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City of Hope Medical Center clinical trial failures
Review 57 stopped clinical trials from City of Hope Medical Center, including disease areas, phases, and classified stop reasons.
This page groups real ClinicalTrials.gov-derived stopped trial records. The strongest added signal is the stop-reason classification: 8 of these records are likely biological failure signals, while the rest may reflect operational, strategic, regulatory, funding, enrollment, or unclear stop reasons.
Dominant stop reasons
- OTHER/UNKNOWN
- 25
- OPERATIONAL
- 24
- EFFICACY/FUTILITY
- 4
- SAFETY
- 4
Notable sponsors
- City of Hope Medical Center
- 57
Related phases
- Phase I
- 33
- Phase II
- 16
- Unknown
- 4
- Early Phase I
- 2
- Phase III
- 2
Crawlable stopped-trial records
Open ExploreShowing up to 57 representative records from this slice. Each link opens the trial detail page with source attribution and stop-reason context.
Phase I Recurrent Plasma Cell Myeloma trial by City of Hope Medical Center. Stop reason: OPERATIONAL.
Slow/Low Accrual
Phase I Acute Lymphoblastic Leukemia trial by City of Hope Medical Center. Stop reason: OPERATIONAL.
Accrual goal
Phase I Recurrent Acute Myeloid Leukemia trial by City of Hope Medical Center. Stop reason: EFFICACY/FUTILITY.
Pending Interim Analysis
Phase I Stage III Pancreatic Cancer AJCC v8 trial by City of Hope Medical Center. Stop reason: OPERATIONAL.
Accrual Goal met
Phase I Distal Bile Duct Adenocarcinoma trial by City of Hope Medical Center. Stop reason: EFFICACY/FUTILITY.
Pending Interim analysis
Phase I Recurrent Acute Lymphoblastic Leukemia trial by City of Hope Medical Center. Stop reason: EFFICACY/FUTILITY.
Pending Interim Analysis
Phase I Breast Carcinoma trial by City of Hope Medical Center. Stop reason: OTHER/UNKNOWN.
Drug Availability --Investigational agent needs to undergo further quality testing.
Phase II Prostate Adenocarcinoma trial by City of Hope Medical Center. Stop reason: OTHER/UNKNOWN.
05/26/2026 DSMC: Delinquent PMT reporting.
Phase II Extensive Stage Small Cell Lung Carcinoma trial by City of Hope Medical Center. Stop reason: OPERATIONAL.
No patients enrolled
Phase II Chronic Lymphocytic Leukemia trial by City of Hope Medical Center. Stop reason: OTHER/UNKNOWN.
Resources
Phase I Advanced Cancer trial by City of Hope Medical Center. Stop reason: OTHER/UNKNOWN.
Drug Availability
Phase I Currently Only Enrolling Glioblastoma Patients at First Recurrence trial by City of Hope Medical Center. Stop reason: SAFETY.
Safety issues
Phase I Acute Myeloid Leukemia trial by City of Hope Medical Center. Stop reason: OPERATIONAL.
accrual goal
Phase II Recurrent Grade 1 Follicular Lymphoma trial by City of Hope Medical Center. Stop reason: EFFICACY/FUTILITY.
Pending Interim Analysis
Phase I Locally Advanced Cervical Carcinoma trial by City of Hope Medical Center. Stop reason: OTHER/UNKNOWN.
no resource
Phase I Myelodysplastic Syndrome/Acute Myeloid Leukemia trial by City of Hope Medical Center. Stop reason: OTHER/UNKNOWN.
resources
Phase I Chronic Graft Versus Host Disease trial by City of Hope Medical Center. Stop reason: OPERATIONAL.
pending funding
Unknown Breast Cancer-Related Lymphedema trial by City of Hope Medical Center. Stop reason: OPERATIONAL.
low accrual
Phase II Metastatic Lung Non-Small Cell Carcinoma trial by City of Hope Medical Center. Stop reason: OPERATIONAL.
no accrual
Phase I Recurrent Acute Myeloid Leukemia trial by City of Hope Medical Center. Stop reason: OTHER/UNKNOWN.
cprmc withdrawn
Phase I Platinum-Resistant Fallopian Tube Carcinoma trial by City of Hope Medical Center. Stop reason: OTHER/UNKNOWN.
Abandoned
Phase II Advanced Colon Adenocarcinoma trial by City of Hope Medical Center. Stop reason: OTHER/UNKNOWN.
Abandoned 9/23/24
Phase I Glioblastoma trial by City of Hope Medical Center. Stop reason: OPERATIONAL.
Funding
Phase I Acute Myeloid Leukemia trial by City of Hope Medical Center. Stop reason: OTHER/UNKNOWN.
Withdrawn -ctms
Early Phase I Breast Carcinoma trial by City of Hope Medical Center. Stop reason: OTHER/UNKNOWN.
withdrawn
Phase I Recurrent B-Cell Non-Hodgkin Lymphoma trial by City of Hope Medical Center. Stop reason: OPERATIONAL.
no accrual
Phase I Adult Acute Myeloid Leukemia in Remission trial by City of Hope Medical Center. Stop reason: SAFETY.
