Sponsor hub
Duke University clinical trial failures
Review 97 stopped clinical trials from Duke University, including disease areas, phases, and classified stop reasons.
This page groups real ClinicalTrials.gov-derived stopped trial records. The strongest added signal is the stop-reason classification: 4 of these records are likely biological failure signals, while the rest may reflect operational, strategic, regulatory, funding, enrollment, or unclear stop reasons.
Dominant stop reasons
- OPERATIONAL
- 62
- OTHER/UNKNOWN
- 31
- EFFICACY/FUTILITY
- 2
- SAFETY
- 2
Notable sponsors
- Duke University
- 97
Related phases
- Phase II
- 34
- Phase IV
- 30
- Phase I
- 17
- Unknown
- 12
- Phase III
- 3
Crawlable stopped-trial records
Open ExploreShowing up to 97 representative records from this slice. Each link opens the trial detail page with source attribution and stop-reason context.
Unknown Intra-Articular Fractures trial by Duke University. Stop reason: OPERATIONAL.
Low accrual
Phase II Non Small Cell Lung Cancer trial by Duke University. Stop reason: OTHER/UNKNOWN.
Protocol is currently undergoing study design revisions and will re-open after amendment is IRB approved
Phase II Kidney Transplant trial by Duke University. Stop reason: OPERATIONAL.
The study closed per PI decision due to completion of the biopsy substudy and slow accrual
Phase I Juvenile Idiopathic Arthritis trial by Duke University. Stop reason: OPERATIONAL.
Funding expired
Phase I Amputation trial by Duke University. Stop reason: OPERATIONAL.
low enrollment
Phase I Recurrent or Progressive High-grade Glioma trial by Duke University. Stop reason: OTHER/UNKNOWN.
Immorna, the funder withdrew the funds to run this study
Phase II Prostate Cancer trial by Duke University. Stop reason: OPERATIONAL.
Discontinuation of funding
Unknown COPD trial by Duke University. Stop reason: OPERATIONAL.
COVID-19 hold
Phase IV Pain trial by Duke University. Stop reason: OPERATIONAL.
Budgetary issues
Phase IV Pain, Postoperative trial by Duke University. Stop reason: OPERATIONAL.
Lack of funding
Phase I CML (Chronic Myelogenous Leukemia trial by Duke University. Stop reason: OPERATIONAL.
Study halted prematurely, prior to enrollment of first participant.
Phase IV Pulmonary Hypertension trial by Duke University. Stop reason: OTHER/UNKNOWN.
Project was completed
Phase IV Individuals Undergoing Cardiac and General Surgery trial by Duke University. Stop reason: EFFICACY/FUTILITY.
Showed no benefit
Phase II Acute Lung Injury trial by Duke University. Stop reason: OPERATIONAL.
Terminated by new sponsor due to funding issues.
Phase IV Pulmonary Hypertension trial by Duke University. Stop reason: OPERATIONAL.
slow enrollment
Phase IV Fatty Liver trial by Duke University. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase II Non Small Cell Lung Cancer trial by Duke University. Stop reason: OPERATIONAL.
low accrual
Phase IV Schizophrenia trial by Duke University. Stop reason: OPERATIONAL.
PI left institution
Phase IV Malignant Pleural Effusion trial by Duke University. Stop reason: OPERATIONAL.
Study enrollment not met
Phase III Sickle Cell Disease trial by Duke University. Stop reason: OPERATIONAL.
Due to COVID enrollment numbers needed to meet the primary endpoint will not be met.
Phase II Chronic Obstructive Pulmonary Disease (COPD) trial by Duke University. Stop reason: OPERATIONAL.
Study halted prematurely due to funding, prior to enrollment of first participant
Phase II Glioma trial by Duke University. Stop reason: OTHER/UNKNOWN.
Did not enroll as planned
Phase IV Hypertension in Pregnancy trial by Duke University. Stop reason: OPERATIONAL.
Unable to continue recruiting
Phase II Brain Metastases trial by Duke University. Stop reason: OTHER/UNKNOWN.
failure to enroll
Phase I Hyperglycemia Drug Induced trial by Duke University. Stop reason: OPERATIONAL.
Lack of enrollment
Phase II Pompe Disease (Late-onset) trial by Duke University. Stop reason: OPERATIONAL.
hasn't got the funding
Phase IV Hip Osteoarthritis trial by Duke University. Stop reason: OTHER/UNKNOWN.
Study halted prematurely and will not resume; participants are no longer being examined or receiving any intervention.
Phase II Prostate Cancer trial by Duke University. Stop reason: OPERATIONAL.
Poor accrual.
