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Northwestern University clinical trial failures
Review 129 stopped clinical trials from Northwestern University, including disease areas, phases, and classified stop reasons.
This page groups real ClinicalTrials.gov-derived stopped trial records. The strongest added signal is the stop-reason classification: 10 of these records are likely biological failure signals, while the rest may reflect operational, strategic, regulatory, funding, enrollment, or unclear stop reasons.
Dominant stop reasons
- OPERATIONAL
- 72
- OTHER/UNKNOWN
- 47
- SAFETY
- 6
- EFFICACY/FUTILITY
- 4
Notable sponsors
- Northwestern University
- 129
Related phases
- Phase I
- 32
- Phase II
- 30
- Phase IV
- 30
- Unknown
- 24
- Phase III
- 9
Crawlable stopped-trial records
Open ExploreShowing up to 100 representative records from this slice. Each link opens the trial detail page with source attribution and stop-reason context.
Phase I Glioma, Malignant trial by Northwestern University. Stop reason: SAFETY.
Safety issues
Phase II Stage IV Colorectal Cancer Positive for BRAF V600E Mutation trial by Northwestern University. Stop reason: OPERATIONAL.
The study was closed due to accrual.
Phase I Acute Myeloid Leukemia trial by Northwestern University. Stop reason: OTHER/UNKNOWN.
Premature withdrawal of investigational product per study sponsor.
Phase I Recurrent Acute Myeloid Leukemia trial by Northwestern University. Stop reason: OPERATIONAL.
Low accrual
Phase II Low Back Pain trial by Northwestern University. Stop reason: OPERATIONAL.
Insufficient funding to complete the study
Phase IV Distributive Shock trial by Northwestern University. Stop reason: OPERATIONAL.
Enrollment Challenges
Phase II Prostate Cancer trial by Northwestern University. Stop reason: OPERATIONAL.
PI left institution
Phase II Prostate Carcinoma trial by Northwestern University. Stop reason: OTHER/UNKNOWN.
Study aborted
Phase III Schizophrenia trial by Northwestern University. Stop reason: OPERATIONAL.
unable to secure additional funding
Phase II Hot Flashes trial by Northwestern University. Stop reason: OTHER/UNKNOWN.
Audit panel terminated IRB approval and closed the study study.
Phase IV Pain trial by Northwestern University. Stop reason: OPERATIONAL.
Lack of continued funding
Unknown Upper Back Fat trial by Northwestern University. Stop reason: OPERATIONAL.
Unable to enroll participants for analysis.
Phase I Covid19 trial by Northwestern University. Stop reason: OPERATIONAL.
Enrollment challenges; new batch of drug is being manufactured and there may be additional impetus to reactivate after the analogous Phase 2 study in Japan is completed and those results are made available
Phase IV Pain trial by Northwestern University. Stop reason: OTHER/UNKNOWN.
Principal investigator is leaving the university.
Phase II Breast Cancer trial by Northwestern University. Stop reason: OTHER/UNKNOWN.
Medical student graduated and stopped project
Phase IV Neuroma trial by Northwestern University. Stop reason: OTHER/UNKNOWN.
The attendings who were to participate did not want to alter their standard neuroma treatment of neurotomy and TMR, as opposed to dissecting the end of all neuromas before neurotomy. No patients were enrolled in the study.
Phase I Pregnancy trial by Northwestern University. Stop reason: OTHER/UNKNOWN.
transfer of PI to new organization
Phase III Pain, Postoperative trial by Northwestern University. Stop reason: OTHER/UNKNOWN.
Stopped study due to pharmacy issues before treating patients
Unknown Pregnancy trial by Northwestern University. Stop reason: OPERATIONAL.
The study was terminated due to low enrollment due to competing studies and the PI has now left Northwestern.
Phase I Breast Carcinoma trial by Northwestern University. Stop reason: OTHER/UNKNOWN.
