Sponsor hub
Brigham and Women's Hospital clinical trial failures
Review 68 stopped clinical trials from Brigham and Women's Hospital, including disease areas, phases, and classified stop reasons.
This page groups real ClinicalTrials.gov-derived stopped trial records. The strongest added signal is the stop-reason classification: 2 of these records are likely biological failure signals, while the rest may reflect operational, strategic, regulatory, funding, enrollment, or unclear stop reasons.
Dominant stop reasons
- OPERATIONAL
- 43
- OTHER/UNKNOWN
- 22
- EFFICACY/FUTILITY
- 2
- REGULATORY
- 1
Notable sponsors
- Brigham and Women's Hospital
- 68
Related phases
- Phase IV
- 20
- Phase II
- 19
- Unknown
- 12
- Early Phase I
- 6
- Phase III
- 6
Crawlable stopped-trial records
Open ExploreShowing up to 68 representative records from this slice. Each link opens the trial detail page with source attribution and stop-reason context.
Phase II Wound of Skin trial by Brigham and Women's Hospital. Stop reason: OPERATIONAL.
Due to the insufficient accrual rate and strategic reasons to focus our efforts on higher impact research projects.
Phase I Acute Respiratory Distress Syndrome trial by Brigham and Women's Hospital. Stop reason: OPERATIONAL.
Due to low enrollment, the study was halted early.
Unknown Hiv trial by Brigham and Women's Hospital. Stop reason: OPERATIONAL.
Study withdrawn prior to enrollment due to lack of funding.
Phase IV Palmoplantar Pustulosis trial by Brigham and Women's Hospital. Stop reason: OPERATIONAL.
Sponsor terminated funding
Phase II Transthyretin Amyloid Cardiopathy trial by Brigham and Women's Hospital. Stop reason: REGULATORY.
no subjects available
Phase II Amyloidosis trial by Brigham and Women's Hospital. Stop reason: OPERATIONAL.
recruitment of new patients not possible during Covid 19 epidemic
Phase IV Agitation trial by Brigham and Women's Hospital. Stop reason: OPERATIONAL.
Study did not start - due to funding issues prior to IRB approval
Phase IV Depression trial by Brigham and Women's Hospital. Stop reason: OPERATIONAL.
low enrollment
Phase II Painful Diabetic Neuropathy trial by Brigham and Women's Hospital. Stop reason: OTHER/UNKNOWN.
This study never left the planning stages: there was no IRB application and no participants were enrolled.
Phase IV Diabetes Mellitus, Type II trial by Brigham and Women's Hospital. Stop reason: OTHER/UNKNOWN.
No participants were enrolled in the trial.
Phase I Multiple Sclerosis trial by Brigham and Women's Hospital. Stop reason: OPERATIONAL.
The study was terminated without recruitment.
Early Phase I REM Behavior Disorder trial by Brigham and Women's Hospital. Stop reason: OTHER/UNKNOWN.
Study will not longer be done. Terminated due to sponsor noncompliance.
Phase II Opioid Use Disorder trial by Brigham and Women's Hospital. Stop reason: OPERATIONAL.
Low recruitment numbers and study funding will be closing shortly.
Phase II Alcohol Use Disorder trial by Brigham and Women's Hospital. Stop reason: OTHER/UNKNOWN.
After months of screening, we screened 175 individuals, only 3 were eligible, 2 declined, and 1 was moved to a different floor before study activities were able to take place.
Phase III Heart Failure trial by Brigham and Women's Hospital. Stop reason: OPERATIONAL.
Low feasibility of completion within the study period due to delayed site activation and slow participant accrual
Phase IV Opioid Use trial by Brigham and Women's Hospital. Stop reason: OPERATIONAL.
Due to limitations caused by COVID, enrollment targets could not be met.
Phase I Short Telomere Length trial by Brigham and Women's Hospital. Stop reason: OPERATIONAL.
