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Merck Sharp & Dohme LLC clinical trial failures
Review 281 stopped clinical trials from Merck Sharp & Dohme LLC, including disease areas, phases, and classified stop reasons.
This page groups real ClinicalTrials.gov-derived stopped trial records. The strongest added signal is the stop-reason classification: 16 of these records are likely biological failure signals, while the rest may reflect operational, strategic, regulatory, funding, enrollment, or unclear stop reasons.
Dominant stop reasons
- OTHER/UNKNOWN
- 164
- OPERATIONAL
- 99
- EFFICACY/FUTILITY
- 8
- SAFETY
- 8
- REGULATORY
- 2
Notable sponsors
- Merck Sharp & Dohme LLC
- 281
Related phases
- Phase II
- 106
- Phase I
- 81
- Phase III
- 76
- Phase IV
- 18
Crawlable stopped-trial records
Open ExploreShowing up to 100 representative records from this slice. Each link opens the trial detail page with source attribution and stop-reason context.
Phase II Alzheimer Disease trial by Merck Sharp & Dohme LLC. Stop reason: OTHER/UNKNOWN.
Termination Notes: Business reason
Phase II Carcinoma, Squamous Cell trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
Business reasons
Phase III HIV Preexposure Prophylaxis trial by Merck Sharp & Dohme LLC. Stop reason: SAFETY.
Voluntarily terminated due to benefit/risk assessment.
Phase II Treatment Resistant Depression trial by Merck Sharp & Dohme LLC. Stop reason: SAFETY.
Voluntarily terminated due to benefit/risk assessment
Phase I Narcolepsy trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
Terminated for business reasons
Phase II Non-segmental Vitiligo trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
Business Reasons
Phase II Early Triple Negative Breast Cancer trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
Since patients were not recruited yet, we would mark this as a Withdrawn status per the NIH definition of that status. Study halted prematurely, prior to enrollment of first participant.
Phase III HIV-I trial by Merck Sharp & Dohme LLC. Stop reason: SAFETY.
Voluntarily terminated due to benefit/risk assessment
Phase III Non-Small Cell Lung Cancer trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
Terminated for business reasons
Phase II Systemic Lupus Erythematosus trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
Business Reasons
Phase I Solid Tumor trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
Business Reasons
Phase I HIV-1 Infection trial by Merck Sharp & Dohme LLC. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase II Nonalcoholic Steatohepatitis trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
Business reasons
Phase I Relapsed or Refractory Acute Myeloid Leukemia trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
Business Reasons
Phase I Coronavirus Disease 2019 (COVID-19) trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
Business reasons
Phase I Alzheimer's Disease trial by Merck Sharp & Dohme LLC. Stop reason: OTHER/UNKNOWN.
Development program discontinuation
Phase I Neoplasm Metastasis trial by Merck Sharp & Dohme LLC. Stop reason: OTHER/UNKNOWN.
development program discontinuation
Phase III HPV Infections trial by Merck Sharp & Dohme LLC. Stop reason: REGULATORY.
Following the direction of the local (India) health authority, data specified in the protocol were not collected and study was cancelled.
Phase I Neoplasms trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
Business Reasons
Phase II Alzheimer's Disease trial by Merck Sharp & Dohme LLC. Stop reason: SAFETY.
Voluntarily terminated due to benefit/risk assessment
Phase I Healthy trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
Business Reasons
Phase I Neoplasms trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
business reasons.
Phase I Neoplasm Metastasis trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
Business Reasons
Phase I Advanced Solid Tumors trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
Business Reasons
Phase I Advanced/Metastatic Solid Tumors trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
Business Reasons
Phase I Neoplasm Metastasis trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
Business Reasons
Phase II Anemia trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
Persistent low enrollment made study continuation no longer feasible
Phase II Advanced/Metastatic Melanoma trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
Business Reasons
Phase III Prostatic Neoplasms trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
The data did not support study endpoints
Phase III Postmenopausal Osteoporosis trial by Merck Sharp & Dohme LLC. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase I Advanced Solid Tumors trial by Merck Sharp & Dohme LLC. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase II Hepatitis trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
No stop-reason text available in the compact dataset.