Study terminated by the sponsor
Unknown Premature Rupture of Membrane trial by Northwestern University. Stop reason: SAFETY.
The IRB identified too many safety issues and the study did not move ahead.
Phase II Acute Pain trial by Northwestern University. Stop reason: OPERATIONAL.
Study was not started, therefore recruitment did not happen
Phase II Recurrent Transformed Chronic Lymphocytic Leukemia trial by Northwestern University. Stop reason: OPERATIONAL.
Funding
Early Phase I Hepatocellular Carcinoma trial by Northwestern University. Stop reason: OPERATIONAL.
Lack of funding
Unknown REM Behavior Disorder trial by Northwestern University. Stop reason: OPERATIONAL.
Low subject recruitment and enrollment.
Unknown Chest Pain trial by Northwestern University. Stop reason: OTHER/UNKNOWN.
Terminated due to departure of PI from institution.
Phase I Adult Glioblastoma trial by Northwestern University. Stop reason: OTHER/UNKNOWN.
The protocol was amendment to be stopped after phase I (phase 2 removed from protocol)
Phase IV High Blood Pressure trial by Northwestern University. Stop reason: EFFICACY/FUTILITY.
Screened participants did not meet inclusion criteria prior to study completion date
Phase II Recurrent Angioimmunoblastic T-Cell Lymphoma trial by Northwestern University. Stop reason: OPERATIONAL.
Study inactivated due to zero accruals
Phase IV Fibroids trial by Northwestern University. Stop reason: OPERATIONAL.
The study was prematurely closed due to low enrollment rates.
Phase II Acneiform Rash trial by Northwestern University. Stop reason: OPERATIONAL.
Low enrollment accrual
Phase IV Chronic Prostatitis With Chronic Pelvic Pain Syndrome trial by Northwestern University. Stop reason: OPERATIONAL.
The study was closed due to recruitment limitations
Phase II Psychiatric Illness trial by Northwestern University. Stop reason: OTHER/UNKNOWN.
Study sponsor was acquired by another company.
Phase IV Depressive Disorder trial by Northwestern University. Stop reason: OPERATIONAL.
No enrollment
Phase III Hip Pain Chronic trial by Northwestern University. Stop reason: OPERATIONAL.
Study was never started. Did not receive funding.
Phase IV Prostate Cancer trial by Northwestern University. Stop reason: OPERATIONAL.
Enrollment issues
Phase I Anatomic Stage IV Breast Cancer AJCC v8 trial by Northwestern University. Stop reason: OPERATIONAL.
funding issues and pharmacy preparation for the drug
Phase II Pancreatic Adenocarcinoma trial by Northwestern University. Stop reason: OPERATIONAL.
The total accrual goal of 34 patients was not met. Stage 1 of the study did not meet the interim analysis criteria to move onto Stage 2 of the Simon 2 stage design.
Phase IV Postoperative Pain trial by Northwestern University. Stop reason: OPERATIONAL.
Low Enrollment
Phase I Aggressive Non-Hodgkin Lymphoma trial by Northwestern University. Stop reason: OPERATIONAL.
Protocol being amended for stats/accrual changes as per PI
Phase II Hot Flashes trial by Northwestern University. Stop reason: OPERATIONAL.
Study stopped due to inadequate enrollment.
Phase IV Anesthesia trial by Northwestern University. Stop reason: OPERATIONAL.
Insufficient enrollment
Phase IV Headache trial by Northwestern University. Stop reason: OPERATIONAL.
lack of recruitment
Unknown Pregnancy trial by Northwestern University. Stop reason: OPERATIONAL.
PI terminated study with no subjects enrolled.
Phase IV HF - Heart Failure trial by Northwestern University. Stop reason: OPERATIONAL.
Enrollment and funding challenges
Phase IV Pain, Postoperative trial by Northwestern University. Stop reason: OTHER/UNKNOWN.
Change in institutional policy. Change in resources available.
