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University of California, San Francisco clinical trial failures
Review 119 stopped clinical trials from University of California, San Francisco, including disease areas, phases, and classified stop reasons.
This page groups real ClinicalTrials.gov-derived stopped trial records. The strongest added signal is the stop-reason classification: 6 of these records are likely biological failure signals, while the rest may reflect operational, strategic, regulatory, funding, enrollment, or unclear stop reasons.
Dominant stop reasons
- OPERATIONAL
- 71
- OTHER/UNKNOWN
- 41
- EFFICACY/FUTILITY
- 4
- SAFETY
- 2
- REGULATORY
- 1
Notable sponsors
- University of California, San Francisco
- 119
Related phases
- Phase II
- 49
- Phase IV
- 30
- Phase I
- 28
- Unknown
- 7
- Phase III
- 4
Crawlable stopped-trial records
Open ExploreShowing up to 100 representative records from this slice. Each link opens the trial detail page with source attribution and stop-reason context.
Phase IV Post-traumatic Stress Disorder trial by University of California, San Francisco. Stop reason: OPERATIONAL.
Unable to meet enrollment goals
Phase IV Appendicitis trial by University of California, San Francisco. Stop reason: OPERATIONAL.
Not feasible to complete trial due to low enrollment rate. Enrollment terminated and inadequately powered to achieve statistical significance on primary and secondary study outcomes.
Phase I Sleep Disorders trial by University of California, San Francisco. Stop reason: OPERATIONAL.
Lack of funding
Phase IV Sarcoidosis trial by University of California, San Francisco. Stop reason: OTHER/UNKNOWN.
sponsor closed study down
Phase IV Trachoma trial by University of California, San Francisco. Stop reason: OPERATIONAL.
Study withdrawn (no participants enrolled) due to resources.
Phase II Cytomegalovirus Anterior Uveitis trial by University of California, San Francisco. Stop reason: OPERATIONAL.
Funding discontinued.
Phase IV Menstrual Regulation trial by University of California, San Francisco. Stop reason: OPERATIONAL.
Lack of successful recruitment and loss of funding
Phase II Hypertension trial by University of California, San Francisco. Stop reason: OPERATIONAL.
Funding limitations.
Phase II Metastatic Clear Cell Renal Cell Carcinoma trial by University of California, San Francisco. Stop reason: OPERATIONAL.
Collaborating sponsor decision
Phase IV Breast Cancer trial by University of California, San Francisco. Stop reason: OPERATIONAL.
Slow Accrual
Phase I Parkinson Disease trial by University of California, San Francisco. Stop reason: EFFICACY/FUTILITY.
Conducting an interim analysis
Phase II Cystinuria trial by University of California, San Francisco. Stop reason: OPERATIONAL.
Funding was never secured so clinical trial was never started; this study was abandoned
Phase I Obesity trial by University of California, San Francisco. Stop reason: OPERATIONAL.
No funding
Phase IV Dry Eye trial by University of California, San Francisco. Stop reason: OPERATIONAL.
Lack of funding
Phase I Psoriasis Vulgaris trial by University of California, San Francisco. Stop reason: OPERATIONAL.
Closing of the Goeckerman program at UCSF and loss of funding, PI left UCSF
Phase II Acute Kidney Injury trial by University of California, San Francisco. Stop reason: OPERATIONAL.
Investigator Left Institution
Phase IV Resistance Bacterial trial by University of California, San Francisco. Stop reason: OTHER/UNKNOWN.
AVENIR I demonstrated efficacy of azithromycin MDA targeted to children 1-59 over 1-11 months in July 2023, thus this trial was stopped before outcomes were collected so Niger could expand the program nationally to include children 1-59 months.
Phase I Metastatic Melanoma trial by University of California, San Francisco. Stop reason: OPERATIONAL.
Sponsor decision
Phase I Opioid-use Disorder trial by University of California, San Francisco. Stop reason: OPERATIONAL.
The COVID-19 Pandemic prevented us from meeting target goals.
Phase III Severe Acute Malnutrition trial by University of California, San Francisco. Stop reason: OTHER/UNKNOWN.
