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H. Lee Moffitt Cancer Center and Research Institute clinical trial failures
Review 55 stopped clinical trials from H. Lee Moffitt Cancer Center and Research Institute, including disease areas, phases, and classified stop reasons.
This page groups real ClinicalTrials.gov-derived stopped trial records. The strongest added signal is the stop-reason classification: 7 of these records are likely biological failure signals, while the rest may reflect operational, strategic, regulatory, funding, enrollment, or unclear stop reasons.
Dominant stop reasons
- OPERATIONAL
- 32
- OTHER/UNKNOWN
- 16
- EFFICACY/FUTILITY
- 5
- SAFETY
- 2
Notable sponsors
- H. Lee Moffitt Cancer Center and Research Institute
- 55
Related phases
- Phase II
- 23
- Phase I
- 21
- Early Phase I
- 7
- Unknown
- 4
Crawlable stopped-trial records
Open ExploreShowing up to 55 representative records from this slice. Each link opens the trial detail page with source attribution and stop-reason context.
Phase I HER2-positive Breast Cancer trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: OTHER/UNKNOWN.
Wait for the DLT period with our current patient and will not be enrolling any more.
Phase I Bladder Cancer trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: OPERATIONAL.
Slow Accrual
Phase I Non Small Cell Lung Cancer trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: OTHER/UNKNOWN.
Drugs unavailable
Phase II Renal Cell Carcinoma trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: OPERATIONAL.
Funding unavailable
Phase II Chronic Lymphocytic Leukemia trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: OPERATIONAL.
Funding unavailable
Early Phase I Mycosis Fungoides trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: OPERATIONAL.
Slow Accrual
Early Phase I Large Granular Lymphocyte Leukemia trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: EFFICACY/FUTILITY.
lack of efficacy/futility
Phase I Acute Myeloid Leukemia trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: SAFETY.
Toxicity -Two DLT events occurred
Phase II Chronic Lymphocytic Leukemia trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: OTHER/UNKNOWN.
Drug no longer available
Phase I Myeloproliferative Neoplasm trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: OTHER/UNKNOWN.
Did not advance to Phase 2
Phase I Recurrent High-grade Glioma trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: OPERATIONAL.
funding issues
Phase I Small-cell Lung Cancer trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: SAFETY.
DLTs
Early Phase I Cutaneous Squamous Cell Carcinoma trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: OPERATIONAL.
Poor accrual
Early Phase I Glioma of Brain trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: OPERATIONAL.
Funding unavailable
Phase II Small Cell Lung Cancer trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: OTHER/UNKNOWN.
Sponsor closed study
Phase II Multiple Myeloma trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: OTHER/UNKNOWN.
Sponsor no longer providing drug
Phase I Carcinoma, Non-Small-Cell Lung trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: OTHER/UNKNOWN.
Increased SAE occurrence per PI
Phase I Myelodysplastic Syndrome (MDS) trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: EFFICACY/FUTILITY.
Lack of efficacy
Phase II Cutaneous Squamous Cell Carcinoma trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: OTHER/UNKNOWN.
Lack of Interest
Phase II Angiosarcoma of Skin trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: OPERATIONAL.
Sponsor Terminated Funding
Phase I Hepatocellular Carcinoma trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: OPERATIONAL.
Loss of funding
Phase II Carcinoma in Situ of Bladder trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: EFFICACY/FUTILITY.
Study closed early due to futility
Phase II Breast Cancer trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: OPERATIONAL.
lost funding
Phase II Breast Cancer trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: OPERATIONAL.
Quality of the data originating from prior versions of the protocol has been affected by protocol deviations triggered by the COVID-19 pandemics
Phase II Thyroid Cancer trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: EFFICACY/FUTILITY.
Lack of efficacy
Early Phase I Pancreatic Cancer trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: OPERATIONAL.
Lack of funding
Phase I Brain Metastases trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: OPERATIONAL.
lack of funding by company providing TPI-287
Phase I Breast Cancer trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: OPERATIONAL.
PI left Abramson Cancer Center and study never opened at Moffitt Cancer Center.
Early Phase I Breast Cancer trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: OTHER/UNKNOWN.
closure of radiolaboratory
Phase II Gastro-enteropancreatic Neuroendocrine Tumor trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: OPERATIONAL.
Slow accrual
Phase II Non Small Cell Lung Cancer trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: OPERATIONAL.
Funding unavailable
Phase I HepatoCellular Carcinoma trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: OPERATIONAL.
No Interest. Investigator was unable to enroll any participants on study.
Phase II Bladder Cancer trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: OTHER/UNKNOWN.
Grant not approved
Phase II Melanoma trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: EFFICACY/FUTILITY.
Treatment Ineffective
Phase I Lung Cancer trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: OPERATIONAL.
Funding unavailable
Early Phase I Ovarian Cancer trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: OPERATIONAL.
Drug manufacturing issues
Unknown Ovarian Cancer trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: OTHER/UNKNOWN.
Funds for this project have been spent, and it is thereby terminated.
Phase II Pancreatic Neoplasms trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: OPERATIONAL.
Abandoned - Lack of funding after only 2 patients enrolled
Phase I Neuroblastoma trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: OPERATIONAL.
no enrollment
Phase I Multiple Myeloma trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: OTHER/UNKNOWN.
study drug unavailable
Unknown Acute Myeloid Leukemia (AML) trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: OPERATIONAL.
Low accrual
Phase I Non-Small Cell Lung Cancer trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: OPERATIONAL.
slow accrual
Phase II Lung Cancer trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: OPERATIONAL.
slow accrual - the 1 patient accrued did not go on treatment
Phase II Astrocytoma trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: OPERATIONAL.
Principal Investigator left Moffitt and study had low accrual.
Phase I Mesothelioma trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: OPERATIONAL.
Slow Accrual
Phase II Pancreatic Cancer trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: OTHER/UNKNOWN.
Development of new chemotherapy standard of care for treatment rendered the trial obsolete.
Phase II Adenocarcinoma trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: OPERATIONAL.
drug now on market
Phase I Brain Metastases trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: OPERATIONAL.
Lack of enrollment
Unknown Breast Cancer trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Unknown Peripheral T-Cell Lymphoma trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: OPERATIONAL.
Slow accrual, loss of sponsor support
Phase II Melanoma trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: OPERATIONAL.
no accrual
Phase I Esophageal Cancer trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: OPERATIONAL.
Principal Investigator left the institution
Phase II Pancreatic Cancer trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: OTHER/UNKNOWN.
Lack of pre-treatment tissue to make the study plan feasible.
Phase I Tumor trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: OTHER/UNKNOWN.
Drugs unavailable. Study did not progress to Phase 2.
Phase II Neuroendocrine Carcinoma trial by H. Lee Moffitt Cancer Center and Research Institute. Stop reason: OPERATIONAL.
Slow accrual