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University of Alabama at Birmingham clinical trial failures
Review 108 stopped clinical trials from University of Alabama at Birmingham, including disease areas, phases, and classified stop reasons.
This page groups real ClinicalTrials.gov-derived stopped trial records. The strongest added signal is the stop-reason classification: 3 of these records are likely biological failure signals, while the rest may reflect operational, strategic, regulatory, funding, enrollment, or unclear stop reasons.
Dominant stop reasons
- OPERATIONAL
- 62
- OTHER/UNKNOWN
- 42
- EFFICACY/FUTILITY
- 2
- REGULATORY
- 1
- SAFETY
- 1
Notable sponsors
- University of Alabama at Birmingham
- 108
Related phases
- Phase II
- 30
- Phase I
- 26
- Phase IV
- 20
- Unknown
- 13
- Early Phase I
- 10
Crawlable stopped-trial records
Open ExploreShowing up to 100 representative records from this slice. Each link opens the trial detail page with source attribution and stop-reason context.
Phase I HER2-positive Breast Cancer trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
Unable to recruit for this study.
Phase I Cutaneous T Cell Lymphoma trial by University of Alabama at Birmingham. Stop reason: OTHER/UNKNOWN.
IRB audit
Phase I Ovarian Cancer Recurrent trial by University of Alabama at Birmingham. Stop reason: OTHER/UNKNOWN.
never opened
Phase I Critical Asymptomatic Carotid Artery Disease trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
Recruitment issues
Phase I Fibromyalgia trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
Lost funding.
Phase IV Parathyroid Dysfunction trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
Funding halted
Phase I T-cell Lymphoma trial by University of Alabama at Birmingham. Stop reason: OTHER/UNKNOWN.
Ipsen, drug company requested all studies using the drug Taxemetostat be terminated due to increased risk of secondary malignancies in subjects.
Early Phase I Demoralization trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
Sponsor terminated contract due to insufficient funding.
Phase IV Obstetric trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
Ran out of funding
Phase II Kidney Cancer trial by University of Alabama at Birmingham. Stop reason: OTHER/UNKNOWN.
due to overall cost of the study
Unknown Overactive Bladder Syndrome trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
Not funded by industry
Phase I Recurrent Malignant Glioma trial by University of Alabama at Birmingham. Stop reason: OTHER/UNKNOWN.
Not enough eligible participants to enroll.
Phase II Acute Pain trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
No funding for this project
Phase III Neonatal Asphyxia trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
Funding not obtained
Phase III Intrapartum Fetal Distress trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
Funding not obtained
Phase II Metastatic Breast Cancer trial by University of Alabama at Birmingham. Stop reason: REGULATORY.
Study accrual ended early due to the FDA approval of tucatinib in metastatic HER2+ breast cancer
Phase I Pain trial by University of Alabama at Birmingham. Stop reason: OTHER/UNKNOWN.
Study withdran per PI's request
Early Phase I Opioid Dependence trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
Study was never initiated.
Phase I Diffuse Large B Cell Lymphoma trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
Investigator request to no longer pursue this study. Lack of support from drug company. This trial never opened. Withdrew IND.
Phase II SCCHN trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
No staff or funding to do the study.
Phase IV Cystic Fibrosis trial by University of Alabama at Birmingham. Stop reason: EFFICACY/FUTILITY.
summary results revealed ineffective intervention and the trial was terminated prematurely. No formal statistical analysis was performed
Phase IV Prescription Stimulants trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
Did not receive funding
Phase II NF1 trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
The closure of the study is due to the lack of enrollment and the lack of evaluable patients.
Phase II Prostate Cancer trial by University of Alabama at Birmingham. Stop reason: OTHER/UNKNOWN.
Abemaciclib efficacy
Phase IV Dry Eye trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
COVID disruptions to recruitment and study completion, unforeseen staffing and other issues
Phase IV Depressive Disorder trial by University of Alabama at Birmingham. Stop reason: OTHER/UNKNOWN.
study never opened
Phase I Metastatic Colon Cancer trial by University of Alabama at Birmingham. Stop reason: OTHER/UNKNOWN.
Study was not able to enroll any subjects
Early Phase I Mitral Valve Regurgitation trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
lack of recruitment and PI departure
Phase I Cholangiocarcinoma trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
Slow accrual and study sponsor decision.
Phase I Breast Cancer trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
lack of recruitment and funding
Early Phase I Prostate Cancer trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
Recruitment was difficult.