Study was halted due to low follow-up rates and issues with data collection
Phase I Alpha Thalassemia Major trial by University of California, San Francisco. Stop reason: OPERATIONAL.
Enrollment ended early due to interim data suggesting a lack of efficacy. Interim data did demonstrate that IUHSCT was safe and well tolerated, but the PI and DSMB agreed that enrollment should not continue under the current treatment protocol.
Phase I Locally Advanced Soft Tissue Sarcoma trial by University of California, San Francisco. Stop reason: OPERATIONAL.
Business decision
Phase II Head and Neck Squamous Cell Carcinoma trial by University of California, San Francisco. Stop reason: OPERATIONAL.
Low accrual
Phase II Transplant-Associated Thrombotic Microangiopathy trial by University of California, San Francisco. Stop reason: OPERATIONAL.
Industry sponsor decision
Phase II Recurrent Plasma Cell Myeloma trial by University of California, San Francisco. Stop reason: OPERATIONAL.
Slow enrollment and change in sponsor direction
Phase I HIV trial by University of California, San Francisco. Stop reason: OPERATIONAL.
Pause on clinical trial enrollment due to grant funding cuts after COVID-19
Phase II COVID-19 trial by University of California, San Francisco. Stop reason: OPERATIONAL.
The funder decided not to continue funding, causing enrollment to cease prematurely and curtailing originally planned analyses. Participants with any samples collected after the baseline pre-rinse samples were included in the analysis.
Phase II Oral Lichen Planus trial by University of California, San Francisco. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase II Covid19 trial by University of California, San Francisco. Stop reason: OPERATIONAL.
Low COVID case numbers, competing COVID treatments available
Phase II Anatomic Stage IV Breast Cancer AJCC v8 trial by University of California, San Francisco. Stop reason: OTHER/UNKNOWN.
Change in practice patterns
Unknown Glaucoma trial by University of California, San Francisco. Stop reason: OTHER/UNKNOWN.
The necessary ethical approvals were not obtained in a timely manner.
Phase IV Alcohol Use Disorder trial by University of California, San Francisco. Stop reason: OPERATIONAL.
12 month follow up data not collected due to pandemic disruptions
Phase IV Postoperative Pain trial by University of California, San Francisco. Stop reason: OTHER/UNKNOWN.
The study was terminated due to not enough power and research staff assistance.
Phase II Gastrointestinal Carcinoid Tumor trial by University of California, San Francisco. Stop reason: OPERATIONAL.
Low accrual
Phase IV Acute Kidney Injury trial by University of California, San Francisco. Stop reason: OPERATIONAL.
Inadequate recruitment
Phase II Malaria, Vivax trial by University of California, San Francisco. Stop reason: OTHER/UNKNOWN.
Trial terminated by funder
Phase IV Symptomatic Irreversible Pulpitis trial by University of California, San Francisco. Stop reason: OTHER/UNKNOWN.
Study activities never commenced.
Phase I Metastatic Colon Adenocarcinoma trial by University of California, San Francisco. Stop reason: OPERATIONAL.
Sponsor funding
Phase II Low Grade Glioma trial by University of California, San Francisco. Stop reason: OPERATIONAL.
Sponsor decision
Phase I Non-small Cell Lung Cancer trial by University of California, San Francisco. Stop reason: OPERATIONAL.
Low Accrual
Phase IV Transplantation trial by University of California, San Francisco. Stop reason: REGULATORY.
Because of inability to get FDA approval for
Phase I ALK Gene Rearrangement trial by University of California, San Francisco. Stop reason: OPERATIONAL.
Low Accrual
Phase I Opioid-use Disorder trial by University of California, San Francisco. Stop reason: OPERATIONAL.
The COVID-19 pandemic and recruitment difficulties prompted the investigators to terminate study early.
Phase I Oral Leukoplakia trial by University of California, San Francisco. Stop reason: OTHER/UNKNOWN.
Principal Investigator no longer with university.
Unknown Glaucoma trial by University of California, San Francisco. Stop reason: OPERATIONAL.
low recruitment
Phase II Ultrasonography trial by University of California, San Francisco. Stop reason: OTHER/UNKNOWN.
The research team submitted grants over the course of several years to gain funds to support this research but were unsuccessful in securing the funds. The research team will now focus on other funded studies.
