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Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins clinical trial failures
Review 106 stopped clinical trials from Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, including disease areas, phases, and classified stop reasons.
This page groups real ClinicalTrials.gov-derived stopped trial records. The strongest added signal is the stop-reason classification: 7 of these records are likely biological failure signals, while the rest may reflect operational, strategic, regulatory, funding, enrollment, or unclear stop reasons.
Dominant stop reasons
- OPERATIONAL
- 64
- OTHER/UNKNOWN
- 35
- SAFETY
- 4
- EFFICACY/FUTILITY
- 3
Notable sponsors
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
- 106
Related phases
- Phase II
- 53
- Phase I
- 39
- Early Phase I
- 7
- Unknown
- 4
- Phase III
- 3
Crawlable stopped-trial records
Open ExploreShowing up to 100 representative records from this slice. Each link opens the trial detail page with source attribution and stop-reason context.
Phase I Acute Myeloid Leukemia trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OTHER/UNKNOWN.
Upon analysis of the first 7 participants accrued, it was determined that this combination treatment is not efficacious as treatment for patients with relapsed or refractory AML
Phase II Mantle Cell Lymphoma trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
The study sponsor withdrew funding early, forcing this study to stop all activity and close pre-maturely.
Phase II Non-Small Cell Lung Cancer trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
low accrual
Phase II Lymphoma trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OTHER/UNKNOWN.
The stopping rule was met and hence the study was closed
Phase II Adenoid Cystic Carcinoma trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OTHER/UNKNOWN.
Sponsor is no longer producing the study drug, so it was not possible to complete the study.
Phase II Resectable Non-Small Cell Lung Cancer trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
no participants enrolled across sites
Phase II Multiple Myeloma trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
loss of funding
Phase I Metastatic Renal Cell Carcinoma trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
funding withdrawn
Phase I Systemic Sclerosis trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
This study was closed due to low accrual
Phase II Prostate Cancer trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
The study was terminated by the IRB due to low accrual,
Phase II High Grade Glioma trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OTHER/UNKNOWN.
NCI decided to terminate ABTC Consortium due to NCI moving in different direction for Brain Cancer
Phase II Breast Cancer trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
The Principal Investigator left Johns Hopkins
Phase II Prostate Cancer trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OTHER/UNKNOWN.
Principal Investigator has decided not to activate this trial.
Phase I B Cells-Tumors trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OTHER/UNKNOWN.
Safety endpointreached
Phase I Prostate Cancer trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
lack of accrual
Early Phase I Brain and Central Nervous System Tumors trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OTHER/UNKNOWN.
NCI decided to terminate ABTC Consortium due to NCI moving in different direction for Brain Cancer - official close date is 10/31/23
Unknown Pancreatic Cancer trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OTHER/UNKNOWN.
Ultrasound vendor cannot support the study
Phase I Non-small Cell Lung Cancer (NSCLC) trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
The study is terminated because the PI left the institution.
Phase I Metastatic Prostate Cancer trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
The Principal Investigator decided to terminate the study because the PI left Hopkins.
Phase II Neuroendocrine Tumors trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
Loss of funding
Phase I Prostate Cancer trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OTHER/UNKNOWN.
Due to changing prostate cancer standard of care, the research question became obsolete as the target population for the study no longer existed. The study is deemed not clinically relevant.
Phase I High Grade Glioma trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OTHER/UNKNOWN.
Terminated \[NCI decided to terminate ABTC Consortium due to NCI moving in different direction for Brain Cancer\]
Phase I Covid19 trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
PI Decision to close/stop the study due to no new accrual.
Phase I Lymphopenia trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OTHER/UNKNOWN.
Terminated \[NCI decided to terminate ABTC Consortium due to NCI moving in different direction for Brain Cancer\]
Phase II Hormone-Resistant Prostate Cancer trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: SAFETY.
insufficient clinical response per DSMB
Phase III Adenocarcinoma of the Prostate trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: EFFICACY/FUTILITY.
The study was terminated by DSMB due to futility.
Phase I Pancreatic Cancer Metastatic trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
Study never started
Phase I Lymphoproliferative Disorder trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
Loss of funding
Early Phase I Myelodysplastic Syndromes trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
Loss of funding
Phase I Recurrent Human Papillomavirus Type 16 Associated Cancer trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OTHER/UNKNOWN.
The study team decided not to move forward with the study.
Phase II Metastatic Colorectal Adenocarcinoma trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: SAFETY.
No stop-reason text available in the compact dataset.
Phase II HPV Positive Oropharyngeal Squamous Cell Carcinoma trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
Sponsor withdrew funding
Phase II Prostate Adenocarcinoma trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
accrual on hold
Phase II Prostate Cancer trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
Lack of funding
Phase I Breast Cancer trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
Lock of funding
Early Phase I Medulloblastoma trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OTHER/UNKNOWN.
Participant relapses led to abrupt stop of study.
Phase II Prostate Cancer trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
Low accrual due to COVID-19 pandemic.
Phase I Solid Tumor trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
Deprioritization of drug in this patient population
Phase I Primary Peritoneal Carcinoma trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OTHER/UNKNOWN.
Withdrawal of sponsor support
Phase II Metastatic Melanoma trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
Unable to enroll patients in this study
Phase II COVID-19 trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OTHER/UNKNOWN.
Limited resources.
Phase II Patients With Leptomeningeal Disease trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
Low Accrual
Phase I Glioblastoma trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
Funding/material support withdrawn
Phase II Resectable Biliary Tract Cancer trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OTHER/UNKNOWN.
