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M.D. Anderson Cancer Center clinical trial failures
Review 388 stopped clinical trials from M.D. Anderson Cancer Center, including disease areas, phases, and classified stop reasons.
This page groups real ClinicalTrials.gov-derived stopped trial records. The strongest added signal is the stop-reason classification: 15 of these records are likely biological failure signals, while the rest may reflect operational, strategic, regulatory, funding, enrollment, or unclear stop reasons.
Dominant stop reasons
- OPERATIONAL
- 200
- OTHER/UNKNOWN
- 172
- SAFETY
- 8
- EFFICACY/FUTILITY
- 7
- REGULATORY
- 1
Notable sponsors
- M.D. Anderson Cancer Center
- 388
Related phases
- Phase II
- 188
- Phase I
- 152
- Phase III
- 16
- Unknown
- 14
- Early Phase I
- 12
Crawlable stopped-trial records
Open ExploreShowing up to 100 representative records from this slice. Each link opens the trial detail page with source attribution and stop-reason context.
Phase I Pancreatic Cancer trial by M.D. Anderson Cancer Center. Stop reason: OPERATIONAL.
PI Request
Phase II Uterine Leiomyosarcoma trial by M.D. Anderson Cancer Center. Stop reason: OPERATIONAL.
PI Request
Phase I Breast Cancer trial by M.D. Anderson Cancer Center. Stop reason: SAFETY.
Toxicity and Lack of Efficacy
Phase II Chronic Myelomonocytic Leukemia trial by M.D. Anderson Cancer Center. Stop reason: OPERATIONAL.
PI request
Phase II Metastatic Cancer trial by M.D. Anderson Cancer Center. Stop reason: OPERATIONAL.
PI request
Phase I Recurrent Chronic Myelomonocytic Leukemia trial by M.D. Anderson Cancer Center. Stop reason: OTHER/UNKNOWN.
\<75% participation
Phase II Colorectal Cancer trial by M.D. Anderson Cancer Center. Stop reason: OPERATIONAL.
PI requested
Phase I Pediatric Acute Leukemia trial by M.D. Anderson Cancer Center. Stop reason: OPERATIONAL.
PI requested
Early Phase I Pancreatic Ductal Adenocarcinoma trial by M.D. Anderson Cancer Center. Stop reason: OPERATIONAL.
PI request
Phase II AML trial by M.D. Anderson Cancer Center. Stop reason: OTHER/UNKNOWN.
\<75% participation
Phase I Advanced Malignant Neoplasm trial by M.D. Anderson Cancer Center. Stop reason: OTHER/UNKNOWN.
\< 75 % participation
Phase II Allogeneic Stem Cell Transplantation trial by M.D. Anderson Cancer Center. Stop reason: OTHER/UNKNOWN.
Abandoned
Phase I Leukemia trial by M.D. Anderson Cancer Center. Stop reason: OPERATIONAL.
PI Request
Phase I Recurrent B Acute Lymphoblastic Leukemia trial by M.D. Anderson Cancer Center. Stop reason: OTHER/UNKNOWN.
\<75% participation
Phase II HPV trial by M.D. Anderson Cancer Center. Stop reason: OTHER/UNKNOWN.
0 participants
Phase II Metastatic Castration Resistant Prostate Cancer trial by M.D. Anderson Cancer Center. Stop reason: OPERATIONAL.
PI requested
Phase I Phase I trial by M.D. Anderson Cancer Center. Stop reason: OPERATIONAL.
PI requested
Phase II Microsatellite High Cancers trial by M.D. Anderson Cancer Center. Stop reason: OPERATIONAL.
PI Request
Phase II Borderline Resectable Pancreatic Adenocarcinoma trial by M.D. Anderson Cancer Center. Stop reason: OTHER/UNKNOWN.
0 participants
Phase II Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 trial by M.D. Anderson Cancer Center. Stop reason: OTHER/UNKNOWN.
\<75% participation
Phase I Advanced Bladder Carcinoma trial by M.D. Anderson Cancer Center. Stop reason: OPERATIONAL.
PI requested.
Phase II Acute Lymphoblastic Leukemia trial by M.D. Anderson Cancer Center. Stop reason: OTHER/UNKNOWN.
\< 75% participation
Phase II Recurrent Plasma Cell Myeloma trial by M.D. Anderson Cancer Center. Stop reason: OTHER/UNKNOWN.