Unable to safely escalate to TMLI doses that were hypothesized to be effective and less toxic than FTBI. Likely due to the giving of Busulfan prior to radiation delivery. Therefore, the study was abandoned and no further patients were accrued.
Early Phase I Metastatic Malignant Solid Neoplasm trial by City of Hope Medical Center. Stop reason: OTHER/UNKNOWN.
withdrawn per PI
Phase I Brain and Central Nervous System Tumors trial by City of Hope Medical Center. Stop reason: OTHER/UNKNOWN.
Terminated early due a shift in resources after lackluster performance of the drug.
Phase I Recurrent Follicular Lymphoma trial by City of Hope Medical Center. Stop reason: OPERATIONAL.
Feasibility
Phase I Hematopoietic and Lymphoid Cell Neoplasm trial by City of Hope Medical Center. Stop reason: OPERATIONAL.
slow accruals
Phase I Recurrent Acute Myeloid Leukemia trial by City of Hope Medical Center. Stop reason: OTHER/UNKNOWN.
Drug availability
Phase I Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities trial by City of Hope Medical Center. Stop reason: OPERATIONAL.
Due to the budget issues, the study discontinued at Phase II.
Phase II Esophageal Squamous Cell Carcinoma trial by City of Hope Medical Center. Stop reason: SAFETY.
Safety concerns
Phase II Acute Biphenotypic Leukemia trial by City of Hope Medical Center. Stop reason: OTHER/UNKNOWN.
RSS recommendation
Unknown Severe Hemophilia A trial by City of Hope Medical Center. Stop reason: OTHER/UNKNOWN.
complete per PI
Unknown Estrogen Receptor-positive Breast Cancer trial by City of Hope Medical Center. Stop reason: OTHER/UNKNOWN.
Study closed after it became too difficult to interest patients in participating.
Phase II Smoldering Plasma Cell Myeloma trial by City of Hope Medical Center. Stop reason: OPERATIONAL.
Budget issues
Phase II Iron Overload trial by City of Hope Medical Center. Stop reason: OPERATIONAL.
Low enrollment
Phase I CD30-Positive Neoplastic Cells Present trial by City of Hope Medical Center. Stop reason: OTHER/UNKNOWN.
contract not executed
Phase III Prostate Cancer trial by City of Hope Medical Center. Stop reason: OPERATIONAL.
Accrual too slow
Phase I Plasma Cell Leukemia trial by City of Hope Medical Center. Stop reason: OPERATIONAL.
Budgetary constraints
Phase I Hematopoietic and Lymphoid Cell Neoplasm trial by City of Hope Medical Center. Stop reason: OPERATIONAL.
Administratively withdrawn
Phase II Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive trial by City of Hope Medical Center. Stop reason: OTHER/UNKNOWN.
PI Withdrawal
Phase II Recurrent Colorectal Carcinoma trial by City of Hope Medical Center. Stop reason: OPERATIONAL.
Poor Accrual
Phase III Recurrent Diffuse Large B-Cell Lymphoma trial by City of Hope Medical Center. Stop reason: OTHER/UNKNOWN.
Withdrawal of sponsor support
Phase I Plasma Cell Leukemia in Remission trial by City of Hope Medical Center. Stop reason: OPERATIONAL.
Feasibility Issues
Phase I Breast Cancer trial by City of Hope Medical Center. Stop reason: OTHER/UNKNOWN.
Loss of principal investigator
Phase I Bile Duct Adenocarcinoma trial by City of Hope Medical Center. Stop reason: OTHER/UNKNOWN.
Company no longer interested in supporting this trial
Phase II Liver Cancer trial by City of Hope Medical Center. Stop reason: OPERATIONAL.
Due to Sorafenib became first line treatment for HCC, the designed treatment became less competitive. The company Sanofi decided not to continue to support
Phase I Acute Myeloid Leukemia in Remission trial by City of Hope Medical Center. Stop reason: OTHER/UNKNOWN.
The study design was revised so a new protocol will be opened.
Phase II Liver Metastases trial by City of Hope Medical Center. Stop reason: OPERATIONAL.
Slow accrual.
Phase II Lung Cancer trial by City of Hope Medical Center. Stop reason: OPERATIONAL.
Poor accrual
Phase II Pancreatic Cancer trial by City of Hope Medical Center. Stop reason: SAFETY.
Toxicity
Phase I Chronic Myeloproliferative Disorders trial by City of Hope Medical Center. Stop reason: OTHER/UNKNOWN.
Protocol objective could not be met. A new study with amended eligibility criteria will be developed.
Phase I Adult Liposarcoma trial by City of Hope Medical Center. Stop reason: OTHER/UNKNOWN.
Drug availability issues
Unknown Adult Supratentorial Primitive Neuroectodermal Tumor (PNET) trial by City of Hope Medical Center. Stop reason: OPERATIONAL.
No participants enrolled.