Phase IV Pain trial by University of Alabama at Birmingham. Stop reason: EFFICACY/FUTILITY.
Futility analysis at midpoint analysis
Phase I Non-melanoma Skin Cancer trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
COVID-19 pandemic, unable to enroll participants
Phase II Obesity trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
Funding
Phase I Macrophage Activation Syndrome trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
no further funding to continue, investigator relocated, no replacement found to continue
Phase IV Synkinesis trial by University of Alabama at Birmingham. Stop reason: OTHER/UNKNOWN.
The project never opened.
Phase I Ovarian Cancer trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
No recruitment/enrollment and funding expired.
Phase II Anemia, Sickle Cell trial by University of Alabama at Birmingham. Stop reason: OTHER/UNKNOWN.
Estimated GFR was determined not to be a reliable endpoint for this study. We identified significant variabilty in annual eGFR that it became inappropriate to randomize to a medication but use EGFR as the primary endpoint.
Phase II Non-alcoholic Fatty Liver Disease (NAFLD) trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
Astra Zeneca notified Dr. Rita Basu that they will not manufacture new drug due to business reasons and study was stopped.
Early Phase I Validation of a New Noninvasive Method to Obtain the Arterial Input Function (AIF) Directly by PET Imaging trial by University of Alabama at Birmingham. Stop reason: OTHER/UNKNOWN.
The investigator decided not to pursue the study.
Early Phase I Pediatric Brain Tumors trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
Insufficient recruitment
Phase I Ovarian Cancer trial by University of Alabama at Birmingham. Stop reason: OTHER/UNKNOWN.
will not resume. company choosing not to continue with drug. one participant now off study.
Phase I Mantle Cell Lymphoma trial by University of Alabama at Birmingham. Stop reason: OTHER/UNKNOWN.
FDA hold
Early Phase I Neuroendocrine Carcinoma of Pancreas trial by University of Alabama at Birmingham. Stop reason: OTHER/UNKNOWN.
no partipants
Phase IV Trauma trial by University of Alabama at Birmingham. Stop reason: OTHER/UNKNOWN.
Transition/change of primary investigators
Phase I Acute Decompensated Heart Failure trial by University of Alabama at Birmingham. Stop reason: OTHER/UNKNOWN.
The study was not able to enroll any eligible subjects.
Phase I Cerebral Edema trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
Slow accrual
Unknown Fatigue Syndrome, Chronic trial by University of Alabama at Birmingham. Stop reason: OTHER/UNKNOWN.
Study was temporarily suspended to focus on other projects, but was never resumed. No participants were determined eligible and none started the protocol.
Phase II Penile Squamous Cell Carcinoma trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
Poor accrual
Unknown Partial Tear of Rotator Cuff trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
Study terminated prematurely due to inability to complete recruitment of subjects for each of the trial groups (treatment and control).
Phase IV Surgical Site Infection trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
Funding issues, poor recruiting and compliance of the patients.
Phase IV Chronic Bronchitis trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
no participants enrolled
Phase II Chronic Obstructive Pulmonary Disease trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
Study never started due to change in availability of study drug
Phase II Pregnancy Related trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
Lack of recruitment due to COVID-19 pandemic; chloroprocaine shortage
Unknown Osteoarthritis of the Shoulder trial by University of Alabama at Birmingham. Stop reason: OTHER/UNKNOWN.
Failure of institution to reach agreement with company supplying injections
Phase III Masked Hypertension trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
lack of funding
Phase IV Treatment Resistant Depression trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
Investigator decided not to do study, due to insufficient funding.
Phase II Head and Neck Cancer trial by University of Alabama at Birmingham. Stop reason: SAFETY.
Sponsor terminated study due to higher incidence of pulmonary toxicity than expected, including death
Phase II COVID-19 trial by University of Alabama at Birmingham. Stop reason: OTHER/UNKNOWN.
Widespread vaccine availability
Phase IV Pain Management trial by University of Alabama at Birmingham. Stop reason: OTHER/UNKNOWN.
This protocol was difficult to enroll into, and changes to personnel have made it difficult to main this study. Data collection was not completed and therefore, no data analysis was performed. The PI has made the decision to close this study.