Phase II Hepatitis C, Chronic trial by Merck Sharp & Dohme LLC. Stop reason: OTHER/UNKNOWN.
Preliminary results of MK-5172 PN003 (NCT01353911) suggested a possible dose relationship to elevated transaminase levels in treatment with grazoprevir.
Phase III Primary Hypercholesterolemia trial by Merck Sharp & Dohme LLC. Stop reason: EFFICACY/FUTILITY.
In HPS2-THRIVE, MK-0524A did not meet the primary efficacy objective and there was a significant increase in incidence of some types of non-fatal SAEs
Phase II Solid Tumors trial by Merck Sharp & Dohme LLC. Stop reason: OTHER/UNKNOWN.
Isotope needed to conduct RBC/PV analysis (primary endpoint) no longer available from manufacturer. No alternatives available for use.
Phase II Human Immunodeficiency Virus trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
Business Reasons
Phase I Solid Tumors trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
The study has been terminated due to business reasons.
Phase I Cervical Cancer trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
The sponsor permanently suspended new enrollment into the trial and discontinued the study; which was not related to any concerns over product safety.
Phase II Chemotherapy Induced Anemia trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
administrative reasons (slow patient enrollment)
Phase III Gastric Neoplasms trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
Business Reasons
Phase I HIV-1 trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
Business Reasons
Phase II Coronavirus Disease (COVID-19) trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
Business reasons
Phase I Renal Impairment trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
Business reasons
Phase II Human Immunodeficiency Virus (HIV) Infections trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
Business Reasons
Phase I AML Including AML de Novo and AML Secondary to MDS trial by Merck Sharp & Dohme LLC. Stop reason: OTHER/UNKNOWN.
This study was terminated due to limited efficacy and not due to safety reasons
Phase I Advanced Solid Tumors trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
Business Reasons
Phase I Coronavirus Disease (COVID-19) trial by Merck Sharp & Dohme LLC. Stop reason: OTHER/UNKNOWN.
The study was terminated based on an interim assessment of immunogenicity.
Phase I Coronavirus Disease (COVID-19) trial by Merck Sharp & Dohme LLC. Stop reason: OTHER/UNKNOWN.
The study was terminated based on an interim assessment of immunogenicity
Phase III Stomach Neoplasms trial by Merck Sharp & Dohme LLC. Stop reason: OTHER/UNKNOWN.
Withdrawn due to protocol amendment
Phase III Multiple Myeloma trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
The study was terminated early due to business reasons
Phase II Rheumatoid Arthritis trial by Merck Sharp & Dohme LLC. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase III Multiple Myeloma trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
The study was terminated early due to business reasons
Phase I Multiple Myeloma trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
Business Reasons
Phase I Neoplasms trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
Business Reasons
Phase I rrCLL trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
Business Reasons
Phase II Hepatitis C trial by Merck Sharp & Dohme LLC. Stop reason: OTHER/UNKNOWN.
The study was terminated based on review of Phase 2 efficacy data
Phase III Sleep Initiation and Maintenance Disorders trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
This trial was stopped prematurely due to the Sponsor's decision not to continue the development of esmertazapine for this indication.
Phase III Chronic Hepatitis C trial by Merck Sharp & Dohme LLC. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase I NUT Midline Carcinoma (NMC) trial by Merck Sharp & Dohme LLC. Stop reason: OTHER/UNKNOWN.
This study was terminated due to limited efficacy and not due to safety reasons.
Phase I Renal Cell Cancer trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
Terminated early due to low enrollment
Phase II Advanced Melanoma trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
Lack of Accrual
Phase II Rectal Neoplasms trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
This trial was halted prematurely for business reasons and low enrollment.
Phase I Tumor, Solid trial by Merck Sharp & Dohme LLC. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase III Esophageal Neoplasms trial by Merck Sharp & Dohme LLC. Stop reason: OTHER/UNKNOWN.
