study drug.
Unknown Acute Alcoholic Hepatitis trial by University of Texas Southwestern Medical Center. Stop reason: OPERATIONAL.
Lack of funding
Early Phase I Glioma trial by University of Texas Southwestern Medical Center. Stop reason: OTHER/UNKNOWN.
Drug availability
Phase II Autoimmune Encephalitis trial by University of Texas Southwestern Medical Center. Stop reason: OPERATIONAL.
Failed to meet target enrollment and study was discontinued
Phase I Post Traumatic Stress Disorder trial by University of Texas Southwestern Medical Center. Stop reason: OPERATIONAL.
Feasibility study was not initiated.
Phase II Type 1 Hyperlipoproteinemia trial by University of Texas Southwestern Medical Center. Stop reason: OTHER/UNKNOWN.
Due to unavailability of the drug.
Phase I Hypospadias trial by University of Texas Southwestern Medical Center. Stop reason: OPERATIONAL.
Limited funding and resources to complete FDA requirements for enrollment
Phase II Sickle Cell Disease and Thalassemia trial by University of Texas Southwestern Medical Center. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase IV Postoperative Pain trial by University of Texas Southwestern Medical Center. Stop reason: OPERATIONAL.
Unable to complete the sample size needed for 80% power due to changes in surgical approach to adductor block usage.
Early Phase I Pancreatic Cancer trial by University of Texas Southwestern Medical Center. Stop reason: OPERATIONAL.
no accrual for over 12 months
Phase II Hepatocellular Carcinoma trial by University of Texas Southwestern Medical Center. Stop reason: OTHER/UNKNOWN.
This study was terminated after the sponsor withdrew our support
Phase IV Thyroid Cancer trial by University of Texas Southwestern Medical Center. Stop reason: OTHER/UNKNOWN.
Terminating study as sponsor has sold the drug to another company
Phase II Vascular System Injuries trial by University of Texas Southwestern Medical Center. Stop reason: OTHER/UNKNOWN.
PI, Dr. Josh Gaston, left the institution and the study has been stopped.
Phase II Recurrent Epithelial Cancer of Ovary trial by University of Texas Southwestern Medical Center. Stop reason: OPERATIONAL.
low accrual
Phase I Anemia trial by University of Texas Southwestern Medical Center. Stop reason: OPERATIONAL.
Initial patients were seen at St Paul Hospital. Enrollment changes occurred with the move to Clements Hospital. We were unable to identify an infusion room at CUH despite an exhaustive search for alternatives and forced to terminate early.
Phase II Breast Cancer trial by University of Texas Southwestern Medical Center. Stop reason: OPERATIONAL.
Study sponsor requested that the study be permanently closed by letter.
Phase II Childhood Cancer trial by University of Texas Southwestern Medical Center. Stop reason: EFFICACY/FUTILITY.
Futility; unable to complete screening due to clinical practice change
Phase I Prostate Cancer trial by University of Texas Southwestern Medical Center. Stop reason: OTHER/UNKNOWN.
Overlapping study, PI preferred to enroll in alternate trial.
Phase II Melanoma trial by University of Texas Southwestern Medical Center. Stop reason: OPERATIONAL.
the project was never initiated and no participants were enrolled, it was closed permanently
Phase II METASTATIC BREAST CANCER trial by University of Texas Southwestern Medical Center. Stop reason: OPERATIONAL.
low accrual
Phase I Stage II Rectal Cancer trial by University of Texas Southwestern Medical Center. Stop reason: OTHER/UNKNOWN.
Drug shortage
Unknown Abdominal Pain trial by University of Texas Southwestern Medical Center. Stop reason: OPERATIONAL.
Unable to enroll more patients
Phase IV Acute Liver Failure trial by University of Texas Southwestern Medical Center. Stop reason: OTHER/UNKNOWN.
This observational study was stopped after 140 patients were enrolled, no more funds available to continue.
Phase IV Pulmonary Hypertension trial by University of Texas Southwestern Medical Center. Stop reason: OPERATIONAL.
Poor enrolment
Phase II Breast Cancer trial by University of Texas Southwestern Medical Center. Stop reason: OTHER/UNKNOWN.
Competing clinical trial
Phase I Cutaneous T-Cell Lymphomas trial by University of Texas Southwestern Medical Center. Stop reason: OPERATIONAL.
Unable to enroll patients that met enrollment criteria.
Phase II Leukemia trial by University of Texas Southwestern Medical Center. Stop reason: OPERATIONAL.
Poor accrual and difficulty with multicenter logistics
Phase III Chronic Pain trial by University of Texas Southwestern Medical Center. Stop reason: OPERATIONAL.
Lack of Funding
Phase II Post-ERCP Acute Pancreatitis trial by University of Texas Southwestern Medical Center. Stop reason: OPERATIONAL.
lack of funding
Phase II Burns trial by University of Texas Southwestern Medical Center. Stop reason: OTHER/UNKNOWN.
Xoma to no longer supply drug for the study
Phase II Thrombocytopenia trial by University of Texas Southwestern Medical Center. Stop reason: OTHER/UNKNOWN.
Interferon use for hepatitis C plummeted, eliminating the need for study drug.
Unknown Type 1 Diabetes trial by University of Texas Southwestern Medical Center. Stop reason: OTHER/UNKNOWN.
Presumed loss of clinical equipoise between the agents being investigated
Phase I Lymphoma trial by University of Texas Southwestern Medical Center. Stop reason: OPERATIONAL.