Phase II Post Surgical Pain trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
Low enrollment; recruitment challenges due to competing studies in women and infant center
Phase II Refractory Epilepsy trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
Low eligibility of patients, no successful recruitment
Phase II COVID-19 trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
Lack of recruitment
Early Phase I Gynecologic Cancer trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
Recruitment challenges due to COVID-19
Phase II COVID19 trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
Due to ongoing vaccination efforts, feasibility for recruitment is low
Phase III COVID-19 trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
With vaccination efforts ongoing, a feasibility survey indicated there would be inadequate recruitment
Phase II Carcinosarcoma of Ovary trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
Funding withdrawn by sponsor
Phase II Hepatocellular Carcinoma trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
study was terminated due to poor enrollment
Phase II Diabetes trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
Lack of eligible subjects, lack of staffing
Phase I Metastatic Prostate Cancer trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
PI left the institution
Phase II Chemotherapy-induced Nausea and Vomiting trial by University of Alabama at Birmingham. Stop reason: OTHER/UNKNOWN.
sponsor withdrew study
Early Phase I Locally Advanced Pancreatic Cancer trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
PI left the institution; no further accruals
Early Phase I Inflammatory Bowel Diseases trial by University of Alabama at Birmingham. Stop reason: OTHER/UNKNOWN.
never enrolled
Unknown Hypertensive trial by University of Alabama at Birmingham. Stop reason: OTHER/UNKNOWN.
Change in priority of interventional protocols
Phase II Penile Squamous Cell Carcinoma (PSCC) trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
poor overall accrual
Phase II Sleep Apnea trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
Recruitment challenges
Phase III Opioid-Related Disorders trial by University of Alabama at Birmingham. Stop reason: OTHER/UNKNOWN.
Infeasible to conduct at this time.
Unknown Glioma trial by University of Alabama at Birmingham. Stop reason: OTHER/UNKNOWN.
PI is leaving institution
Phase II Root Canal Therapy trial by University of Alabama at Birmingham. Stop reason: OTHER/UNKNOWN.
Withdrawn-was not approved by IRB
Phase IV Ocular Discomfort trial by University of Alabama at Birmingham. Stop reason: OTHER/UNKNOWN.
Study timing was poor.
Unknown Overactive Bladder trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
Poor enrollment
Phase IV Keratoconjunctivitis Sicca trial by University of Alabama at Birmingham. Stop reason: OTHER/UNKNOWN.
Change of direction
Phase IV Contact Lens Dry Eye trial by University of Alabama at Birmingham. Stop reason: OTHER/UNKNOWN.
no longer interest / resources to start study
Phase III Acute Kidney Injury trial by University of Alabama at Birmingham. Stop reason: OTHER/UNKNOWN.
Principal Investigator made aware of similar studies that have already been published.
Phase III Pain, Postoperative trial by University of Alabama at Birmingham. Stop reason: OTHER/UNKNOWN.
Principal investigator determination
Phase III Pain, Postoperative trial by University of Alabama at Birmingham. Stop reason: OTHER/UNKNOWN.
Principal investigator was unable to pursue research further due to time constraints.
Phase IV CKD trial by University of Alabama at Birmingham. Stop reason: OTHER/UNKNOWN.
Study didn't materialize for various reasons.
Phase IV Type 2 Diabetes Mellitus trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
Study closed by sponsor. Funding ended.
Phase II Multiple Myeloma trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
Accrual goals could not be met within a timely manner
Phase IV Type 2 Diabetes Mellitus trial by University of Alabama at Birmingham. Stop reason: OTHER/UNKNOWN.
unavailability of study drug and matching placebo
Phase II Pancreatic Cancer trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
Sponsor stopped due to slow enrollment
Phase I Bacteria Infection trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
Enrollment was terminated early due to a change in practice on the obstetrical side that included administering azithromycin to women with preterm labor.
Phase IV Diabetes trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
Sponsor requested termination.
Unknown Hepatocellular Carcinoma trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
Sponsor(Bayer)did not wish to continue with study due to slow accrual. Therefore, there is insufficient data and will not be any study results/outcomes.
Phase II Coagulopathy trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
Inability to recruit patients that meet inclusion criteria.
Phase III Venous Thrombosis trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
Problems with accrual
Phase II Uterine Cancer trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
low accrual
Phase I Pain trial by University of Alabama at Birmingham. Stop reason: OTHER/UNKNOWN.
failure to enroll
Unknown Tumor trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
poor accrual
Phase I Herpes Simplex Virus trial by University of Alabama at Birmingham. Stop reason: OTHER/UNKNOWN.
Study terminated because unable to obtain access to study drug for study population.