Phase II Infection trial by University of California, San Francisco. Stop reason: OPERATIONAL.
Study has never started as sponsor did not approve for funding.
Phase IV Pancreatitis trial by University of California, San Francisco. Stop reason: OPERATIONAL.
Lack of Funding
Phase II Coccidioidomycosis trial by University of California, San Francisco. Stop reason: OTHER/UNKNOWN.
failure to enroll
Phase II Lung Non-Small Cell Carcinoma trial by University of California, San Francisco. Stop reason: OPERATIONAL.
Low Accrual
Phase IV Asthma trial by University of California, San Francisco. Stop reason: OTHER/UNKNOWN.
The study was redesigned to be conducted in an outpatient setting.
Phase II Prostatic Neoplasms trial by University of California, San Francisco. Stop reason: OPERATIONAL.
Low Accrual
Phase IV Pterygium of Conjunctiva and Cornea trial by University of California, San Francisco. Stop reason: OPERATIONAL.
Funding not received.
Phase II Thyroid Gland Carcinoma trial by University of California, San Francisco. Stop reason: OPERATIONAL.
Funding
Phase IV Helminth Infection trial by University of California, San Francisco. Stop reason: OTHER/UNKNOWN.
We were not able to secure IRB approval in the timeline necessary to do this study.
Phase IV Diminished Ovarian Reserve trial by University of California, San Francisco. Stop reason: OPERATIONAL.
Slow enrollment resulted in withdraw of funding
Phase IV PCOS trial by University of California, San Francisco. Stop reason: OPERATIONAL.
Recruitment challenges
Phase II Infertility trial by University of California, San Francisco. Stop reason: OPERATIONAL.
Low recruitment and competing studies have published.
Phase IV Hernia, Diaphragmatic trial by University of California, San Francisco. Stop reason: OTHER/UNKNOWN.
Change in clinical practice allowing chronic therapy at 6 weeks of age, incompatible with possibility of placebo beyond 6 weeks of age on study protocol
Phase IV Uveitis trial by University of California, San Francisco. Stop reason: OTHER/UNKNOWN.
Difficulty enrolling
Phase II Breast Cancer trial by University of California, San Francisco. Stop reason: OPERATIONAL.
Low Accrual
Phase II Neuroendocrine Tumors trial by University of California, San Francisco. Stop reason: OPERATIONAL.
Low Accrual
Phase II Diabetic Macular Edema trial by University of California, San Francisco. Stop reason: OPERATIONAL.
Study not feasible with current resources.
Phase I Stage 0 Bladder Urothelial Carcinoma AJCC v6 and v7 trial by University of California, San Francisco. Stop reason: OTHER/UNKNOWN.
Investigators prefer to pursue other studies
Phase II Irreversible Pulpitis trial by University of California, San Francisco. Stop reason: OTHER/UNKNOWN.
Did not obtain IRB approval
Phase II Prostate Adenocarcinoma trial by University of California, San Francisco. Stop reason: OPERATIONAL.
Funding
Phase II Breast Neoplasms trial by University of California, San Francisco. Stop reason: EFFICACY/FUTILITY.
Insufficient efficacy in an unselected patient population
Phase I Multiple Myeloma trial by University of California, San Francisco. Stop reason: OPERATIONAL.
Low Accrual
Phase I Heart Septal Defects, Ventricular trial by University of California, San Francisco. Stop reason: OTHER/UNKNOWN.
Changes to cardiac surgery program
Phase II Peripheral T-Cell Lymphoma trial by University of California, San Francisco. Stop reason: OTHER/UNKNOWN.
Manufacturing shortage of both Diftitox and Doxil
Phase IV Schizophrenia trial by University of California, San Francisco. Stop reason: OPERATIONAL.
Insufficient Funds and Inadequate Subject Recruitment
Phase I Advanced Intra-Ocular Retinoblastoma trial by University of California, San Francisco. Stop reason: OPERATIONAL.
Low accrual
Phase II Esophageal Cancer trial by University of California, San Francisco. Stop reason: OPERATIONAL.
For slow accrual
Phase II Myeloid Malignancy trial by University of California, San Francisco. Stop reason: EFFICACY/FUTILITY.
