SWOG Cancer Research Network clinical trial failures

Review 26 stopped clinical trials from SWOG Cancer Research Network, including disease areas, phases, and classified stop reasons.

This page groups real ClinicalTrials.gov-derived stopped trial records. The strongest added signal is the stop-reason classification: 3 of these records are likely biological failure signals, while the rest may reflect operational, strategic, regulatory, funding, enrollment, or unclear stop reasons.

Total stopped trials26

Likely biological signals3

Shown below26

Dominant stop reasons

OPERATIONAL: 16
OTHER/UNKNOWN: 7
EFFICACY/FUTILITY: 2
SAFETY: 1

Notable sponsors

SWOG Cancer Research Network: 26

Related phases

Phase II: 16
Phase III: 6
Phase I: 3
Unknown: 1

Crawlable stopped-trial records

Open Explore

Showing up to 26 representative records from this slice. Each link opens the trial detail page with source attribution and stop-reason context.

NCT04871529: Testing the Addition of an Anti-Cancer Immunotherapy Drug, Avelumab, to Gemcitabine and Carboplatin Chemotherapy Prior to Surgery in Muscle Invasive Urinary Tract Cancer vs. Surgery Alone in Patients Who Are Not Able to Receive Cisplatin Therapy (SWOG GAP TRIAL)

Phase II Bladder Carcinoma Infiltrating the Muscle of the Bladder Wall trial by SWOG Cancer Research Network. Stop reason: OTHER/UNKNOWN.

inability to accrue sufficient patients

NCT05364645: Testing the Use of Targeted Treatment for RET Positive Advanced Non-small Cell Lung Cancer

Phase II Lung Non-Small Cell Carcinoma trial by SWOG Cancer Research Network. Stop reason: OPERATIONAL.

lack of accrual

NCT03887702: Prophylactic Antiviral Therapy in Patients With Current or Past Hepatitis B Virus Infection Receiving Anti-Cancer Therapy for Solid Tumors

Phase III Hepatitis B Infection trial by SWOG Cancer Research Network. Stop reason: OTHER/UNKNOWN.

inability to accrue

NCT04194528: S1916 Digital Medicine Program for Pain Control in Cancer Patients

Unknown Metastatic Cancer trial by SWOG Cancer Research Network. Stop reason: OPERATIONAL.

Study sponsor withdrew support.

NCT00946712: S0819: Carboplatin and Paclitaxel With or Without Bevacizumab and/or Cetuximab in Treating Patients With Stage IV or Recurrent Non-Small Cell Lung Cancer

Phase III Recurrent Large Cell Lung Carcinoma trial by SWOG Cancer Research Network. Stop reason: EFFICACY/FUTILITY.

terminated at pre-planned futility analysis

NCT02137837: S1222 Trial (Everolimus, Anastrozole and Fulvestrant) in Post-Menopausal Stage IV Breast Cancer

Phase III Breast Cancer trial by SWOG Cancer Research Network. Stop reason: OPERATIONAL.

lack of accrual

NCT04267913: Testing of TAK228 (MLN0128, Sapanisertib) Plus Docetaxel to the Usual Standard of Care for Advanced Squamous Cell Lung Cancer (A Lung-MAP Treatment Trial)

Phase II Lung Squamous Cell Carcinoma trial by SWOG Cancer Research Network. Stop reason: SAFETY.

The pharmaceutical company sold the compound and pulled out.

NCT02926638: Lung-MAP: Rilotumumab and Erlotinib Hydrochloride or Erlotinib Hydrochloride Alone as Second-Line Therapy in Treating Patients With Recurrent Stage IV Squamous Cell Lung Cancer and Positive Biomarker Matches

Phase II MET Positive trial by SWOG Cancer Research Network. Stop reason: OTHER/UNKNOWN.

Drug company decided to terminate all sponsored clinical studies involving rilotumumab.

NCT02134912: S1300: Pemetrexed Disodium With or Without Crizotinib in Treating Patients With Stage IV Non-Small Cell Lung Cancer That Has Progressed After Crizotinib

Phase II Adenocarcinoma of the Lung trial by SWOG Cancer Research Network. Stop reason: OTHER/UNKNOWN.

science has moved forward and there is no intent to complete the study

NCT00088972: S0300, Celecoxib in Preventing Breast Cancer in Premenopausal Women

Phase II Breast Cancer trial by SWOG Cancer Research Network. Stop reason: OPERATIONAL.

Study closed due to poor accrual.

