Alliance for Clinical Trials in Oncology clinical trial failures

Review 38 stopped clinical trials from Alliance for Clinical Trials in Oncology, including disease areas, phases, and classified stop reasons.

This page groups real ClinicalTrials.gov-derived stopped trial records. The strongest added signal is the stop-reason classification: 7 of these records are likely biological failure signals, while the rest may reflect operational, strategic, regulatory, funding, enrollment, or unclear stop reasons.

Total stopped trials38

Likely biological signals7

Shown below38

Dominant stop reasons

OTHER/UNKNOWN: 17
OPERATIONAL: 14
EFFICACY/FUTILITY: 5
SAFETY: 2

Notable sponsors

Alliance for Clinical Trials in Oncology: 38

Related phases

Phase II: 19
Phase III: 15
Phase I: 4

Crawlable stopped-trial records

Open Explore

Showing up to 38 representative records from this slice. Each link opens the trial detail page with source attribution and stop-reason context.

NCT06671912: Testing Low Dose Tamoxifen for Invasive Breast Cancer, LoTam Trial

Phase III Anatomic Stage 0 Breast Cancer AJCC v8 trial by Alliance for Clinical Trials in Oncology. Stop reason: OTHER/UNKNOWN.

Amending protocol to increase sample size

NCT04803201: Testing the Addition of Duvelisib or CC-486 to the Usual Treatment for Peripheral T-Cell Lymphoma

Phase II Angioimmunoblastic T-cell Lymphoma trial by Alliance for Clinical Trials in Oncology. Stop reason: EFFICACY/FUTILITY.

Interim Analysis

NCT02516423: Ixazomib Citrate, Lenalidomide, Dexamethasone, and Zoledronic Acid or Zoledronic Acid Alone After Radiation Therapy in Treating Patients With Solitary Plasmacytoma of Bone

Phase III Solitary Osseous Plasmacytoma trial by Alliance for Clinical Trials in Oncology. Stop reason: OPERATIONAL.

DSMB recommendation due to slow accrual

NCT05751668: Finding an Effective Dose of GM1 to Reduce or Prevent Neuropathy (Numbness or Weakness) Due to Treatment With Paclitaxel (Phase II)

Phase II Anatomic Stage IV Breast Cancer AJCC v8 trial by Alliance for Clinical Trials in Oncology. Stop reason: EFFICACY/FUTILITY.

Interim analysis

NCT03087708: Naloxegol in Treating Patients With Stage IIIB-IV Non-small Cell Lung Cancer

Phase II Stage IIIB Non-Small Cell Lung Cancer trial by Alliance for Clinical Trials in Oncology. Stop reason: OPERATIONAL.

Insufficient accrual

NCT03839940: Dexamethasone in Reducing Everolimus-Induced Oral Stomatitis in Patients With Cancer

Phase III Malignant Neoplasm trial by Alliance for Clinical Trials in Oncology. Stop reason: OPERATIONAL.

Severe lack of accrual

NCT01814813: Vaccine Therapy With Bevacizumab Versus Bevacizumab Alone in Treating Patients With Recurrent Glioblastoma Multiforme That Can Be Removed by Surgery

Phase II Recurrent Glioblastoma trial by Alliance for Clinical Trials in Oncology. Stop reason: EFFICACY/FUTILITY.

DSMB futility analysis

NCT02485834: FDG-PET Directed Treatment in Improving Response in Patients With Locally Advanced Stomach or Gastroesophageal Junction Cancer

Phase II Adenocarcinoma of the Gastroesophageal Junction trial by Alliance for Clinical Trials in Oncology. Stop reason: OPERATIONAL.

Poor accrual

NCT01167725: Standard Therapy With or Without Surgery and Mitomycin C in Treating Patients With Advanced Limited Peritoneal Dissemination of Colon Cancer

Phase III Colorectal Cancer trial by Alliance for Clinical Trials in Oncology. Stop reason: OTHER/UNKNOWN.

No stop-reason text available in the compact dataset.

NCT05677373: Testing the Safety and Effectiveness of Combining Two Drugs, PLX2853 and Trametinib in the Treatment of Advanced Uveal Melanoma

Phase I Advanced Uveal Melanoma trial by Alliance for Clinical Trials in Oncology. Stop reason: OTHER/UNKNOWN.

The drug company supporting this trial has withdrawn support, including the ability to provide study agent.