Phase IV Pain trial by Duke University. Stop reason: OPERATIONAL.
Study halted prematurely, prior to enrollment of first participant
Phase II Autism Spectrum Disorder trial by Duke University. Stop reason: OPERATIONAL.
The study stopped recruitment of new participants due to COVID. A substudy was developed with adaptations to the main design.
Phase IV Anemia trial by Duke University. Stop reason: OTHER/UNKNOWN.
Decided not to open study
Phase IV Pain, Postoperative trial by Duke University. Stop reason: OTHER/UNKNOWN.
Decline of eligible participants
Phase II Cataract Surgery trial by Duke University. Stop reason: OTHER/UNKNOWN.
PI decided not to open study
Phase I Dexmedetomidine trial by Duke University. Stop reason: OPERATIONAL.
Enrollment challenging during the pandemic COVID 19
Phase IV HIV/AIDS trial by Duke University. Stop reason: OPERATIONAL.
COVID prevented study initiation
Phase I Hyperglycemia Drug Induced trial by Duke University. Stop reason: OPERATIONAL.
poor accrual
Phase II SARS-CoV-2 trial by Duke University. Stop reason: OPERATIONAL.
Poor recruitment, strong evidence from larger trials of no therapeutic benefit
Phase I Falciparum Malaria trial by Duke University. Stop reason: OPERATIONAL.
current grant expiration in May, insufficient funds remaining, travel restrictions, COVID-19 restrictions in Tanzania, etc.
Phase II Lumbar Disc Disease trial by Duke University. Stop reason: OPERATIONAL.
No funding source
Phase IV Erythrocyte Transfusion trial by Duke University. Stop reason: OTHER/UNKNOWN.
Reagent shortage
Phase IV Infantile Neuroaxonal Dystrophy trial by Duke University. Stop reason: OPERATIONAL.
Funding exhausted
Phase IV Pre-eclampsia trial by Duke University. Stop reason: OPERATIONAL.
Significant challenges recruiting a difficult patient population with most surgeries occurring out of hours
Phase IV Hypertrophic Cardiomyopathy trial by Duke University. Stop reason: OPERATIONAL.
Sponsor withdrew funding
Phase IV Deep Sedation trial by Duke University. Stop reason: OPERATIONAL.
All enrolled participants completed the study protocol but the study was terminated prior to the goal number of participants due to low recruitment
Phase IV Systemic Sclerosis trial by Duke University. Stop reason: OTHER/UNKNOWN.
The device that was going to be studied was removed by Duke University shortly after the study was approved.
Unknown CT of the Abdomen and Pelvis With Contrast Material trial by Duke University. Stop reason: OPERATIONAL.
Slow enrollment.
Phase IV Heart Defects, Congenital trial by Duke University. Stop reason: OTHER/UNKNOWN.
Product unavailability
Phase I Cardiovascular Diseases trial by Duke University. Stop reason: OTHER/UNKNOWN.
Lack of participants
Phase IV Any Condition Requiring Vulvar Biopsy trial by Duke University. Stop reason: OPERATIONAL.
interim analysis produced significant results, so we ended enrollment
Phase IV Venous Thromboembolism trial by Duke University. Stop reason: OPERATIONAL.
Lack of enrollment
Phase IV Pain trial by Duke University. Stop reason: OTHER/UNKNOWN.
Insufficient staff
Phase IV Hepatitis C, Chronic trial by Duke University. Stop reason: OPERATIONAL.
Enrollment terminated due to not having any other eligible participants.
Phase II Delirium trial by Duke University. Stop reason: OPERATIONAL.
No participants enrolled in study.
Phase II Lung Transplant Rejection trial by Duke University. Stop reason: OTHER/UNKNOWN.
Not activated at Duke
Phase II Post Traumatic Stress Disorder trial by Duke University. Stop reason: OPERATIONAL.
Terminated due to slow enrollment.
Phase II Glioblastoma Multiforme trial by Duke University. Stop reason: SAFETY.
Study ended early due to toxicity
Phase I Melanoma trial by Duke University. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase II Nicotine Dependence trial by Duke University. Stop reason: OTHER/UNKNOWN.
Study design changed significantly; was submitted as a different protocol.
Phase I Breast Cancer Triple Negative trial by Duke University. Stop reason: OPERATIONAL.
Inadequate enrollment
Phase I Nicotine Dependence trial by Duke University. Stop reason: OTHER/UNKNOWN.
Unable to obtain varenicline to provide to participants
Phase III Mitral Valve Insufficiency trial by Duke University. Stop reason: OPERATIONAL.
Unable to recruit sufficient numbers of patients.
