University of California, Davis clinical trial failures

Phase I Advanced Colorectal Carcinoma trial by University of California, Davis. Stop reason: EFFICACY/FUTILITY.

For internal interim analysis

Phase I Advanced Adenocarcinoma trial by University of California, Davis. Stop reason: SAFETY.

Drugs unavailable

Phase II Locally Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck trial by University of California, Davis. Stop reason: OPERATIONAL.

Slow accrual

Phase II ATM Gene Mutation trial by University of California, Davis. Stop reason: OPERATIONAL.

PI choice; poor accrual

Phase II Non Hodgkin's Lymphoma trial by University of California, Davis. Stop reason: OTHER/UNKNOWN.

Sponsor choice

Phase IV Vertebral Compression Fracture trial by University of California, Davis. Stop reason: OPERATIONAL.

Difficulty recruiting members

Phase II Lymphoma trial by University of California, Davis. Stop reason: OPERATIONAL.

Poor accrual

Phase I Solid Tumor, Childhood trial by University of California, Davis. Stop reason: OTHER/UNKNOWN.

PI discretion; suspended while CAPA is reviewed

Phase II Opioid-use Disorder trial by University of California, Davis. Stop reason: OPERATIONAL.

This study was not funded and therefore not recruiting. So we never opened the study.

Phase I Soft Tissue Sarcoma trial by University of California, Davis. Stop reason: OTHER/UNKNOWN.

PI choice.

Phase III Bullous Pemphigoid trial by University of California, Davis. Stop reason: OPERATIONAL.

PI did not pursue this study; this study was not IRB-approved and never started.

Phase I Asthma trial by University of California, Davis. Stop reason: OPERATIONAL.

Enrollment stopped secondary to completion of funding

Phase II Melanoma trial by University of California, Davis. Stop reason: OPERATIONAL.

low enrollment

Phase II Second Trimester Abortion trial by University of California, Davis. Stop reason: OPERATIONAL.

Slow recruitment compounded by COVID-19

Early Phase I Advanced Lung Non-Small Cell Carcinoma trial by University of California, Davis. Stop reason: OPERATIONAL.

Unable to recruit to study.

Phase IV Epistaxis trial by University of California, Davis. Stop reason: OPERATIONAL.

Terminate due to slow enrollment rate.

Unknown Post-operative Pain trial by University of California, Davis. Stop reason: OPERATIONAL.

Poor enrollment

Phase III Cancer of Head and Neck trial by University of California, Davis. Stop reason: OPERATIONAL.

Poor Recruitment

Phase II Hormone-Resistant Prostate Cancer trial by University of California, Davis. Stop reason: OPERATIONAL.

Poor accrual of subjects onto study

Phase IV Hypoactive Delirium trial by University of California, Davis. Stop reason: EFFICACY/FUTILITY.

A planned interim analysis led to the trial being stopped early based on the observed size effect and power analysis.

Phase IV Hemophilia A With Inhibitor trial by University of California, Davis. Stop reason: OPERATIONAL.

Termination of funding from sponsor.

Phase I Pregnancy, Unwanted trial by University of California, Davis. Stop reason: OTHER/UNKNOWN.

Safety

Phase IV Attention Deficit Hyperactivity Disorder trial by University of California, Davis. Stop reason: OPERATIONAL.

Lack of enrollment

Phase I Toxic Epidermal Necrolysis trial by University of California, Davis. Stop reason: OPERATIONAL.

Lack of enrollment

Phase IV Vomiting trial by University of California, Davis. Stop reason: OPERATIONAL.

recruitment futility

Phase II Suicide trial by University of California, Davis. Stop reason: OPERATIONAL.

Trial never received funding.

Phase I Multiple Sclerosis trial by University of California, Davis. Stop reason: OPERATIONAL.

Unable to complete subject recruitment

Phase I Breast Cancer trial by University of California, Davis. Stop reason: OTHER/UNKNOWN.

Practice patterns with pemetrexed have evolved.

Phase I Lung Cancer trial by University of California, Davis. Stop reason: OTHER/UNKNOWN.

Number of known toxicities observed despite a treatment-naïve population

Phase II Adult Brain Glioblastoma trial by University of California, Davis. Stop reason: OPERATIONAL.

Poor Accrual

Early Phase I Carcinoma, Non-Small-Cell Lung trial by University of California, Davis. Stop reason: OTHER/UNKNOWN.

Contract ended

Unknown Metastatic Cancer trial by University of California, Davis. Stop reason: OTHER/UNKNOWN.

No stop-reason text available in the compact dataset.

Phase II Severe Asthma trial by University of California, Davis. Stop reason: OTHER/UNKNOWN.

No stop-reason text available in the compact dataset.

Phase I Primary Sclerosing Cholangitis trial by University of California, Davis. Stop reason: OPERATIONAL.

Lack of feasibility

Phase II Diabetes Complications trial by University of California, Davis. Stop reason: OPERATIONAL.

Lack of recruitment

Phase II Colorectal Cancer trial by University of California, Davis. Stop reason: OPERATIONAL.

Lack of accrual

Unknown Epilepsy trial by University of California, Davis. Stop reason: OPERATIONAL.

our site was unable to enroll any qualified subjects

Phase IV Abnormal Uterine Bleeding, Unspecified trial by University of California, Davis. Stop reason: OPERATIONAL.

Futility of recruitment

Phase III Hayfever trial by University of California, Davis. Stop reason: OPERATIONAL.

Sponsor suspended study do to funding

Phase IV Atopic Dermatitis trial by University of California, Davis. Stop reason: OTHER/UNKNOWN.

withdrawn due to contractual issues

Phase II Ulcer trial by University of California, Davis. Stop reason: OPERATIONAL.

Lack of funding.