Withdrawn due to protocol amendment
Phase II Acute Cough trial by Merck Sharp & Dohme LLC. Stop reason: OTHER/UNKNOWN.
The data did not support study endpoints for acute cough, based on an interim efficacy analysis; not due to safety concerns.
Phase II Candidiasis, Invasive trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
Operational feasibility with low recruitment due to changing epidemiology of disease
Phase I Multiple Myeloma trial by Merck Sharp & Dohme LLC. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase I Hepatic Insufficiency trial by Merck Sharp & Dohme LLC. Stop reason: OTHER/UNKNOWN.
Business and program changes
Phase I Advanced Solid Tumor trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
Enrollment prematurely discontinued due to program prioritization \& not due to any safety concerns.
Phase IV Adenomatous Polyposis Coli trial by Merck Sharp & Dohme LLC. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase III HIV Infections trial by Merck Sharp & Dohme LLC. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase III Osteoporosis trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
Study halted prematurely due to low enrollment.
Phase II Chronic Myelogenous Leukemia trial by Merck Sharp & Dohme LLC. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase I Advanced Solid Tumors trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
Group B not started for business reasons.
Phase II Melanoma trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
This study was closed to enrollment prematurely due to sub-optimal accrual.
Phase II Hepatitis C, Chronic trial by Merck Sharp & Dohme LLC. Stop reason: OTHER/UNKNOWN.
The study was terminated based on review of Phase 2 efficacy data
Phase I Neoplasm trial by Merck Sharp & Dohme LLC. Stop reason: OTHER/UNKNOWN.
The data did not support study endpoints
Phase III Amnestic Mild Cognitive Impairment trial by Merck Sharp & Dohme LLC. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase II HIV Infections trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
This study was terminated early due to poor recruitment.
Phase II Rheumatoid Arthritis (RA) trial by Merck Sharp & Dohme LLC. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase II Multiple Myeloma trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
Business Reasons
Phase I Follicular Lymphoma trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
The study was terminated for business reasons.
Phase III Chemotherapy-induced Nausea and Vomiting trial by Merck Sharp & Dohme LLC. Stop reason: OTHER/UNKNOWN.
Further data are no longer required to support an application for use in pediatric patients. The decision to terminate was not based on any new safety findings
Phase I Atopic Dermatitis trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
The study was prematurely stopped due to business reasons.
Phase I Solid Tumors trial by Merck Sharp & Dohme LLC. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase II Advanced Cancers trial by Merck Sharp & Dohme LLC. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase III Primary Hypercholesterolemia trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
Business Reasons
Phase I Neoplasms, Advanced trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
The study was terminated early due to business reasons.
Phase II COPD trial by Merck Sharp & Dohme LLC. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase II Chronic Obstructive Pulmonary Disease trial by Merck Sharp & Dohme LLC. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase I Overactive Bladder trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
This study was terminated early due to insufficient recruitment.
Phase II Akathisia, Drug-Induced trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
The study was terminated after 9 participants completed due to lack of enrollment for 6 months.
Phase I Alzheimer's Disease trial by Merck Sharp & Dohme LLC. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase III Parkinson Disease trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
Termininated for business reasons
Phase II Akathisia, Drug-Induced trial by Merck Sharp & Dohme LLC. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase II Major Depressive Disorder, Recurrent trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
Low Enrollment
Phase III Parkinson Disease trial by Merck Sharp & Dohme LLC. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase III Type 2 Diabetes Mellitus trial by Merck Sharp & Dohme LLC. Stop reason: OPERATIONAL.
The study was terminated for business reasons and not due to any safety or efficacy concerns related to omarigliptin
Phase I Pulmonary Hypertension trial by Merck Sharp & Dohme LLC. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase IV Hepatitis C, Chronic trial by Merck Sharp & Dohme LLC. Stop reason: OTHER/UNKNOWN.
The trial was terminated due to change in new standard of therapy during the study period.