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The Cleveland Clinic clinical trial failures
Review 65 stopped clinical trials from The Cleveland Clinic, including disease areas, phases, and classified stop reasons.
This page groups real ClinicalTrials.gov-derived stopped trial records. The strongest added signal is the stop-reason classification: 4 of these records are likely biological failure signals, while the rest may reflect operational, strategic, regulatory, funding, enrollment, or unclear stop reasons.
Dominant stop reasons
- OPERATIONAL
- 35
- OTHER/UNKNOWN
- 26
- EFFICACY/FUTILITY
- 4
Notable sponsors
- The Cleveland Clinic
- 65
Related phases
- Unknown
- 25
- Phase IV
- 18
- Phase II
- 8
- Phase I
- 7
- Phase III
- 4
Crawlable stopped-trial records
Open ExploreShowing up to 65 representative records from this slice. Each link opens the trial detail page with source attribution and stop-reason context.
Phase I Ulcerative Colitis trial by The Cleveland Clinic. Stop reason: OPERATIONAL.
PI left Cleveland Clinic
Phase I Crohn Colitis trial by The Cleveland Clinic. Stop reason: OPERATIONAL.
PI left Cleveland Clinic
Phase I Pouchitis trial by The Cleveland Clinic. Stop reason: OPERATIONAL.
PI decision not to move forward with study.
Phase I Crohn's Disease trial by The Cleveland Clinic. Stop reason: OTHER/UNKNOWN.
This clinical trial was entered in error. Please refer to the correct entry of this study using the following link: https://clinicaltrials.gov/ct2/show/NCT04519684
Unknown Surgery trial by The Cleveland Clinic. Stop reason: OPERATIONAL.
Study Sponsor Decision
Phase IV Congestive Heart Failure trial by The Cleveland Clinic. Stop reason: OPERATIONAL.
unable to reach enrollment goal
Phase IV Type 2 Diabetes trial by The Cleveland Clinic. Stop reason: EFFICACY/FUTILITY.
After an unplanned yet IRB approved interim analysis, it was found that there was not a significant difference between the 3 arms of the study. The study was closed due to futility. All Patients are off study and this study will not resume.
Unknown Abdominal Hysterectomy (& Wertheim) trial by The Cleveland Clinic. Stop reason: OPERATIONAL.
Study was terminated per Principal Investigator decision.
Phase IV Knee Arthroscopy trial by The Cleveland Clinic. Stop reason: OPERATIONAL.
For practical reasons of slow enrollment
Unknown Inguinal Hernia Repair trial by The Cleveland Clinic. Stop reason: OPERATIONAL.
no enrollment
Phase IV Back Pain trial by The Cleveland Clinic. Stop reason: OPERATIONAL.
The study was terminated early due to a number of concurrent issues: low enrollment, limited data and COVID-19.
Phase IV Diabetic Ketoacidosis trial by The Cleveland Clinic. Stop reason: OTHER/UNKNOWN.
Stopped after internal review
Phase III Actinic Keratosis trial by The Cleveland Clinic. Stop reason: OTHER/UNKNOWN.
study drug no longer available in the United States
Phase II Radiation Retinopathy trial by The Cleveland Clinic. Stop reason: OPERATIONAL.
Lack of funding
Phase IV Cardiac Amyloidosis trial by The Cleveland Clinic. Stop reason: OPERATIONAL.
Low enrollment
Phase II Vulvodynia trial by The Cleveland Clinic. Stop reason: OPERATIONAL.
Not feasible due to low accrual
Phase II Peripheral Arterial Disease trial by The Cleveland Clinic. Stop reason: OPERATIONAL.
Lack of enrollment
Phase IV Bowel Preparation Solutions trial by The Cleveland Clinic. Stop reason: OPERATIONAL.
Low enrollment due to difficult eligibility criteria and participant prep logistics
Unknown Complex Regional Pain Syndrome (CRPS) trial by The Cleveland Clinic. Stop reason: OTHER/UNKNOWN.
Study halted prematurely and will not resume; participants are no longer being examined or receiving intervention. There is no data collected
Phase IV Sarcoidosis trial by The Cleveland Clinic. Stop reason: OPERATIONAL.
Difficulty with recruitment
Phase IV Diabetes Mellitus, Type 2 trial by The Cleveland Clinic. Stop reason: OPERATIONAL.
Study was terminated due to difficulty with reaching enrollment goals
Phase IV Cardiogenic Shock trial by The Cleveland Clinic. Stop reason: OTHER/UNKNOWN.
New study initiated
Phase II Discoid Lupus Erthematosus of the Scalp trial by The Cleveland Clinic. Stop reason: OTHER/UNKNOWN.
inadequate number of enrolled study subjects
Unknown Quality of Life trial by The Cleveland Clinic. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Unknown Atrial Fibrillation trial by The Cleveland Clinic. Stop reason: OPERATIONAL.
Problem with enrollment
Phase I Septic Shock trial by The Cleveland Clinic. Stop reason: OTHER/UNKNOWN.
No participant enrolled
Unknown Pain trial by The Cleveland Clinic. Stop reason: OPERATIONAL.
Enrollment challenges prohibited study progression.
Unknown Partial Nephrectomy trial by The Cleveland Clinic. Stop reason: EFFICACY/FUTILITY.
Executive committee determined to close study after interim analysis.
