University of California, Los Angeles clinical trial failures

Unknown Growth Failure trial by University of California, Los Angeles. Stop reason: OPERATIONAL.

The sponsor has notified us that they are not funding the study

Early Phase I Cocaine Use Disorder trial by University of California, Los Angeles. Stop reason: OTHER/UNKNOWN.

Departmental support

Phase II Pulmonary Embolism trial by University of California, Los Angeles. Stop reason: OTHER/UNKNOWN.

no sponsor support

Early Phase I Endodontic Disease trial by University of California, Los Angeles. Stop reason: OPERATIONAL.

Enrollment difficulties

Unknown Arterial Occlusion trial by University of California, Los Angeles. Stop reason: OPERATIONAL.

Initiating PI left our institution.

Phase II PTSD, Post Traumatic Stress Disorder trial by University of California, Los Angeles. Stop reason: OTHER/UNKNOWN.

Under review with FDA

Phase I Lung Transplant Recipient trial by University of California, Los Angeles. Stop reason: OPERATIONAL.

Moderna Bivalent COVID-19 Vaccine became available to the public in Sept 2022.

Phase IV Dyspnea trial by University of California, Los Angeles. Stop reason: EFFICACY/FUTILITY.

Conducted an interim analysis on similar data

Unknown Epilepsy trial by University of California, Los Angeles. Stop reason: OPERATIONAL.

not funded

Unknown Schizophrenia, Treatment-Resistant trial by University of California, Los Angeles. Stop reason: OTHER/UNKNOWN.

Action of PI. Loss of sponsor

Phase I Dopamine D2/3 Receptor Availability trial by University of California, Los Angeles. Stop reason: OPERATIONAL.

Global pandemic

Phase II Hepatorenal Syndrome trial by University of California, Los Angeles. Stop reason: OPERATIONAL.

Funding issues; the study was never started

Phase IV Glaucoma Open-Angle Primary trial by University of California, Los Angeles. Stop reason: OPERATIONAL.

Problems unique to COVID-19, incomplete data due to a high rate of dropout to minimize non-essential appointments and difficult subject recruitment

Phase IV Schizophrenia trial by University of California, Los Angeles. Stop reason: OPERATIONAL.

Withdraw of financial support by industry collaborator

Early Phase I Stimulant Use trial by University of California, Los Angeles. Stop reason: OPERATIONAL.

Study never initiated

Early Phase I Depression trial by University of California, Los Angeles. Stop reason: OPERATIONAL.

COVID-19

Phase IV Hypothyroidism trial by University of California, Los Angeles. Stop reason: OPERATIONAL.

Sponsor terminated study low accrual numbers

Phase IV Ischemic Stroke trial by University of California, Los Angeles. Stop reason: OPERATIONAL.

Funding Discontinued

Early Phase I Dry Eyes Chronic trial by University of California, Los Angeles. Stop reason: OPERATIONAL.

Lack of funding/support

Phase IV Surgical Site Infection trial by University of California, Los Angeles. Stop reason: OPERATIONAL.

Do not have adequate funding to proceed with project.

Phase II Severe Combined Immunodeficiency Due to ADA Deficiency trial by University of California, Los Angeles. Stop reason: OPERATIONAL.

Recruitment on hold for business reasons. Study will not be performed.

Unknown Virtual Reality trial by University of California, Los Angeles. Stop reason: OPERATIONAL.

No patients enrolled

Phase II Brain Injuries, Traumatic trial by University of California, Los Angeles. Stop reason: OTHER/UNKNOWN.

The manufacturer of sodium lactate has stopped making the medication

Early Phase I Depression trial by University of California, Los Angeles. Stop reason: OPERATIONAL.

COVID-19

Phase IV Thyroid Eye Disease trial by University of California, Los Angeles. Stop reason: OPERATIONAL.

recruitment challenges

Phase II Stroke trial by University of California, Los Angeles. Stop reason: OPERATIONAL.

Poor recruitment for each site, partly related to Covid epidemic.

Phase II Alcohol Use Disorder trial by University of California, Los Angeles. Stop reason: OPERATIONAL.

Project was not funded.

Phase I Systemic Lupus Erythematosus Arthritis trial by University of California, Los Angeles. Stop reason: EFFICACY/FUTILITY.

Response rate in placebo group for primary outcome was 100% on interim analysis.

Phase I Laparoscopic Myomectomy trial by University of California, Los Angeles. Stop reason: OTHER/UNKNOWN.

Closed prior to completion secondary to surgeon leaving UCLA

Phase IV Lung Transplant Rejection trial by University of California, Los Angeles. Stop reason: OTHER/UNKNOWN.

No stop-reason text available in the compact dataset.

Unknown Rheumatoid Arthritis trial by University of California, Los Angeles. Stop reason: OPERATIONAL.

The study team did not enroll any patients due to difficulty with recruitment.

Phase II Episodic Ataxia Type 2 trial by University of California, Los Angeles. Stop reason: OTHER/UNKNOWN.

No stop-reason text available in the compact dataset.

Phase II Intracerebral Hemorrhage trial by University of California, Los Angeles. Stop reason: OPERATIONAL.

The funding period for the study has ended.