Project Never Initiated - no human subjects were enrolled and no data regarding humans was collected or studied
Phase I Type 1 Diabetes trial by University of Texas Southwestern Medical Center. Stop reason: OPERATIONAL.
Sponsor request
Phase II Metastatic Anaplastic Thyroid Cancer trial by University of Texas Southwestern Medical Center. Stop reason: OTHER/UNKNOWN.
study was on hold for protocol redesign; decided to not move forward with study.
Phase III Major Depressive Disorder trial by University of Texas Southwestern Medical Center. Stop reason: OPERATIONAL.
Enrollment discontinued based on mutually agreed upon decision by PI and funding sponsor
Unknown Cystic Fibrosis trial by University of Texas Southwestern Medical Center. Stop reason: OTHER/UNKNOWN.
D Hardin not at institution, IRB has no record, no other investigators for study information
Phase II Severe Thermal Injury, Greater Than 20% TBSA trial by University of Texas Southwestern Medical Center. Stop reason: REGULATORY.
This potential study was held up at the level of the FDA as they wouldn't approve and IND for the dose of vitamin C we wanted to use.
Phase I Head and Neck Cancer trial by University of Texas Southwestern Medical Center. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase I Pre-hypertension trial by University of Texas Southwestern Medical Center. Stop reason: OTHER/UNKNOWN.
none enrolled per PI
Phase I Pancreatic Cancer trial by University of Texas Southwestern Medical Center. Stop reason: OTHER/UNKNOWN.
DSMC closed due to patient deaths
Phase II Breast Cancer trial by University of Texas Southwestern Medical Center. Stop reason: OPERATIONAL.
accrual goal not met
Unknown Pharmacokinetics trial by University of Texas Southwestern Medical Center. Stop reason: OTHER/UNKNOWN.
Unable to obtain FDA approval
Phase II Cervix Uteri--Diseases trial by University of Texas Southwestern Medical Center. Stop reason: REGULATORY.
FDA has withdrawn the IND application- requesting protocol changes
Phase IV Metabolic Syndrome trial by University of Texas Southwestern Medical Center. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase IV Abdominal Surgery Patients trial by University of Texas Southwestern Medical Center. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase IV Type 2 Diabetes trial by University of Texas Southwestern Medical Center. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase I Cocaine Induced Sympathoexciation and Vasoconstriction trial by University of Texas Southwestern Medical Center. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase I Lung Cancer trial by University of Texas Southwestern Medical Center. Stop reason: OTHER/UNKNOWN.
Withdrawn as the sponsor has stopped the drug for NSCLC population
Unknown Cystic Fibrosis Related Diabetes trial by University of Texas Southwestern Medical Center. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase II Cystic Fibrosis trial by University of Texas Southwestern Medical Center. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase IV Liver Disease trial by University of Texas Southwestern Medical Center. Stop reason: OPERATIONAL.
failure to recruit
Phase IV Type 1 Diabetes trial by University of Texas Southwestern Medical Center. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase II HIV Infection trial by University of Texas Southwestern Medical Center. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase III Phantom Pain trial by University of Texas Southwestern Medical Center. Stop reason: OTHER/UNKNOWN.
Preoperative period is very short time
Phase I Congestive Heart Failure trial by University of Texas Southwestern Medical Center. Stop reason: OTHER/UNKNOWN.
eIRB closed, no patient enrolled
Unknown Hurler Syndrome trial by University of Texas Southwestern Medical Center. Stop reason: OTHER/UNKNOWN.
Record Owner no longer with the institution
Phase II Lymphoma trial by University of Texas Southwestern Medical Center. Stop reason: OPERATIONAL.
Slow accrual.
Unknown Dry Eye Syndrome trial by University of Texas Southwestern Medical Center. Stop reason: OTHER/UNKNOWN.
The PI has elected to terminate study at this time
Phase II Brain and Central Nervous System Tumors trial by University of Texas Southwestern Medical Center. Stop reason: EFFICACY/FUTILITY.
MyVax did not meet its primary endpoints
Early Phase I Pancreatic Cancer trial by University of Texas Southwestern Medical Center. Stop reason: OPERATIONAL.
low accrual
Phase II Peripheral Nerve Tumors trial by University of Texas Southwestern Medical Center. Stop reason: OPERATIONAL.
Lack of enrollment.
Phase I Melanoma trial by University of Texas Southwestern Medical Center. Stop reason: OPERATIONAL.
No subjects consented for enrollment on this study.
Phase I Ovarian Cancer trial by University of Texas Southwestern Medical Center. Stop reason: OPERATIONAL.
Funding source withdrew funding
Phase IV Delirium trial by University of Texas Southwestern Medical Center. Stop reason: OPERATIONAL.
Stopped the study due to feasibility issues, no enrollment has taken place.
Phase II Glioma trial by University of Texas Southwestern Medical Center. Stop reason: OTHER/UNKNOWN.
Sponsor did not want to move forward with protocol; study was never opened.
Phase I Melanoma trial by University of Texas Southwestern Medical Center. Stop reason: OTHER/UNKNOWN.
standard of care improved combination treatment of ipilimumab plus nivolumab.
Phase II Multiple Sclerosis (MS) trial by University of Texas Southwestern Medical Center. Stop reason: OTHER/UNKNOWN.
sponsor stopped
Phase I Sedation trial by University of Texas Southwestern Medical Center. Stop reason: OPERATIONAL.
Poor recruitement
Phase I HIV Lipodystrophy trial by University of Texas Southwestern Medical Center. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.