Phase IV Pain, Chronic trial by Northwestern University. Stop reason: OPERATIONAL.
Covid restrictions on recruitment
Phase IV Hyponatremia trial by Northwestern University. Stop reason: OPERATIONAL.
Enrollment below goal.
Unknown Pregnancy trial by Northwestern University. Stop reason: OPERATIONAL.
Study concluded prematurely prior to meeting intended goal recruitment.
Phase II Androgenetic Alopecia trial by Northwestern University. Stop reason: OTHER/UNKNOWN.
Did not want to enroll and proceed with this study concept.
Unknown Wound Healing trial by Northwestern University. Stop reason: OPERATIONAL.
Participants never enrolled, study never started.
Phase IV Enhanced Recovery Pathway trial by Northwestern University. Stop reason: OPERATIONAL.
Investigator left organization before study initiated.
Early Phase I Actinic Keratosis trial by Northwestern University. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase I Acne Scars trial by Northwestern University. Stop reason: OTHER/UNKNOWN.
Company stopped making product for cosmetic use. All consented subjects withdrew before any study interventions were performed.
Unknown Gingival Exposure trial by Northwestern University. Stop reason: OPERATIONAL.
The study never started.
Phase I Adult Grade III Lymphomatoid Granulomatosis trial by Northwestern University. Stop reason: OPERATIONAL.
Lack of funding
Phase II Herpes Zoster Keratitis trial by Northwestern University. Stop reason: OPERATIONAL.
There were difficulties meeting the enrollment goal within stipulated time frames.
Phase I Stiff-Person Syndrome trial by Northwestern University. Stop reason: OTHER/UNKNOWN.
Could not predict who would respond, relapse or go into remission
Phase III Multiple Sclerosis, Relapsing-Remitting trial by Northwestern University. Stop reason: OTHER/UNKNOWN.
PI Sabbatical
Phase III Osteoporosis trial by Northwestern University. Stop reason: OTHER/UNKNOWN.
Closed by the research committee
Phase II Brain Concussion trial by Northwestern University. Stop reason: OTHER/UNKNOWN.
Lack of study participants.
Phase IV Hyperglycemia Steroid-induced trial by Northwestern University. Stop reason: OPERATIONAL.
Unable to recruit sufficient number of patients
Phase II Systemic Sclerosis trial by Northwestern University. Stop reason: OTHER/UNKNOWN.
PI Sabbatical
Phase III Scleroderma, Systemic trial by Northwestern University. Stop reason: OTHER/UNKNOWN.
Developed a better regimen: DIAD. Cast. 2018 NCT03593902
Phase II HER2/Neu Negative trial by Northwestern University. Stop reason: OPERATIONAL.
Slow accrual
Phase II Breast Carcinoma Metastatic in the Brain trial by Northwestern University. Stop reason: OPERATIONAL.
Slow accrual
Phase II Bronchiolitis Obliterans trial by Northwestern University. Stop reason: OPERATIONAL.
Study was closed due to low accrual before the accrual goal was reached
Phase IV Chronic Sinusitis trial by Northwestern University. Stop reason: OTHER/UNKNOWN.
Realized there was a design flaw.
Phase II Adult Anaplastic Astrocytoma trial by Northwestern University. Stop reason: OPERATIONAL.
Slow accrual to some cohorts
Phase I B Acute Lymphoblastic Leukemia With t(9 trial by Northwestern University. Stop reason: OPERATIONAL.
Due to funding and accrual issues
Unknown Pain trial by Northwestern University. Stop reason: OTHER/UNKNOWN.
Could not obtain dedicated ultrasound device.
Phase II Neuromyelitis Optica trial by Northwestern University. Stop reason: OTHER/UNKNOWN.
Discontinued by Investigator
Phase III Parkinson's Disease trial by Northwestern University. Stop reason: OPERATIONAL.
Due to lack of recruitment
Phase II Crohn's Disease trial by Northwestern University. Stop reason: OTHER/UNKNOWN.
