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Massachusetts General Hospital clinical trial failures
Review 167 stopped clinical trials from Massachusetts General Hospital, including disease areas, phases, and classified stop reasons.
This page groups real ClinicalTrials.gov-derived stopped trial records. The strongest added signal is the stop-reason classification: 10 of these records are likely biological failure signals, while the rest may reflect operational, strategic, regulatory, funding, enrollment, or unclear stop reasons.
Dominant stop reasons
- OPERATIONAL
- 116
- OTHER/UNKNOWN
- 40
- EFFICACY/FUTILITY
- 6
- SAFETY
- 4
- REGULATORY
- 1
Notable sponsors
- Massachusetts General Hospital
- 167
Related phases
- Phase II
- 56
- Phase IV
- 45
- Phase I
- 31
- Unknown
- 20
- Phase III
- 10
Crawlable stopped-trial records
Open ExploreShowing up to 100 representative records from this slice. Each link opens the trial detail page with source attribution and stop-reason context.
Phase IV PANDAS trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
Low recruitment
Phase II Prostate Cancer trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
Slow accrual
Unknown Chronic Pain trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
End of NIH funding
Phase IV Chronic Pain trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
End of NIH funding
Phase II Coronavirus Infections trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
COVID wave passed
Phase II Coronavirus Infections trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
COVID wave passed and we closed the study prematurely
Phase II Lymphoma trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
Umbralisib development terminated; closed to accrual 8/29/2022
Phase II Myelodysplastic Syndromes trial by Massachusetts General Hospital. Stop reason: OTHER/UNKNOWN.
The trial closed early due to changes in support for the study drug.
Phase III Autism trial by Massachusetts General Hospital. Stop reason: OTHER/UNKNOWN.
requested by the IRB
Phase IV Post-operative Pain trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
lack of funding
Phase IV Opioid-use Disorder trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
lack of funding
Phase II Adenocarcinoma Stomach trial by Massachusetts General Hospital. Stop reason: OTHER/UNKNOWN.
The pharmaceutical company is not moving forward with this intervention due to lack of efficacy.
Phase II Endothelial Dysfunction trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
Lack of funding
Phase I Pneumonia trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
Lack of funding
Phase II Cardiovascular Diseases trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
Lack of funding
Phase II Major Depressive Disorder trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
we were not able to get the study drug due to covid
Phase II Sleep Disorder trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
An interim analysis indicated that we would need to enroll more subjects than our initial enrollment target, in order to demonstrate a significant treatment effect. Due to these results, we have decided to terminate this protocol.
Phase II Biliary Tract Cancer trial by Massachusetts General Hospital. Stop reason: EFFICACY/FUTILITY.
Based on a Simon 2-stage design, this study did not meet response criteria to proceed to stage 2.
Phase II Solid Tumor trial by Massachusetts General Hospital. Stop reason: EFFICACY/FUTILITY.
Planned interim analysis
Phase II Lung Cancer trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
Slow accrual
Phase II Non-Hodgkin Lymphoma trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
Study closed early due to slow accrual
Phase IV Bipolar Disorder trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
Due to limited study staff and the COVID-19 pandemic, enrollment has been paused as staff hours for this project have been reduced and reallocated to other projects.
Phase I Non-Small Cell Lung Cancer (NSCLC) trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
slow accrual
Phase I Breast Cancer trial by Massachusetts General Hospital. Stop reason: EFFICACY/FUTILITY.
Interim analysis did not show the required cytokine induction by topical calcipotriene to justify continuation of the trial
Phase II Cutaneous Squamous Cell Carcinoma trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
The study was withdrawn due to lack of financial support.
Phase II Immunotherapy trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
The study was withdrawn due to lack of financial support.
Phase II Autism Spectrum Disorder (ASD) trial by Massachusetts General Hospital. Stop reason: OTHER/UNKNOWN.
Due to a change in the research priorities of the principal investigator in combination with low subject interest.
Phase IV Pediatric Bipolar Disorder trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
Slow subject recruitment.