\<75% participation
Phase I Acute Myeloid Leukemia trial by M.D. Anderson Cancer Center. Stop reason: OTHER/UNKNOWN.
75% \> Participants
Phase II Acute Lymphoblastic Leukemia trial by M.D. Anderson Cancer Center. Stop reason: OTHER/UNKNOWN.
\<75% participation
Phase I Ovarian Cancer trial by M.D. Anderson Cancer Center. Stop reason: OTHER/UNKNOWN.
Suspension
Phase I Leukemia trial by M.D. Anderson Cancer Center. Stop reason: OPERATIONAL.
Slow participant enrollment
Phase I Advanced Solid Tumor trial by M.D. Anderson Cancer Center. Stop reason: OTHER/UNKNOWN.
Sponsor discontinued the trial
Phase I Advanced Cancers trial by M.D. Anderson Cancer Center. Stop reason: OTHER/UNKNOWN.
\<75% participation
Phase II Metastatic Cancer trial by M.D. Anderson Cancer Center. Stop reason: OPERATIONAL.
PI request
Phase II Thyroid trial by M.D. Anderson Cancer Center. Stop reason: OPERATIONAL.
\<75% participant accrual
Phase II Advanced Clear Cell Renal Cell Carcinoma trial by M.D. Anderson Cancer Center. Stop reason: OPERATIONAL.
Withdrawal of funding from the supporter (Mirati Therapeutics)
Phase II Microsatellite-stable Colorectal Cancer trial by M.D. Anderson Cancer Center. Stop reason: OPERATIONAL.
PI Request
Phase I Recurrent Cutaneous Melanoma trial by M.D. Anderson Cancer Center. Stop reason: OTHER/UNKNOWN.
\<75% participation
Phase I Anatomic Stage IV Breast Cancer AJCC v8 trial by M.D. Anderson Cancer Center. Stop reason: OPERATIONAL.
Insufficient accrual
Phase II Castration-Resistant Prostate Carcinoma trial by M.D. Anderson Cancer Center. Stop reason: OTHER/UNKNOWN.
\<75% participation
Phase I Colorectal Cancer trial by M.D. Anderson Cancer Center. Stop reason: OTHER/UNKNOWN.
0 participants enrolled
Phase II Acute Myeloid Leukemia trial by M.D. Anderson Cancer Center. Stop reason: OTHER/UNKNOWN.
\<75% participation
Phase I Advanced Lung Carcinoma trial by M.D. Anderson Cancer Center. Stop reason: OTHER/UNKNOWN.
\<75% participation
Phase II Philadelphia Chromosome Negative, BCR-ABL1 Positive Chronic Myelogenous Leukemia trial by M.D. Anderson Cancer Center. Stop reason: OTHER/UNKNOWN.
75% \< Participants, Administrativley Complete
Phase II Rectal Cancer trial by M.D. Anderson Cancer Center. Stop reason: OTHER/UNKNOWN.
0 participants enrolled
Phase II EGFR Exon 20 Mutation trial by M.D. Anderson Cancer Center. Stop reason: OTHER/UNKNOWN.
\<75% participation
Phase II Metastatic Colorectal Carcinoma trial by M.D. Anderson Cancer Center. Stop reason: OTHER/UNKNOWN.
\< 75% participation
Phase I Pathway Mutant Myelodysplastic Syndromes trial by M.D. Anderson Cancer Center. Stop reason: OTHER/UNKNOWN.
Drug Source Request
Phase I Angiosarcoma trial by M.D. Anderson Cancer Center. Stop reason: OPERATIONAL.
No participants enrolled
Phase I Chronic Myelomonocytic Leukemia trial by M.D. Anderson Cancer Center. Stop reason: OTHER/UNKNOWN.
\<75% participation
Phase I Breast Inflammatory Carcinoma trial by M.D. Anderson Cancer Center. Stop reason: OTHER/UNKNOWN.
\<75% accrued
Phase II Castration-Resistant Prostate Carcinoma trial by M.D. Anderson Cancer Center. Stop reason: OTHER/UNKNOWN.
\<75% participation
Phase II Metastatic Head and Neck Squamous Cell Carcinoma trial by M.D. Anderson Cancer Center. Stop reason: OTHER/UNKNOWN.
\<75% participation
Phase II Endometrial Cancer trial by M.D. Anderson Cancer Center. Stop reason: OTHER/UNKNOWN.