Lack of financial support
Early Phase I Sleep Apnea trial by Brigham and Women's Hospital. Stop reason: OPERATIONAL.
Inability to recruit during COVID
Phase III Urinary Incontinence trial by Brigham and Women's Hospital. Stop reason: OPERATIONAL.
Lack of funds
Phase III Type 2 Diabetes trial by Brigham and Women's Hospital. Stop reason: OTHER/UNKNOWN.
Difficulty enrolling patients with elevated triglycerides under statin treatment
Unknown Pregnancy trial by Brigham and Women's Hospital. Stop reason: OPERATIONAL.
Study drug shortage, COVID related suspension of recruitment
Phase III COVID trial by Brigham and Women's Hospital. Stop reason: EFFICACY/FUTILITY.
Futility
Early Phase I Amputation, Traumatic trial by Brigham and Women's Hospital. Stop reason: OPERATIONAL.
No participants are currently receiving therapy under this protocol, funding is coming to an end and the PI is leaving the institution.
Phase IV Psoriasis trial by Brigham and Women's Hospital. Stop reason: OPERATIONAL.
The study was not funded.
Phase II Obesity trial by Brigham and Women's Hospital. Stop reason: OTHER/UNKNOWN.
International shortage of the chemical para-aminohippuric acid (PAH) due to manufacturing changes, led to inability to perform key measurements to meet trial objectives
Unknown Hypertension trial by Brigham and Women's Hospital. Stop reason: OPERATIONAL.
Not funded.
Early Phase I Hypersomnia trial by Brigham and Women's Hospital. Stop reason: OPERATIONAL.
Target study population was extremely difficult to recruit and planned study budget was exceeded
Unknown Actinic Keratosis trial by Brigham and Women's Hospital. Stop reason: OPERATIONAL.
The PI decided to not proceed with the trial due to lack of funding.
Early Phase I Microstomia trial by Brigham and Women's Hospital. Stop reason: OPERATIONAL.
PI no longer pursuing clinical trial
Phase II Postpartum Hemorrhage trial by Brigham and Women's Hospital. Stop reason: OPERATIONAL.
funding and manpower unavailable, completion within a reasonable timeframe not possible.
Phase II Major Depressive Disorder trial by Brigham and Women's Hospital. Stop reason: OTHER/UNKNOWN.
Study staff change.
Phase IV Low Birthweight trial by Brigham and Women's Hospital. Stop reason: OPERATIONAL.
Trial withdrawn due to COVID-19.
Phase IV Congestive Heart Failure trial by Brigham and Women's Hospital. Stop reason: OPERATIONAL.
Inadequate Recruitment
Phase IV Delirium in Old Age trial by Brigham and Women's Hospital. Stop reason: OTHER/UNKNOWN.
Never funded
Phase II Osteoarthritis trial by Brigham and Women's Hospital. Stop reason: OTHER/UNKNOWN.
A pilot study was negative.
Phase IV Pulmonary Arterial Hypertension trial by Brigham and Women's Hospital. Stop reason: OPERATIONAL.
Low enrollment
Phase IV Infertility trial by Brigham and Women's Hospital. Stop reason: OPERATIONAL.
Before enrollment, suspended due to changing insurance coverage of study drugs.
Phase II Major Depressive Disorder trial by Brigham and Women's Hospital. Stop reason: OPERATIONAL.
PI departure, slow recruitment
Phase IV Achilles Tendinopathy trial by Brigham and Women's Hospital. Stop reason: OPERATIONAL.
Insufficient recruitment
Unknown Preeclampsia trial by Brigham and Women's Hospital. Stop reason: OPERATIONAL.
Pending funding
Phase IV Heart Failure With Reduced Ejection Fraction trial by Brigham and Women's Hospital. Stop reason: OPERATIONAL.
Lost funding prior to study commencing
Phase IV Peripheral Artery Disease trial by Brigham and Women's Hospital. Stop reason: OPERATIONAL.
study was not funded
Phase I Chronic Obstructive Pulmonary Disease trial by Brigham and Women's Hospital. Stop reason: OPERATIONAL.