Phase IV Kidney Failure trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
Unable to meet enrollment goal prior to drug expiration
Phase II Fibromyalgia trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
No funding at the current time.
Phase II Autism Spectrum Disorder trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
This study was withdrawn due to competing research interests and slow recruitment.
Phase I Metabolic Disease trial by Massachusetts General Hospital. Stop reason: EFFICACY/FUTILITY.
Futility
Phase II Autism Spectrum Disorder (ASD) trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
This study was withdrawn due to competing research interests and slow recruitment.
Phase II Covid19 trial by Massachusetts General Hospital. Stop reason: OTHER/UNKNOWN.
Decline in MISC cases
Phase IV Vaping trial by Massachusetts General Hospital. Stop reason: REGULATORY.
The pilot study used apo-varenicline under temp FDA authorization. When varenicline was available an IND exemption was granted to enroll children, IRB approved a trial of varenicline in participants ages 16-25 June 27, 2022, the pilot was terminated
Phase II Treatment-Resistant Major Depressive Disorder trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
Study was terminated due to difficulty recruiting patients who met inclusion/exclusion criteria. No participants received the intervention.
Phase IV Restless Legs Syndrome trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
No funding
Phase I Chronic Rejection trial by Massachusetts General Hospital. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase I Kidney Insufficiency trial by Massachusetts General Hospital. Stop reason: OTHER/UNKNOWN.
Protocol to be revised
Phase II Hypogonadism trial by Massachusetts General Hospital. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase I Melanoma trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
Slow accrual
Phase II Stage IV (Metastatic) Breast Cancer trial by Massachusetts General Hospital. Stop reason: OTHER/UNKNOWN.
Team decision
Phase IV Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
Due to the coronavirus disease 2019 (COVID-19) pandemic and the deleterious impact of rituximab on vaccination efficacy, the trial was concluded before reaching the target enrollment of 200.
Unknown Toxic Epidermal Necrolysis trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
PI (Responsible Party) transferred to new institution prior to enrollment and protocol was closed.
Phase IV Respiratory Failure trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
Lack of funding, transitioned to standard of care
Early Phase I Burns trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
Patient population too low to reasonably continue study, pandemic had started at time of cessation, further leading to study discontinuation.
Phase IV Pain, Postoperative trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
Original PI left institution and the PI who took over was not able to initiate the study so it was never started.
Phase I Colorectal Cancer trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
Slow Accrual
Phase II Type 1 Diabetes Mellitus trial by Massachusetts General Hospital. Stop reason: OTHER/UNKNOWN.
Devices are not available
Phase II Multiple Sclerosis, Relapsing-Remitting trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
Funding
Phase IV Kidney Failure trial by Massachusetts General Hospital. Stop reason: OTHER/UNKNOWN.
New Related Protocol to be submitted
Phase IV End Stage Liver Disease trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
Protocol transitioned to standard of care, no funding available to continue support of research work or data analysis
Phase IV End Stage Heart Disease trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
Protocol transitioned to standard of care, no funding available to support research work
Phase IV Back Pain, Low trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
Funding obtained to do a larger placebo-controlled trial
Phase IV End Stage Renal Disease trial by Massachusetts General Hospital. Stop reason: OTHER/UNKNOWN.
Single patient the protocol was written for consented to another study.
Phase III Vaping trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
Funding not received
Early Phase I Obesity trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
After discussion with the Data Safety Monitoring Board and NIH, the randomized clinical trial involving metformin vs. placebo is terminated due to slow enrollment in the setting of the COVID-19 pandemic.
Phase IV Cardiac Arrhythmias trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
Recruitment difficulties
Phase II COVID19 trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
Absence of patients meeting criteria following initial COVID surge. DMSB recommended analysis of results to date and early closure.
Phase II Colon Cancer trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
Study will be closed due to zero enrollment in over 2 years.