Copanlisib development was discontinued by Bayer following withdrawal of copanlisib in relapsed follicular lymphoma in November 2023.
Phase II Hormone Receptor-positive Human Epidermal Growth Factor 2-negative trial by M.D. Anderson Cancer Center. Stop reason: OTHER/UNKNOWN.
\<75% Participation
Phase I RAS Wild Type trial by M.D. Anderson Cancer Center. Stop reason: OTHER/UNKNOWN.
\<75% participation
Phase I Head and Neck Squamous Cell Carcinoma trial by M.D. Anderson Cancer Center. Stop reason: OPERATIONAL.
PI requested
Phase I Chronic Lymphocytic Leukemia trial by M.D. Anderson Cancer Center. Stop reason: OTHER/UNKNOWN.
\<75% participation
Phase I Blasts 5 Percent or More of Bone Marrow Nucleated Cells trial by M.D. Anderson Cancer Center. Stop reason: OTHER/UNKNOWN.
\<75% participation
Early Phase I Squamous Cell Carcinoma of Head and Neck trial by M.D. Anderson Cancer Center. Stop reason: OTHER/UNKNOWN.
0 participants
Phase I Metastatic Pancreatic Cancer trial by M.D. Anderson Cancer Center. Stop reason: OTHER/UNKNOWN.
\<75 % participation
Phase II Leukemia trial by M.D. Anderson Cancer Center. Stop reason: OPERATIONAL.
Closed due to slow accrual
Phase II Kidney Medullary Carcinoma trial by M.D. Anderson Cancer Center. Stop reason: EFFICACY/FUTILITY.
The study met its prespecified futility criteria during the prespecified interim futility analysis after enrolling the first cohort of 10 patients.
Phase II Leukemia, Lymphoblastic trial by M.D. Anderson Cancer Center. Stop reason: OPERATIONAL.
The sponsor requested termination due to internal reprioritization of resources.
Phase I Melanoma trial by M.D. Anderson Cancer Center. Stop reason: OPERATIONAL.
\<75% participant accrual
Phase I Multiple Myeloma trial by M.D. Anderson Cancer Center. Stop reason: OTHER/UNKNOWN.
\<75% participation
Phase I Bronchiolitis Obliterans trial by M.D. Anderson Cancer Center. Stop reason: OTHER/UNKNOWN.
\<75% participation
Phase I Hematopoietic and Lymphoid Cell Neoplasm trial by M.D. Anderson Cancer Center. Stop reason: OTHER/UNKNOWN.
The study terminated early because the company was longer providing the investigational product.
Phase II Head Neck trial by M.D. Anderson Cancer Center. Stop reason: OPERATIONAL.
Slow Accrual
Phase II Leukemia trial by M.D. Anderson Cancer Center. Stop reason: OPERATIONAL.
Slow Accrual
Phase II Anatomic Stage I Breast Cancer AJCC v8 trial by M.D. Anderson Cancer Center. Stop reason: OTHER/UNKNOWN.
\<75% participation
Phase II B-cell Lymphoma trial by M.D. Anderson Cancer Center. Stop reason: OPERATIONAL.
PI Request
Phase II Acute Lymphoblastic Leukemia trial by M.D. Anderson Cancer Center. Stop reason: OPERATIONAL.
PI Request. Slow accrual and lack of clinical interest
Phase I Recurrent Waldenstrom Macroglobulinemia trial by M.D. Anderson Cancer Center. Stop reason: OPERATIONAL.
\<75% participant accrual
Phase II Locally Advanced Angiosarcoma trial by M.D. Anderson Cancer Center. Stop reason: OPERATIONAL.
PI request, \<75% participation
Phase II Squamous Cell Carcinoma trial by M.D. Anderson Cancer Center. Stop reason: OTHER/UNKNOWN.
0 participants
Phase II Renal Cell Carcinoma trial by M.D. Anderson Cancer Center. Stop reason: OTHER/UNKNOWN.
0 participants
Phase I Recurrent Adult Lymphoblastic Lymphoma trial by M.D. Anderson Cancer Center. Stop reason: OPERATIONAL.
The study was terminated early due to slow enrollment.
Phase I Refractory Acute Leukemia trial by M.D. Anderson Cancer Center. Stop reason: OTHER/UNKNOWN.