NCT00124579: S0417 Bortezomib, Thalidomide, and Dexamethasone in Treating Patients With Relapsed or Refractory Multiple Myeloma

Phase II Multiple Myeloma trial by SWOG Cancer Research Network. Stop reason: OPERATIONAL.

poor accrual

NCT00058448: S0224, Docetaxel in Treating Patients With Locally Advanced or Metastatic Penile Cancer (TERMINATED)

Phase II Penile Cancer trial by SWOG Cancer Research Network. Stop reason: OPERATIONAL.

Study terminated due to poor patient recruitment.

NCT00005047: 4B951, Combination Chemotherapy in Treating Patients With Bladder Cancer

Phase III Bladder Cancer trial by SWOG Cancer Research Network. Stop reason: EFFICACY/FUTILITY.

Accrual was halted on the basis of the Data and Safety Monitoring Board review of a futility analysis.

NCT00937417: S0716 Vandetanib and Docetaxel in Treating Patients With Advanced Solid Tumors

Phase I Breast Cancer trial by SWOG Cancer Research Network. Stop reason: OPERATIONAL.

Withdrawn because SWOG no longer pursuing this study at this time

NCT00022633: S0028, Gemcitabine and Paclitaxel in Treating Patients With Advanced or Recurrent Cancer of the Urinary Tract

Phase II Bladder Cancer trial by SWOG Cancer Research Network. Stop reason: OPERATIONAL.

Permanently Closed Due to Poor Accrual

NCT00006994: S9908: Glutamine in Treating Mucositis Caused by Radiation Therapy in Patients With Newly Diagnosed Cancer of the Mouth or Throat

Phase III Cancer-related Problem/Condition trial by SWOG Cancer Research Network. Stop reason: OPERATIONAL.

Withdrawn due to drug availability and funding

NCT00109850: S0414 Cetuximab, Combo Chemo, and RT in Locally Advanced Esophageal Cancer

Phase II Esophageal Cancer trial by SWOG Cancer Research Network. Stop reason: OPERATIONAL.

Closed due to poor accrual

NCT00002735: SWOG-9451, Combination Chemo & RT For Patients With Stage III/Stage IV Cancer of the Hypopharynx or Tongue

Phase II Head and Neck Cancer trial by SWOG Cancer Research Network. Stop reason: OPERATIONAL.

Terminated due to poor accrual.

NCT00002999: S9715, Chemotherapy and Radiation Therapy in Treating Patients With Advanced Cancer of the Nasopharynx

Phase II Head and Neck Cancer trial by SWOG Cancer Research Network. Stop reason: OTHER/UNKNOWN.

No stop-reason text available in the compact dataset.

NCT00053014: S0125, Chemotherapy, Total-Body Irradiation, and Peripheral Stem Cell Transplantation in Treating Older Patients With Acute Myeloid Leukemia

Phase II Leukemia trial by SWOG Cancer Research Network. Stop reason: OPERATIONAL.

Poor accrual

NCT01055301: S0833, Bortezomib, Thalidomide, Lenalidomide, Combination Chemotherapy, and Autologous Stem Cell Transplant in Treating Patients With Newly Diagnosed Multiple Myeloma

Phase II Multiple Myeloma trial by SWOG Cancer Research Network. Stop reason: OPERATIONAL.

lack of accrual

NCT00788580: S0718 Pazopanib and Temsirolimus in Treating Patients With Advanced Solid Tumors

Phase I Unspecified Adult Solid Tumor, Protocol Specific trial by SWOG Cancer Research Network. Stop reason: OTHER/UNKNOWN.

Study was discontinued.

NCT00023634: S0114 Vaccine Therapy in Treating Patients With Gastric, Prostate, or Ovarian Cancer

Phase I Brain Tumors trial by SWOG Cancer Research Network. Stop reason: OPERATIONAL.

lack of accrual

NCT00723658: S0629, Observation or Combination Chemotherapy, Bortezomib, Thalidomide, and Rituximab Followed By Two Autologous Peripheral Blood Stem Cell Transplants in Treating Patients With Waldenstrom Macroglobulinemia

Phase II Lymphoma trial by SWOG Cancer Research Network. Stop reason: OPERATIONAL.

lack of accrual

NCT00939328: S0902 Bendamustine and Rituximab in Treating Patients With B-Cell Chronic Lymphocytic Leukemia That Has Not Responded to Previous Treatment

Phase II Leukemia trial by SWOG Cancer Research Network. Stop reason: OTHER/UNKNOWN.

question was no longer committee priority

NCT00005834: S9922 Combination Chemo Plus Filgrastim With or Without Thalidomide in Refractory Multiple Myeloma

Phase III Multiple Myeloma trial by SWOG Cancer Research Network. Stop reason: OPERATIONAL.

poor accrual