Phase III Amenorrhea trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
The study was not funded
Phase II Bone Metabolism trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
No recruitment
Phase II Alzheimer Disease trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
Covid restrictions
Phase I Morphea, Plaque Form trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
Difficulty in recruiting patients
Phase II Discoid Lupus Erythematosus trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
Difficulty recruiting participants
Phase III Constipation trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
PI left institution. Protocol never submitted to the IRB, no contract executed only Confidentiality Agreement, and study not done.
Phase III Sepsis trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
PI left institution. Protocol not submitted to IRB, contract not executed, and study was not done.
Phase IV Contrast Media Allergy trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
No patients enrolled as study did not move to enrollment stage
Early Phase I Pain trial by Massachusetts General Hospital. Stop reason: OTHER/UNKNOWN.
We decided to close this study and come up with a new study design.
Phase IV Rheumatoid Arthritis trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
Terminated by sponsor owing to slow enrollment
Phase IV Bipolar Disorder trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
Study was terminated due to COVID-19.
Phase II Heparin-induced Thrombocytopenia trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
Withdrawal of funding by sponsor
Phase III Sexual Dysfunction trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
Only N=8 subjects randomized; funding ran out; too small N to yield useful data.
Phase II Head and Neck Cancer trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
Funding Withdrawn
Unknown Complex Regional Pain Syndrome I (CRPS I) trial by Massachusetts General Hospital. Stop reason: OTHER/UNKNOWN.
Due to limited population of research participants.
Phase I Giant Cell Arteritis trial by Massachusetts General Hospital. Stop reason: OTHER/UNKNOWN.
Inefficacy
Unknown Brain and Central Nervous System Tumors trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
Funding ended
Phase II Obstructed Defecation Syndrome (ODS) trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
Low recruitment
Phase I Anesthesia trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
We have decided to withdraw the study prior to enrollment of the first participant in order to pursue other research studies.
Phase IV Pulmonary Embolism trial by Massachusetts General Hospital. Stop reason: OTHER/UNKNOWN.
Gadolinium attenuation in vitro inadequate
Phase IV Hepatitis C trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
No participant enrollment, funding withdrawn.
Unknown Hepatitis C trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
Unable to meet enrollment goal
Phase IV Premenstrual Syndrome trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
Cancellation of funding contract
Unknown Type 1 Diabetes Mellitus trial by Massachusetts General Hospital. Stop reason: OTHER/UNKNOWN.
Lack of appropriate funds
Unknown Diabetes Mellitus Type 1 trial by Massachusetts General Hospital. Stop reason: OTHER/UNKNOWN.
The study was terminated prior to completing the planned cohorts and analysis because of problems with the infusion set resulting in inadequate insulin delivery
Phase IV Depressive Disorder trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
Site was unable to reach Sponsor recruitment goals.
Phase IV Constipation trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
Slow recruitment and inability to extend funding.
Phase I Multiple Myeloma trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
Funding withdrawn by sponsor
Unknown Diabetes trial by Massachusetts General Hospital. Stop reason: OTHER/UNKNOWN.
Potential subjects were already on the combination therapy.
Phase I Small Bowel Carcinoid Tumor trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
Slow accrual
Phase I Keratosis, Actinic trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
Lack of funding.
Phase IV Renal Failure Chronic trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
Withdrew IRB application, never approved and no subjects enrolled
Phase I HIV/AIDS trial by Massachusetts General Hospital. Stop reason: OTHER/UNKNOWN.
The study closed because of shifting research priorities and interests.
Phase II Painful Neuropathy trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
poor enrollment
Phase I Graft-vs-Host Disease trial by Massachusetts General Hospital. Stop reason: SAFETY.
Toxicity
Phase IV Mania trial by Massachusetts General Hospital. Stop reason: OTHER/UNKNOWN.
On hold due to competing departmental studies
Phase IV Nasal Polyps trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
Inability to recruit additional subjects.
Unknown Cystic Fibrosis trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
We were unable to enroll eligible subjects for the study.
Phase I AML trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
Funding Withdrawn
Unknown Depression trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.
Funding ended.