Discontinued by Investigator
Phase IV Postpartum Depression trial by Northwestern University. Stop reason: OPERATIONAL.
Recruitment Issues
Phase I Lymphoma trial by Northwestern University. Stop reason: OPERATIONAL.
Study was closed permanently before the accrual goal was met due to slow accrual
Phase I Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma trial by Northwestern University. Stop reason: OPERATIONAL.
Slow accrual
Phase I Lymphoma trial by Northwestern University. Stop reason: OPERATIONAL.
This was planned as a phase I/II study originally, but due to a lack of funding, the phase II portion was never conducted.
Phase I Polycythemia Vera, Post-Polycythemic Myelofibrosis Phase trial by Northwestern University. Stop reason: OPERATIONAL.
PI decided to withdraw the study after it opened for enrollment but before any patients were enrolled
Phase I Non-Hodgkin's Lymphoma (NHL) trial by Northwestern University. Stop reason: OPERATIONAL.
Due to lack of funding, phase II of study was not completed.
Phase I Lymphoma trial by Northwestern University. Stop reason: SAFETY.
Closed per Data Monitoring Committee due to lack of efficacy
Unknown Hereditary Clear Cell Renal Cell Carcinoma trial by Northwestern University. Stop reason: OPERATIONAL.
Low Accrual
Phase II Metastatic Carcinoma in the Adrenal Cortex trial by Northwestern University. Stop reason: EFFICACY/FUTILITY.
Study did not meet first stage requirements of interim analysis
Phase IV Kidney Transplant trial by Northwestern University. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase I Adult Acute Megakaryoblastic Leukemia (M7) trial by Northwestern University. Stop reason: OPERATIONAL.
Slow accrual
Unknown Lymphoma trial by Northwestern University. Stop reason: OPERATIONAL.
Closed early due to poor accrual.
Phase II Breast Carcinoma Metastatic in the Bone trial by Northwestern University. Stop reason: OPERATIONAL.
Low accrual
Early Phase I Morphea trial by Northwestern University. Stop reason: OPERATIONAL.
Accrual incomplete/Investigator left institution
Phase I Myasthenia Gravis trial by Northwestern University. Stop reason: OPERATIONAL.
No participants enrolled for more than two years. No plan to continue study.
Phase I Sarcoidosis trial by Northwestern University. Stop reason: OPERATIONAL.
No plan to continue enrollment
Phase IV Quality of Recovery trial by Northwestern University. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase I MYOPATHY trial by Northwestern University. Stop reason: OTHER/UNKNOWN.
high relapse rate
Phase I Crohn's Disease trial by Northwestern University. Stop reason: SAFETY.
No participant enrolled more than two years. No plan to continue study.
Phase I Vasculitis trial by Northwestern University. Stop reason: OTHER/UNKNOWN.
No participant enrolled over five years. No plan to continue the study.
Phase I Rheumatoid Arthritis trial by Northwestern University. Stop reason: SAFETY.
No participant enrolled for three years. No plan to continue study.
Phase IV Chronic Rhinosinusitis Without Nasal Polyps trial by Northwestern University. Stop reason: OTHER/UNKNOWN.
participants are no longer receiving intervention due to clinical logistics
Phase II Stage III Diffuse Large B-Cell Lymphoma trial by Northwestern University. Stop reason: OTHER/UNKNOWN.
sponsor decided to discontinue development of the study drug.
Unknown Diaper Rash trial by Northwestern University. Stop reason: OTHER/UNKNOWN.
Principal Investigator and sponsor agreed to termination.
Unknown Pregnancy trial by Northwestern University. Stop reason: OTHER/UNKNOWN.
planned surgical procedures decreased
Phase IV Rupture of Anterior Cruciate Ligament trial by Northwestern University. Stop reason: OPERATIONAL.
The study was terminated due to lack of subject recruitment