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University of North Carolina, Chapel Hill clinical trial failures
Review 51 stopped clinical trials from University of North Carolina, Chapel Hill, including disease areas, phases, and classified stop reasons.
This page groups real ClinicalTrials.gov-derived stopped trial records. The strongest added signal is the stop-reason classification: 3 of these records are likely biological failure signals, while the rest may reflect operational, strategic, regulatory, funding, enrollment, or unclear stop reasons.
Dominant stop reasons
- OPERATIONAL
- 37
- OTHER/UNKNOWN
- 11
- EFFICACY/FUTILITY
- 2
- SAFETY
- 1
Notable sponsors
- University of North Carolina, Chapel Hill
- 51
Related phases
- Phase II
- 17
- Phase I
- 15
- Phase IV
- 10
- Early Phase I
- 5
- Phase III
- 2
Crawlable stopped-trial records
Open ExploreShowing up to 51 representative records from this slice. Each link opens the trial detail page with source attribution and stop-reason context.
Phase II Chronic Pain Following Thermal Burn Injury trial by University of North Carolina, Chapel Hill. Stop reason: OPERATIONAL.
COVID-19 global pandemic, and study funding period ended 7/31/2020.
Phase IV Opioid Use Disorder trial by University of North Carolina, Chapel Hill. Stop reason: OPERATIONAL.
Inability to recruit participants
Phase I Obesity trial by University of North Carolina, Chapel Hill. Stop reason: OPERATIONAL.
Lack of funding
Phase IV Brain Injuries, Acute trial by University of North Carolina, Chapel Hill. Stop reason: OPERATIONAL.
Low recruitment
Phase II Crohn Disease trial by University of North Carolina, Chapel Hill. Stop reason: OPERATIONAL.
The DSMB concluded that feasibility endpoints were reached in time for Week 4 but no participants receiving standard of care dietary treatment could be randomized based on the at-risk of the microbiome signature.
Phase I Healthy Volunteers trial by University of North Carolina, Chapel Hill. Stop reason: OPERATIONAL.
Suspended due to COVID-19. Protocol did not resume post COVID due to funding.
Phase II Sickle Cell Disease Without Crisis trial by University of North Carolina, Chapel Hill. Stop reason: OPERATIONAL.
Funding not renewed
Phase II Pouchitis trial by University of North Carolina, Chapel Hill. Stop reason: OPERATIONAL.
Due to an interruption in drug supply, the study was terminated
Phase IV Borderline Personality Disorder trial by University of North Carolina, Chapel Hill. Stop reason: OTHER/UNKNOWN.
Changed study design and it is no longer a clinical trial.
Phase II Covid19 trial by University of North Carolina, Chapel Hill. Stop reason: OPERATIONAL.
The team decided to terminate the trial in order to start a new trial, unrelated to safety reasons
Phase III Diabetes trial by University of North Carolina, Chapel Hill. Stop reason: EFFICACY/FUTILITY.
Recommendation by the DSMB that the study be stopped for futility
Early Phase I Anorexia Nervosa trial by University of North Carolina, Chapel Hill. Stop reason: OPERATIONAL.
Withdrawn due to covid-19 protocols on inpatient eating disorders unit.
Early Phase I Asthma trial by University of North Carolina, Chapel Hill. Stop reason: OPERATIONAL.
Terminated due to COVID-19 pandemic.
Early Phase I Asthma Atopic trial by University of North Carolina, Chapel Hill. Stop reason: OPERATIONAL.
Terminated due to COVID-19 pandemic.
Phase II Bulimia Nervosa trial by University of North Carolina, Chapel Hill. Stop reason: OPERATIONAL.
Halted prematurely due to COVID-19-related enrollment challenges.
Phase I Asthma, Allergic trial by University of North Carolina, Chapel Hill. Stop reason: OPERATIONAL.
Study stopped due to COVID-19 pandemic.
Phase II Pituitary Tumor trial by University of North Carolina, Chapel Hill. Stop reason: OPERATIONAL.
Challenges in recruitment
Phase II COVID19 trial by University of North Carolina, Chapel Hill. Stop reason: OPERATIONAL.
Funding withdrawn
Phase IV FSGS trial by University of North Carolina, Chapel Hill. Stop reason: OPERATIONAL.
Funding terminated prematurely
Phase I Healthy Participants trial by University of North Carolina, Chapel Hill. Stop reason: OPERATIONAL.
Lack of funding
Phase I Asthma trial by University of North Carolina, Chapel Hill. Stop reason: OPERATIONAL.
\[The risk of inhaled allergen challenge and anakinra treatment outweigh benefits to participants with allergic asthma due to the COVID-19 pandemic.
Phase I Tobacco Smoking trial by University of North Carolina, Chapel Hill. Stop reason: OPERATIONAL.