NCT02927249: Aspirin in Preventing Recurrence of Cancer in Patients With HER2 Negative Stage II-III Breast Cancer After Chemotherapy, Surgery, and/or Radiation Therapy

Phase III Node Positive HER2 Negative Breast Cancer trial by Alliance for Clinical Trials in Oncology. Stop reason: SAFETY.

DSMB review

NCT02490878: Corticosteroids + Bevacizumab vs. Corticosteroids + Placebo (BEST) for Radionecrosis After Radiosurgery for Brain Metastases

Phase II Radionecrosis trial by Alliance for Clinical Trials in Oncology. Stop reason: OPERATIONAL.

Slow accrual

NCT02856581: Management of Tobacco Treatment Intervention in Reducing Surgical Complications in Patients With Newly Diagnosed Lung Cancer Who Smoke Cigarettes

Phase III Lung Carcinoma trial by Alliance for Clinical Trials in Oncology. Stop reason: OPERATIONAL.

Slow accrual

NCT00513747: Early or Delayed Fludarabine and Rituximab in Treating Patients With Previously Untreated Chronic Lymphocytic Leukemia

Phase III Leukemia trial by Alliance for Clinical Trials in Oncology. Stop reason: OPERATIONAL.

Insufficient accrual

NCT00085449: Alemtuzumab Plus Fludarabine and Melphalan With or Without Cyclosporine, Mycophenolate Mofetil, and Low-Dose Total-Body Irradiation Therapy Followed by Donor Peripheral Stem Cell Transplant in Treating Patients With Hematologic Cancer

Phase I Leukemia trial by Alliance for Clinical Trials in Oncology. Stop reason: OPERATIONAL.

Funding cut, no patients enrolled

NCT01041781: Gemcitabine Hydrochloride or Pemetrexed Disodium and Carboplatin With or Without Celecoxib in Treating Patients With Advanced Non-Small Cell Lung Cancer

Phase III Lung Cancer trial by Alliance for Clinical Trials in Oncology. Stop reason: SAFETY.

DSMB recommendation

NCT00077233: FOLFIRI or FOLFOX With or Without Cetuximab in Patients With Metastatic Adenocarcinoma of the Colon or Rectum

Phase III Colorectal Cancer trial by Alliance for Clinical Trials in Oncology. Stop reason: OPERATIONAL.

Poor accrual

NCT01279681: Combination Chemotherapy Plus Bevacizumab With or Without Oxaliplatin in Treating Older Patients With Metastatic Colorectal Cancer

Phase III Cognitive/Functional Effects trial by Alliance for Clinical Trials in Oncology. Stop reason: OPERATIONAL.

Slow accrual

NCT00903396: Palonosetron Hydrochloride in Preventing Nausea and Vomiting Caused by Radiation Therapy in Patients With Primary Abdominal Cancer

Phase II Anal Cancer trial by Alliance for Clinical Trials in Oncology. Stop reason: OPERATIONAL.

Slow accrual

NCT01017601: Seneca Valley Virus-001 After Chemotherapy in Treating Patients With Extensive-Stage Small Cell Lung Cancer

Phase II Lung Cancer trial by Alliance for Clinical Trials in Oncology. Stop reason: EFFICACY/FUTILITY.

Interim analysis declared futility.

NCT00588900: Irinotecan and Cediranib in Treating Patients With Metastatic Colorectal Cancer That Did Not Respond to Previous Oxaliplatin, Fluoropyrimidine, and Bevacizumab

Phase II Colorectal Cancer trial by Alliance for Clinical Trials in Oncology. Stop reason: OTHER/UNKNOWN.

No stop-reason text available in the compact dataset.

NCT00863512: Chemotherapy or Observation in Treating Patients With Early Stage Non-Small Cell Lung Cancer

Phase III Lung Cancer trial by Alliance for Clinical Trials in Oncology. Stop reason: OTHER/UNKNOWN.

No stop-reason text available in the compact dataset.

NCT01118013: Donor Stem Cell Transplant in Treating Patients With Relapsed Hematologic Malignancies or Secondary Myelodysplasia Previously Treated With High-Dose Chemotherapy and Autologous Stem Cell Transplant

Phase II Leukemia trial by Alliance for Clinical Trials in Oncology. Stop reason: OTHER/UNKNOWN.

No stop-reason text available in the compact dataset.

NCT00045591: Celecoxib in Treating Women With Metastatic or Recurrent Breast Cancer

Phase II Breast Cancer trial by Alliance for Clinical Trials in Oncology. Stop reason: OTHER/UNKNOWN.

No stop-reason text available in the compact dataset.