Phase IV Urinary Urge Incontinence trial by Duke University. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase II Otitis Media With Effusion trial by Duke University. Stop reason: OPERATIONAL.
On clinical hold with the FDA. Insufficient funds to conduct the study
Phase IV Schizophrenia trial by Duke University. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Unknown Adverse Effects of Angiotensin-converting-enzyme Inhibitors trial by Duke University. Stop reason: EFFICACY/FUTILITY.
Following an interim analysis the study team felt that there was enough data that showed no significant difference.
Unknown Laparoscopic Colorectal Resection trial by Duke University. Stop reason: OPERATIONAL.
Poor recruitment
Phase IV Acute Infection of Total Knee Replacement trial by Duke University. Stop reason: OPERATIONAL.
Difficulty with enrollment
Unknown Neovascular Age-related Macular Degeneration trial by Duke University. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Unknown End Stage Renal Disease trial by Duke University. Stop reason: OPERATIONAL.
Lack of enrollment
Phase I Breast Cancer trial by Duke University. Stop reason: OPERATIONAL.
Enrollment did not meet anticipated goals. Eligibility was a challenge.
Phase II Multiple Myeloma trial by Duke University. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase II Exercise Training trial by Duke University. Stop reason: OPERATIONAL.
Lack of funding required to enroll target subject number
Phase III Lumbar Spine Fusion trial by Duke University. Stop reason: OPERATIONAL.
Lack of recruitment.
Early Phase I Focus is Determination of the Role of SNO-Hb in Forearm Blood Flow Regulation trial by Duke University. Stop reason: OPERATIONAL.
Lack of funding
Unknown Pain Management Strategies in Liver Resection Surgery trial by Duke University. Stop reason: OPERATIONAL.
Unable to recruit subjects
Phase II Follicular Lymphoma trial by Duke University. Stop reason: OTHER/UNKNOWN.
The study closed temporarily in February 2012 pending analysis of samples collected. In October, 2012, Celgene requested closure of the study.
Phase II Autism Spectrum Disorders trial by Duke University. Stop reason: OPERATIONAL.
lack of funding
Phase II Non Small Cell Lung Cancer trial by Duke University. Stop reason: OPERATIONAL.
Poor accrual
Phase II Myelodysplastic Syndromes trial by Duke University. Stop reason: OTHER/UNKNOWN.
Early closure of study due to poor response
Phase I Breast Cancer trial by Duke University. Stop reason: OPERATIONAL.
Funding
Phase IV Pain trial by Duke University. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase II Anemia trial by Duke University. Stop reason: OPERATIONAL.
Lack of Enrollment
Phase II Melanoma trial by Duke University. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase II Prostate Cancer trial by Duke University. Stop reason: SAFETY.
Dose Limiting Toxicities
Unknown Coagulation Changes With Oxytocin trial by Duke University. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase II Early-Stage Breast Cancer trial by Duke University. Stop reason: OTHER/UNKNOWN.
Study terminated due to reproducibility issues with genomics prediction model
Unknown Neurocognitive Dysfunction trial by Duke University. Stop reason: OPERATIONAL.
Principal Investigator decided not to pursue enrollment due to changes in standard of care.
Phase I Refractory Solid Tumors trial by Duke University. Stop reason: OPERATIONAL.
Low accrual, unable to meet endpoint in timely manner
Unknown Goal-oriented Fluid Therapy trial by Duke University. Stop reason: OPERATIONAL.
Very slow accrual because sites have few open colorectal surgery
Phase II Mantle-Cell Lymphoma trial by Duke University. Stop reason: OPERATIONAL.
Low accrual due to the approval of new drugs for use in Mantle cell lymphoma.
Phase II Age-related Macular Degeneration trial by Duke University. Stop reason: OPERATIONAL.
Inadequate support to complete recruitment/data analysis.
Phase IV Type 2 Diabetes Mellitus trial by Duke University. Stop reason: OPERATIONAL.
The study was stopped due to poor enrollment.
Phase I Metastatic Melanoma trial by Duke University. Stop reason: OTHER/UNKNOWN.
The PI retired
Phase I Melanoma (Skin) trial by Duke University. Stop reason: OTHER/UNKNOWN.
The study was withdrawn due to lack of patients.
Phase II Obstructive Sleep Apnea trial by Duke University. Stop reason: OPERATIONAL.
Failure to secure funding
Unknown Ischemia trial by Duke University. Stop reason: OPERATIONAL.
Low accrual
Phase II Carcinoma, Non-Small-Cell Lung trial by Duke University. Stop reason: OPERATIONAL.
Lack of accrual, study closed.