Funding ended prior to resolution of all equipment (polarizer) issues.
Phase IV Urinary Incontinence trial by Brigham and Women's Hospital. Stop reason: OTHER/UNKNOWN.
New department chairman instructed PI to discontinue study.
Unknown Insulin Sensitivity trial by Brigham and Women's Hospital. Stop reason: OTHER/UNKNOWN.
Study sponsor terminated study due to AE's reported with valsartan and aliskiren
Phase II Heart Failure trial by Brigham and Women's Hospital. Stop reason: OPERATIONAL.
No subjects were enrolled in this study. Funding ran out.
Phase II Anxiety Disorder trial by Brigham and Women's Hospital. Stop reason: OPERATIONAL.
Lack of funds and insufficient patient population for study enrollment.
Phase II Antibody-mediated Rejection trial by Brigham and Women's Hospital. Stop reason: EFFICACY/FUTILITY.
Lack of efficacy
Unknown Dialysis trial by Brigham and Women's Hospital. Stop reason: OPERATIONAL.
The study stopped due to lack of funding.
Phase II Carotid Stenosis trial by Brigham and Women's Hospital. Stop reason: OTHER/UNKNOWN.
PI moved to a new facility
Unknown Hypertension trial by Brigham and Women's Hospital. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Unknown Dialysis trial by Brigham and Women's Hospital. Stop reason: OPERATIONAL.
The funding source is not going to fund this anymore. Only two subjects completed the study therefore meaningful analysis not possible.
Phase IV Healthy trial by Brigham and Women's Hospital. Stop reason: OTHER/UNKNOWN.
Research question answered by another group of researchers (Sviggum et al)
Phase IV Chronic Obstructive Pulmonary Disease (COPD) trial by Brigham and Women's Hospital. Stop reason: OTHER/UNKNOWN.
Sponsor decided to stop the study due to expiration of blinded placebo .
Unknown Asthma trial by Brigham and Women's Hospital. Stop reason: OPERATIONAL.
Funding was terminated
Phase IV Diastolic Dysfunction trial by Brigham and Women's Hospital. Stop reason: OPERATIONAL.
Inadequate recruitment
Phase IV End Stage Renal Disease trial by Brigham and Women's Hospital. Stop reason: OPERATIONAL.
change of funding leading to major redesign
Phase IV Kidney Disease trial by Brigham and Women's Hospital. Stop reason: OTHER/UNKNOWN.
Novartis has have decided to terminate all clinical investigator-initiated research projects involving aliskiren
Unknown Transplant trial by Brigham and Women's Hospital. Stop reason: OPERATIONAL.
due to slow enrollment
Phase II Carotid Stenosis trial by Brigham and Women's Hospital. Stop reason: OPERATIONAL.
Slow enrollment
Phase I Chronic Obstructive Airway Disease trial by Brigham and Women's Hospital. Stop reason: OTHER/UNKNOWN.
the fellow interested in this project left the institution
Phase III Back Pain trial by Brigham and Women's Hospital. Stop reason: OTHER/UNKNOWN.
Company decided to discontinue
Phase II Vitamin D Deficiency trial by Brigham and Women's Hospital. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase II Patients With Acute Pancreatitis trial by Brigham and Women's Hospital. Stop reason: OPERATIONAL.
Investigator left institution
Phase III Delirium trial by Brigham and Women's Hospital. Stop reason: OPERATIONAL.
unable to enroll
Phase II Amyloidosis trial by Brigham and Women's Hospital. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Unknown Surgical Site Infection trial by Brigham and Women's Hospital. Stop reason: OTHER/UNKNOWN.
Another study with similar methods was recently published
Early Phase I Subarachnoid Hemorrhage trial by Brigham and Women's Hospital. Stop reason: OTHER/UNKNOWN.
Principle Investigator is moving to another institution and plans to restart this proctocol in the new location.