Unknown Aortic Valve Disorder trial by The Cleveland Clinic. Stop reason: OPERATIONAL.
Poor enrollment
Unknown Abdominal Surgery trial by The Cleveland Clinic. Stop reason: OPERATIONAL.
No patients enrolled
Unknown Obesity trial by The Cleveland Clinic. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase IV Septic Shock trial by The Cleveland Clinic. Stop reason: OPERATIONAL.
Difficulty in recruiting eligible subjects
Phase II Leukemia trial by The Cleveland Clinic. Stop reason: OTHER/UNKNOWN.
If \</= 5 of the initial 18 patients had a CR, the study would be stopped. Only 5 patients (21%) of 24 enrolled patients had a CR so the study was terminated.
Phase I Aplastic Anemia trial by The Cleveland Clinic. Stop reason: OTHER/UNKNOWN.
Study drug not available at this time
Phase I Cancer trial by The Cleveland Clinic. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Unknown Endometriosis trial by The Cleveland Clinic. Stop reason: OPERATIONAL.
no participants enrolled
Unknown Lumbar Laminectomy trial by The Cleveland Clinic. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Unknown Congenital Heart Surgery trial by The Cleveland Clinic. Stop reason: OTHER/UNKNOWN.
New protocol now being used for cardiopulmonary bypass
Unknown Catheter-Associated Urinary Tract Infection trial by The Cleveland Clinic. Stop reason: OPERATIONAL.
Unfeasible because of low accrual
Phase II Carotid Artery Disease trial by The Cleveland Clinic. Stop reason: OPERATIONAL.
Investigator left instititution
Phase IV Post-operative Ileus trial by The Cleveland Clinic. Stop reason: OPERATIONAL.
Study has been terminated due linability to recruit the targeted participants. Aimed for 300 participants and only 4 were enrolled after 1 year.
Phase IV Carotid Artery Stenosis trial by The Cleveland Clinic. Stop reason: OPERATIONAL.
Closed due to lack of enrollment
Phase IV HIV Infection trial by The Cleveland Clinic. Stop reason: OPERATIONAL.
Closed due to low enrollment
Phase IV Aortic Valve Stenosis trial by The Cleveland Clinic. Stop reason: OTHER/UNKNOWN.
Poor Reducibility - primary endpoint measure not obtainable
Unknown Abdominal Hysterectomy (& Wertheim) trial by The Cleveland Clinic. Stop reason: EFFICACY/FUTILITY.
Futility
Unknown Pain trial by The Cleveland Clinic. Stop reason: OTHER/UNKNOWN.
Collected study data was not usable due to process miscommunications
Phase III Kidney Transplant trial by The Cleveland Clinic. Stop reason: OTHER/UNKNOWN.
Collaborator stopped study
Unknown Non Ulcer Dyspepsia trial by The Cleveland Clinic. Stop reason: OPERATIONAL.
Not enough participants - only 5 since the study started
Unknown Anesthesia, Local trial by The Cleveland Clinic. Stop reason: EFFICACY/FUTILITY.
A strong primary outcome crosses the efficacy boundary at the interim analysis
Unknown Brain Neoplasms trial by The Cleveland Clinic. Stop reason: OPERATIONAL.
PI decision to terminate. No usable data collected
Unknown Impaired Airway Clearance trial by The Cleveland Clinic. Stop reason: OTHER/UNKNOWN.
sponsor has decided not to support this study.
Phase IV Autogenous Bone Grafts trial by The Cleveland Clinic. Stop reason: OPERATIONAL.
No participants enrolled
Phase III Chronic Kidney Disease Stage 3 and 4 trial by The Cleveland Clinic. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Unknown Mild Cognitive Disorder trial by The Cleveland Clinic. Stop reason: OTHER/UNKNOWN.
Study revised to use a different study medication and patient population.
Phase IV Myocardial Injury trial by The Cleveland Clinic. Stop reason: OPERATIONAL.
Enrollment expectations were not met
Phase IV Diastolic Heart Failure trial by The Cleveland Clinic. Stop reason: OTHER/UNKNOWN.
Lack of eligible patients
Early Phase I Pulmonary Insufficiency trial by The Cleveland Clinic. Stop reason: OPERATIONAL.
Investigator left institution
Early Phase I Chalazia trial by The Cleveland Clinic. Stop reason: OPERATIONAL.
Investigator left the institution
Phase II Primary Sjogren's Syndrome trial by The Cleveland Clinic. Stop reason: OPERATIONAL.
No Enrollment
Early Phase I Non-melanomatous Skin Cancer trial by The Cleveland Clinic. Stop reason: OTHER/UNKNOWN.
Of the 8 histologically proven tumors, detection of PpIX proved to be ambiguous.
Unknown Migraine Disorders trial by The Cleveland Clinic. Stop reason: OPERATIONAL.
No participants enrolled
Unknown Colon Cancer trial by The Cleveland Clinic. Stop reason: OTHER/UNKNOWN.
investigator could not identify any patients
Unknown Varicose Vein trial by The Cleveland Clinic. Stop reason: OTHER/UNKNOWN.
Enrolling of participants has halted and the results are being gathered
Phase III Cancer trial by The Cleveland Clinic. Stop reason: OTHER/UNKNOWN.
Lack of study population
Phase II Pulmonary Alveolar Proteinosis trial by The Cleveland Clinic. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.