Triggering of futility rule; Interim analysis suggested no statistical superiority over historic controls
Phase IV Chronic Sinusitis trial by University of California, San Francisco. Stop reason: OPERATIONAL.
Insufficient funds available
Phase II ALK Fusion Protein Expression trial by University of California, San Francisco. Stop reason: OPERATIONAL.
Funding
Phase I Statin Pharmacokinetics Pre and Post Gastric Bypass Surgery trial by University of California, San Francisco. Stop reason: OTHER/UNKNOWN.
IRB approval expired
Phase I Breast Cancer trial by University of California, San Francisco. Stop reason: OTHER/UNKNOWN.
Risk to benefit ratio not acceptable
Phase I Primary Tauopathies trial by University of California, San Francisco. Stop reason: OTHER/UNKNOWN.
BIIB092 program discontinued
Phase II Non-small Cell Lung Cancer trial by University of California, San Francisco. Stop reason: OPERATIONAL.
Low Accrual
Phase I Neuroendocrine Tumor trial by University of California, San Francisco. Stop reason: OPERATIONAL.
FDA approved agent for this indication during enrollment
Phase II Non-small Cell Lung Cancer trial by University of California, San Francisco. Stop reason: OPERATIONAL.
Low Accrual
Phase II Lymphoma, Large B-Cell, Diffuse trial by University of California, San Francisco. Stop reason: OTHER/UNKNOWN.
Unexpected dose production issues prevented study start up
Phase II Breast Cancer trial by University of California, San Francisco. Stop reason: OPERATIONAL.
Low accrual.
Phase IV Asthma trial by University of California, San Francisco. Stop reason: OTHER/UNKNOWN.
The study was closed after we determined that this albuterol/NAC regimen may be associated with excessive bronchoconstriction.
Phase III Dyslipidemia trial by University of California, San Francisco. Stop reason: OTHER/UNKNOWN.
Industry won't be moving forward with production of bococizumab
Phase IV Hepatitis C, Chronic trial by University of California, San Francisco. Stop reason: OTHER/UNKNOWN.
never opened
Phase IV Early Abortion trial by University of California, San Francisco. Stop reason: OTHER/UNKNOWN.
The study is not proceeding at this time.
Phase II Glioma trial by University of California, San Francisco. Stop reason: OTHER/UNKNOWN.
The primary objective for high grade gliomas has been met and the FDA has now approved the drug (Gleolan) for use in the United States.
Unknown Laryngeal Stenosis trial by University of California, San Francisco. Stop reason: OPERATIONAL.
Due to poor patient accrual, the study was closed prior to reaching the desired study size
Phase IV Plaque Psoriasis trial by University of California, San Francisco. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Unknown Postoperative Pain trial by University of California, San Francisco. Stop reason: OTHER/UNKNOWN.
Preliminary results showed no ability to predict pain by measuring hippus with pupillometry
Phase I Gastroesophageal Reflux trial by University of California, San Francisco. Stop reason: OPERATIONAL.
Difficulty recruiting; Funding ended; interim analysis provided sufficient data for interpretation.
Phase IV Dermatitis, Atopic trial by University of California, San Francisco. Stop reason: OPERATIONAL.
Unable to meet the study's recruitment goals
Phase I Autism Disorder trial by University of California, San Francisco. Stop reason: OTHER/UNKNOWN.
unable to launch the study due to lack of participation with Autism Clinic
Phase IV Insulin Resistance trial by University of California, San Francisco. Stop reason: OPERATIONAL.
No funding
Phase II Infiltrating Bladder Urothelial Carcinoma trial by University of California, San Francisco. Stop reason: OPERATIONAL.
Study withdrawn prior to patient enrollment
Phase III Ischemic Attack, Transient trial by University of California, San Francisco. Stop reason: SAFETY.
The trial was halted by the DSMB.
Early Phase I Prostate Cancer trial by University of California, San Francisco. Stop reason: OPERATIONAL.
Low accrual
Phase II Severe Combined Immunodeficiency trial by University of California, San Francisco. Stop reason: OTHER/UNKNOWN.
Insufficient evidence of efficacy