Lack of funding
Phase I Asthma trial by University of North Carolina, Chapel Hill. Stop reason: OPERATIONAL.
The risk of inhaled allergen challenge and anakinra treatment outweigh benefits to participants with allergic asthma due to the COVID-19 pandemic.
Phase IV Perimenopausal Disorder trial by University of North Carolina, Chapel Hill. Stop reason: OPERATIONAL.
In-person visit restrictions due to COVID-19
Phase IV Schizophrenia trial by University of North Carolina, Chapel Hill. Stop reason: OTHER/UNKNOWN.
The FDA advised of a possible health risk associated with lorcaserin and the drug is being withdrawn.
Early Phase I Benign Prostatic Hyperplasia trial by University of North Carolina, Chapel Hill. Stop reason: OPERATIONAL.
Lack of funding
Early Phase I Cystic Fibrosis trial by University of North Carolina, Chapel Hill. Stop reason: OPERATIONAL.
Enrollment barriers made study completion impossible
Unknown Tooth Fractures trial by University of North Carolina, Chapel Hill. Stop reason: OPERATIONAL.
Difficulty in recruitment
Phase II Alcohol Use Disorder trial by University of North Carolina, Chapel Hill. Stop reason: OTHER/UNKNOWN.
PI no longer employed at Institution
Phase I HIV-1 Infection trial by University of North Carolina, Chapel Hill. Stop reason: OTHER/UNKNOWN.
Manufacturing of the AGS-004 HIV vaccine by Argos could no longer be provided.
Phase II Respiratory Distress Syndrome, Adult trial by University of North Carolina, Chapel Hill. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase II Fecal Incontinence trial by University of North Carolina, Chapel Hill. Stop reason: OPERATIONAL.
Difficult to recruit severely affected patients with fecal incontinence
Phase I Pouchitis trial by University of North Carolina, Chapel Hill. Stop reason: EFFICACY/FUTILITY.
Due low efficacy of FMT in interim analysis.
Phase IV Endodontic Disease trial by University of North Carolina, Chapel Hill. Stop reason: OTHER/UNKNOWN.
study drug not available in time
Phase I Headache trial by University of North Carolina, Chapel Hill. Stop reason: OPERATIONAL.
PI left institution.
Phase I Peanut Allergy trial by University of North Carolina, Chapel Hill. Stop reason: OPERATIONAL.
Lack of funding
Phase IV Acute Decompensated Heart Failure trial by University of North Carolina, Chapel Hill. Stop reason: OPERATIONAL.
Difficult recruitment
Phase IV Acute HIV Infection trial by University of North Carolina, Chapel Hill. Stop reason: OPERATIONAL.
Study halted by sponsor due to slow enrollment.
Phase IV Post Operative Pain Control trial by University of North Carolina, Chapel Hill. Stop reason: OPERATIONAL.
Insufficient infrastructure/funding for enrollment
Phase II Cystic Fibrosis trial by University of North Carolina, Chapel Hill. Stop reason: SAFETY.
Interim review showed a statistically significant treatment effect and the DMC recommended that the study be stopped with ongoing follow-up of enrolled subjects
Phase I Dermatophagoides Farinae Allergy trial by University of North Carolina, Chapel Hill. Stop reason: OPERATIONAL.
Original PI left institution.
Phase I Rotator Cuff Tear trial by University of North Carolina, Chapel Hill. Stop reason: OPERATIONAL.
Did not meet target enrollment deadlines.
Phase II Acne trial by University of North Carolina, Chapel Hill. Stop reason: OPERATIONAL.
lack of funding due to Celgene administrative decision
Phase II Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis trial by University of North Carolina, Chapel Hill. Stop reason: OTHER/UNKNOWN.
no subject enrolled in nearly 2 years
Phase II Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis trial by University of North Carolina, Chapel Hill. Stop reason: OTHER/UNKNOWN.
the study failed to enroll any patient and sponsor wished to stop.
Unknown Fecal Incontinence trial by University of North Carolina, Chapel Hill. Stop reason: OPERATIONAL.
Low enrollment led sponsor to terminate study early.
Phase I Nut Hypersensitivities trial by University of North Carolina, Chapel Hill. Stop reason: OTHER/UNKNOWN.
Concern for cross contamination in weighing tree nuts in facility with peanuts
Phase II Pulmonary Hypertension trial by University of North Carolina, Chapel Hill. Stop reason: OTHER/UNKNOWN.
Difficulty in accruing subjects
Phase III Pain trial by University of North Carolina, Chapel Hill. Stop reason: OTHER/UNKNOWN.
terminated by PI
Phase II Olfaction Disorders trial by University of North Carolina, Chapel Hill. Stop reason: OPERATIONAL.
Difficulty recruiting
Phase I Healthy trial by University of North Carolina, Chapel Hill. Stop reason: OPERATIONAL.
Lack of funding