0 participants
Phase II Lung Squamous Cell Carcinoma trial by M.D. Anderson Cancer Center. Stop reason: OTHER/UNKNOWN.
0 participants
Early Phase I Hematopoietic and Lymphoid Cell Neoplasm trial by M.D. Anderson Cancer Center. Stop reason: OTHER/UNKNOWN.
\<75% participation
Phase I Metastatic Pancreatic Cancer trial by M.D. Anderson Cancer Center. Stop reason: OPERATIONAL.
No participants enrolled
Phase II Desmoplastic Small Round Cell Tumor trial by M.D. Anderson Cancer Center. Stop reason: OPERATIONAL.
PI Request
Phase II Adrenocortical Carcinoma trial by M.D. Anderson Cancer Center. Stop reason: OPERATIONAL.
Slow accrual
Phase I Breast Inflammatory Carcinoma trial by M.D. Anderson Cancer Center. Stop reason: OTHER/UNKNOWN.
Termination was requested by study supporter IKENA oncology
Phase I Metastatic Breast Cancer trial by M.D. Anderson Cancer Center. Stop reason: OPERATIONAL.
Sponsor Withdrew Support
Phase I Platinum-Resistant Fallopian Tube Carcinoma trial by M.D. Anderson Cancer Center. Stop reason: OPERATIONAL.
PI Request
Phase II Recurrent B Acute Lymphoblastic Leukemia trial by M.D. Anderson Cancer Center. Stop reason: OPERATIONAL.
Study was closed early due to low accrual and lack of response.
Phase I Leukemia trial by M.D. Anderson Cancer Center. Stop reason: OTHER/UNKNOWN.
Study was stopped by the principal investigator due to nonsatisfactory clinical benefit even in patients treated at the highest dose (200 mg ).
Phase I Advanced Malignant Solid Neoplasm trial by M.D. Anderson Cancer Center. Stop reason: OPERATIONAL.
Administratively Complete
Phase I Chronic Myelogenous Leukemia, BCR-ABL1 Positive trial by M.D. Anderson Cancer Center. Stop reason: OPERATIONAL.
Per PI Request. 2) No additional benefit was noted with the addition of Ruxolitinib.
Phase I Hematopoietic and Lymphoid Cell Neoplasm trial by M.D. Anderson Cancer Center. Stop reason: OPERATIONAL.
supporting/funding source decided to de-prioritize and stop development of DS-1594
Phase II Myelofibrosis trial by M.D. Anderson Cancer Center. Stop reason: OPERATIONAL.
0 participant accrual
Phase II Advanced Malignant Solid Neoplasm trial by M.D. Anderson Cancer Center. Stop reason: OTHER/UNKNOWN.
There is no PR/CR observed in the first stage, so study stopped without proceeding to the stage 2 of efficacy stage.
Phase I Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive trial by M.D. Anderson Cancer Center. Stop reason: OPERATIONAL.
The study was terminated early due to slow accrual and low level of interest both by the sponsor and by the department
Phase I Glioblastoma trial by M.D. Anderson Cancer Center. Stop reason: OPERATIONAL.
\<75 % participant accrual
Phase II Pancreatic Cancer trial by M.D. Anderson Cancer Center. Stop reason: EFFICACY/FUTILITY.
Significant Adverse Effects - Futility
Phase II Non-small Cell Lung Cancer trial by M.D. Anderson Cancer Center. Stop reason: OTHER/UNKNOWN.
0 participants enrolled
Phase II Prostate Adenocarcinoma trial by M.D. Anderson Cancer Center. Stop reason: OTHER/UNKNOWN.
Committee could not find that the regulatory approval are met to re-approve this study.
Phase II Recurrent Mantle Cell Lymphoma trial by M.D. Anderson Cancer Center. Stop reason: OPERATIONAL.
Administratively Complete 75%\<Participants
Phase II Malignant Solid Neoplasm trial by M.D. Anderson Cancer Center. Stop reason: EFFICACY/FUTILITY.
Lack of Efficacy
Early Phase I Head and Neck Squamous Cell Carcinoma trial by M.D. Anderson Cancer Center. Stop reason: OPERATIONAL.
PI Request
Phase I Advanced Cancers trial by M.D. Anderson Cancer Center. Stop reason: OTHER/UNKNOWN.
75%\<Participants
Phase I Acute Myeloid Leukemia trial by M.D. Anderson Cancer Center. Stop reason: OPERATIONAL.
PI Request