NCT00081224: Neoadjuvant Celecoxib and Capecitabine Combined With Pelvic Irradiation in Treating Patients With Stage II or Stage III Adenocarcinoma (Cancer) of the Rectum

Phase II Colorectal Cancer trial by Alliance for Clinical Trials in Oncology. Stop reason: OTHER/UNKNOWN.

No stop-reason text available in the compact dataset.

NCT00068666: Temozolomide and Radiation Therapy in Treating Patients With Stage IV Malignant Melanoma With Measurable and Unresectable Cancer of the Central Nervous System

Phase II Melanoma (Skin) trial by Alliance for Clinical Trials in Oncology. Stop reason: OTHER/UNKNOWN.

No stop-reason text available in the compact dataset.

NCT00450515: Vinflunine and Capecitabine in Treating Patients With Previously Treated Metastatic Breast Cancer

Phase II Breast Cancer trial by Alliance for Clinical Trials in Oncology. Stop reason: OTHER/UNKNOWN.

Study was dropped prior to opening.

NCT00104754: Liposomal SN-38 in Treating Patients With Small Cell Lung Cancer

Phase II Lung Cancer trial by Alliance for Clinical Trials in Oncology. Stop reason: OTHER/UNKNOWN.

No stop-reason text available in the compact dataset.

NCT00003858: Mitoxantrone Following Surgery in Treating Patients With Prostate Cancer at High Risk for Recurrence

Phase II Prostate Cancer trial by Alliance for Clinical Trials in Oncology. Stop reason: OTHER/UNKNOWN.

The study was not activated.

NCT00053339: Trastuzumab With or Without Tamoxifen in Treating Women With Progressive Stage IV Breast Cancer

Phase III Stage IV Breast Cancer trial by Alliance for Clinical Trials in Oncology. Stop reason: OTHER/UNKNOWN.

The study was not activated.

NCT00041171: Docetaxel and St. John's Wort in Treating Patients With Solid Tumors That Cannot Be Removed By Surgery

Phase III Adult Solid Tumor trial by Alliance for Clinical Trials in Oncology. Stop reason: OTHER/UNKNOWN.

The study was not activated.

NCT00268437: Radiation Therapy, Pemetrexed Disodium, and Carboplatin in Treating Patients With Locally Advanced Esophageal Cancer That Can Be Removed By Surgery

Phase II Esophageal Cancer trial by Alliance for Clinical Trials in Oncology. Stop reason: EFFICACY/FUTILITY.

Trial closed early because, during an interim analysis, the primary endpoint fell short.

NCT00951444: Gemcitabine Hydrochloride and Carboplatin With or Without MK-0646 as First-Line Therapy in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer

Phase II Lung Cancer trial by Alliance for Clinical Trials in Oncology. Stop reason: OTHER/UNKNOWN.

The study was not activated.

NCT00571740: Cetuximab and Bevacizumab as First-Line Therapy Followed By Combination Chemotherapy and Bevacizumab With or Without Cetuximab as Second-Line Therapy in Treating Patients With Stage IV Colorectal Cancer

Phase II Colorectal Cancer trial by Alliance for Clinical Trials in Oncology. Stop reason: OTHER/UNKNOWN.

The study was not activated

NCT00004933: Homoharringtonine Compared With Hydroxyurea for Chronic Myelogenous Leukemia That Has Not Responded to Interferon Alfa

Phase III Leukemia trial by Alliance for Clinical Trials in Oncology. Stop reason: OPERATIONAL.

Poor accrual

NCT00072215: Cisplatin and Ifosfamide Combined With Either Paclitaxel or Vinblastine in Treating Men With Progressive or Recurrent Metastatic Germ Cell Tumors

Phase III Extragonadal Germ Cell Tumor trial by Alliance for Clinical Trials in Oncology. Stop reason: OPERATIONAL.

poor accrual

NCT00004239: 506U78 in Treating Patients With Hematologic Cancer and Kidney or Liver Impairment

Phase I Chronic Myeloproliferative Disorders trial by Alliance for Clinical Trials in Oncology. Stop reason: OPERATIONAL.

poor accrual

NCT01473303: Combination Chemotherapy With or Without Ganitumab in Treating Patients With Previously Untreated Metastatic Pancreatic Cancer

Phase I Pancreatic Cancer trial by Alliance for Clinical Trials in Oncology. Stop reason: OTHER/UNKNOWN.

CALGB 81003 closed about a week after it was activated because of withdrawal of support. No patients were registered on this study.