No subjects were enrolled
Phase I Acute Myeloid Leukemia trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OTHER/UNKNOWN.
The manufacturer discontinued necessary reagents.
Phase I Prostate Cancer trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
Low accrual
Phase I Pancreatic Adenocarcinoma trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OTHER/UNKNOWN.
We need to make significant adjustments to proposed drug and its delivery method
Phase I Pancreatic Ductal Adenocarcinoma trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OTHER/UNKNOWN.
Study was terminated due to cease in manufacturing of study drug.
Phase II Metastatic Osteosarcoma trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
Low accrual and loss of funding
Phase I Lupus Erythematosus trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OTHER/UNKNOWN.
Study was unable to accrue subjects
Phase II Solid Tumors Induced by Prior Radiation Exposure trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
Poor accrual
Phase II Transplant-Related Cancer trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
Low accrual and loss of funding.
Phase I Acute Myeloid Leukemia (AML) trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
Study drug supply expired and could not be renewed.
Phase II Sickle Cell Disease trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
Initiation of CMS BMT study for sickle-cell disease operating under NCT01166009 made further accrual to this study impossible.
Unknown Prostate Cancer trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: SAFETY.
The study was stopped due to an unanticipated serious adverse event.
Phase II Breast Cancer trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
low accrual
Phase II Refractory Nasopharyngeal Carcinoma trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
Low accrual.
Phase II Lung Cancer trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
Low accrual
Phase II Recurrent Non Small Cell Lung Cancer trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
Low accrual.
Phase II Esophageal Cancer trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OTHER/UNKNOWN.
Study stopped due to early stopping rule
Phase I Prostate Cancer trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
Low accrual
Early Phase I Pancreatic Cancer trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
Loss of funding
Early Phase I Cancer trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
The study was terminated per PI decision.
Phase II Multiple Myeloma trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OTHER/UNKNOWN.
MEDI-551 removed from oncology by pharmaceutical company due to change in research target.
Phase I Head and Neck Cancer trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
Low accrual
Phase II Carcinoma, Non-Small-Cell Lung trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
Low enrollment
Phase II Multiple Myeloma trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OTHER/UNKNOWN.
early stopping rule
Phase II Head and Neck Cancer trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OTHER/UNKNOWN.
Closed due to early stopping rule
Phase II Esophageal Cancer trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
Closed due to early stopping rule-Low accrual
Phase II Retinoblastoma trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OTHER/UNKNOWN.
IAC is now recognized as part of standard of care treatment options in the US.
Phase I Head and Neck Cancer trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
Study Funding Terminated
Early Phase I Multiple Myeloma and Plasma Cell Neoplasm trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
Low accrual
Phase II Pancreatic Cancer trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OTHER/UNKNOWN.
Because there was no longer an active laboratory component to this study.
Phase I Lymphoma trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
Low accrual
Phase II Non-small Cell Lung Cancer Metastatic trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
Low Accrual
Phase II Myelodysplastic Syndrome trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: EFFICACY/FUTILITY.
Lack of efficacy
Phase II Prostate Cancer trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
The study was terminated per the PI decision.
Phase II Non-Hodgkin's Lymphoma trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
Low accrual
Phase II Lymphoma trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
slow accrual/lack of resources/low priority due to combining 2 consortia
Unknown Brain and Central Nervous System Tumors trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
Study terminated due to low accrual.
Phase II Lymphoma trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
Funding was unavailable to complete the study as originally planned.
Phase I Leukemia trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OTHER/UNKNOWN.
Expiration of study supply
Phase I Leukemia trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
Poor accrual
Phase II Acute Myeloid Leukemia trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
Low accrual
Phase I Squamous Cell Carcinoma of the Head and Neck trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
Slow accrual and high levels of toxicity lead to early termination.
Phase II Brain and Central Nervous System Tumors trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OTHER/UNKNOWN.
prematurely discontinued after results of the EORTC phase-3 study defined the SOC for newly diagnosed GMB pts as RT plus concomitant and adjuvant TMZ
Phase I Head and Neck Cancer trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: SAFETY.
Toxicity
Phase I Prostate Cancer trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
Study was Terminated by PI due to low accrual
Unknown Hormone-Resistant Prostate Cancer trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
The study is terminated due to lower enrollment
Phase II Pancreatic Cancer trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: EFFICACY/FUTILITY.
All consented subjects tested negative for the BRCA2 mutation, therefore, did not meet criteria to start the study, resulting in withdrawal by PI
Phase II Brain and Central Nervous System Tumors trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
Terminated - due to low accrual
Phase II Fibrolamellar Hepatocellular Carcinoma trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OTHER/UNKNOWN.
This study was withdrawn due to lack of necessary resources from the liver transplant surgical group.
Phase III Cancer trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
Low accrual
Phase I Lymphoma trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
Poor accrual
Phase I Myelodysplastic Syndrome trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
Lack of accrual
Phase II Detectable Prostate Nodules trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OPERATIONAL.
Due to lack of accrual for this study. PI decided to close the study.
Phase I Astrocytoma trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OTHER/UNKNOWN.
PI leaving institution
Phase III Melanoma trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OTHER/UNKNOWN.
no patients were enrolled
Phase I Newly Diagnosed Melanoma Metastases in the Brain and Spine trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OTHER/UNKNOWN.
Local IRB required us to submit amendment as a separate study.
Phase I Tumors trial by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. Stop reason: OTHER/UNKNOWN.
Design Problem