Phase IV Cardiac Disease trial by University of California, Los Angeles. Stop reason: OTHER/UNKNOWN.

Poor study design and too many study groups.

Phase III Lung Transplant trial by University of California, Los Angeles. Stop reason: OPERATIONAL.

lack of enrollment

Phase I Methamphetamine Use Disorder trial by University of California, Los Angeles. Stop reason: OPERATIONAL.

Deemed unable to enroll targeted participants in part due to COVID-19 shut downs

Phase I Autism Spectrum Disorder trial by University of California, Los Angeles. Stop reason: OPERATIONAL.

COVID

Phase II Cholestasis trial by University of California, Los Angeles. Stop reason: OTHER/UNKNOWN.

study intervention was approved by the FDA

Phase II Multiple Sclerosis trial by University of California, Los Angeles. Stop reason: OPERATIONAL.

Lack of funding

Early Phase I Enterobacteriaceae Infections trial by University of California, Los Angeles. Stop reason: OPERATIONAL.

Investigator left the institution

Phase III Hypercholesterolemia trial by University of California, Los Angeles. Stop reason: OPERATIONAL.

Unable to obtain supplement for this study. Unable to recruit.

Phase I Alcohol Use Disorder trial by University of California, Los Angeles. Stop reason: OPERATIONAL.

Investigator left institution prior to enrollment of study participants

Phase II Cholesterol Lowering trial by University of California, Los Angeles. Stop reason: OTHER/UNKNOWN.

We were unable to procure the supplement for this study.

Early Phase I Cognitive Dysfunction trial by University of California, Los Angeles. Stop reason: OPERATIONAL.

Study withdrawn. No participants enrolled.

Phase IV Hepatitis C trial by University of California, Los Angeles. Stop reason: OPERATIONAL.

Funding no longer available

Phase IV C.Surgical Procedure trial by University of California, Los Angeles. Stop reason: OPERATIONAL.

Study was never initiated.

Phase IV Cigarette Smoking trial by University of California, Los Angeles. Stop reason: OPERATIONAL.

Investigator left institution prior to enrollment of study participants

Phase IV Pulmonary Arterial Hypertension trial by University of California, Los Angeles. Stop reason: OPERATIONAL.

inclusion/exclusion criteria limited enrollment

Phase I Crohn's Disease trial by University of California, Los Angeles. Stop reason: OPERATIONAL.

Low enrollment

Phase III Parkinson's Disease trial by University of California, Los Angeles. Stop reason: OTHER/UNKNOWN.

Prevalence of H Pylori in the study population was much lower than anticipated

Unknown Congenital Heart Disease trial by University of California, Los Angeles. Stop reason: OPERATIONAL.

slow enrollment

Phase I Methamphetamine Abuse trial by University of California, Los Angeles. Stop reason: OPERATIONAL.

End in funding

Phase III Analgesic Affect trial by University of California, Los Angeles. Stop reason: OTHER/UNKNOWN.

unknown - no record of study conduct in departmental archive

Phase IV Face Pain trial by University of California, Los Angeles. Stop reason: OTHER/UNKNOWN.

Lack of eligible patients willing and able to participate

Phase I Pro-inflammatory Activity trial by University of California, Los Angeles. Stop reason: OPERATIONAL.

Unable to recruit prescription opioid abusers; ultimately no potential POA recruit passed the pre-screening process

Phase IV Emergence Agitation trial by University of California, Los Angeles. Stop reason: EFFICACY/FUTILITY.

Interim analysis revealed a negative effect.

Phase IV Pregnancy trial by University of California, Los Angeles. Stop reason: OPERATIONAL.

Poor Enrollment

Phase IV Chronic Obstructive Pulmonary Disease trial by University of California, Los Angeles. Stop reason: OPERATIONAL.

Sponsor withdrew funding prior to study initiation

Phase II Multiple Sclerosis trial by University of California, Los Angeles. Stop reason: OPERATIONAL.

NIH did not fund the study so it never started

Phase I Myopic Macular Degeneration trial by University of California, Los Angeles. Stop reason: OTHER/UNKNOWN.

Study to be revised. Future plans to be determined.

Phase IV Cholestasis trial by University of California, Los Angeles. Stop reason: OPERATIONAL.

The study was terminated due to slow enrollment.

Phase I Substance-Related Disorders trial by University of California, Los Angeles. Stop reason: OPERATIONAL.

Unable to recruit adaquate number of GHB dependent subjects

Phase IV Apoptotic DNA Damage trial by University of California, Los Angeles. Stop reason: OTHER/UNKNOWN.

The PI has left UCLA and we do not plan to pursue this study.

Early Phase I Crohn's Disease trial by University of California, Los Angeles. Stop reason: OTHER/UNKNOWN.

patients insurance would not cover the cost of the study procedures

Unknown Atopic Dermatitis trial by University of California, Los Angeles. Stop reason: OPERATIONAL.

Inadequate funding to support this fellow-in-training initiated study.

Phase II Schizophrenia trial by University of California, Los Angeles. Stop reason: OTHER/UNKNOWN.

Study terminated at Sponsor's request.

Unknown Pulmonary Arterial Hypertension trial by University of California, Los Angeles. Stop reason: OPERATIONAL.

enrollment was too slow