Unknown clinical trial failures

Unknown Borderline Personality Disorder trial by Icahn School of Medicine at Mount Sinai. Stop reason: OPERATIONAL.

Study was halted during COVID pandemic. However, PI is currently reconnecting with a compounding pharmacy to re-establish supply of the oxytocin and updating cost estimates. We are hoping to resume the pilot work with oxytocin once it is clarified.

Unknown Diabetes Type 2 trial by Richmond Pharmacology Limited. Stop reason: EFFICACY/FUTILITY.

The study is being terminated early on the grounds of futility, as continuation of the study is no longer considered scientifically or operationally justified.

Unknown Heart Failure (for Example, Fluid Overload) trial by Nuwellis, Inc.. Stop reason: OPERATIONAL.

The study was stopped early due to slow enrollment and was a business decision. This decision was not based on any efficacy or safety concerns.

Unknown Sialorrhea True Bulbar Palsy Medullary Injury trial by houyajing. Stop reason: OTHER/UNKNOWN.

In accordance with the time-limit regulations for ethical review, since the ethical approval certificate of this study protocol has expired, I hereby formally apply for the withdrawal of this study from the clinical trial registration platform.

Unknown Prostate Cancer trial by University Hospital, Montpellier. Stop reason: OTHER/UNKNOWN.

Flaw in the analytical technique

Unknown Healthy trial by Centre Hospitalier Universitaire de Nīmes. Stop reason: OTHER/UNKNOWN.

20131209 Regulatory authorization is currently blocked at the ANSM.

Unknown Moderate to Severe Ulcerative Colitis trial by University Hospital, Clermont-Ferrand. Stop reason: OTHER/UNKNOWN.

We were able to test our hypothesis using the current data

Unknown Infertility trial by Centre Hospitalier Universitaire, Amiens. Stop reason: OPERATIONAL.

recruitement difficulties

Unknown Open-angle Glaucoma trial by Centre Hospitalier Universitaire, Amiens. Stop reason: OPERATIONAL.

recruitement difficulties

Unknown Cleft Palate trial by Centre Hospitalier Universitaire, Amiens. Stop reason: OPERATIONAL.

no participants enrolled

Unknown Complex Regional Pain Syndromes trial by McMaster University. Stop reason: OPERATIONAL.

Unable to recruit patients

Unknown Migraine trial by W.L.Gore & Associates. Stop reason: OPERATIONAL.

Dissatisfactory enrollment rate with no safety concerns

Unknown Advanced Solid Tumors trial by Grit Biotechnology. Stop reason: REGULATORY.

Due to procedural adjustments at the investigative site, domestic registration on the China health authority's platform must be finalized prior to re-submission on ClinicalTrials.gov. Therefore, we hereby withdraw the current submission.

Unknown Dental Anxiety trial by University Hospital, Strasbourg, France. Stop reason: OTHER/UNKNOWN.

inclusion challenges

Unknown Heat Stroke trial by Second Affiliated Hospital, School of Medicine, Zhejiang University. Stop reason: OTHER/UNKNOWN.

Terminated due to protocol amendment: intervention window changed from entire ED stay to first 2h after ED admission. Revised protocol will be registered separately.

Unknown Kidney Cancer trial by McMaster University. Stop reason: OPERATIONAL.

It was terminated because of poor recruitment rate.

Unknown Heart Failure With Reduced Ejection Fraction (HFrEF) trial by Ancora Heart, Inc.. Stop reason: OPERATIONAL.

Recruitment on hold pending modifications to the clinical investigation plan

Unknown Thoracic Injuries trial by University Hospital, Montpellier. Stop reason: OTHER/UNKNOWN.

changes in patient care that move them further away from the inclusion criteria

Unknown Solid Tumors trial by Guangzhou Bio-gene Technology Co., Ltd. Stop reason: OTHER/UNKNOWN.

Due to corporate strategic adjustment.

Unknown Colorectal Cancer (CRC) trial by Guangzhou Bio-gene Technology Co., Ltd. Stop reason: OTHER/UNKNOWN.

Due to corporate strategic adjustment.

Unknown Relapsed/Refractory Multiple Myeloma trial by Guangzhou Bio-gene Technology Co., Ltd. Stop reason: OTHER/UNKNOWN.

Due to corporate strategic adjustment.

Unknown Connective Tissue Diseases trial by Guangzhou Bio-gene Technology Co., Ltd. Stop reason: OTHER/UNKNOWN.

Due to corporate strategic adjustment.

Unknown Hepatitis C trial by Kirby Institute. Stop reason: OPERATIONAL.

The study was impacted by the COVID-19 pandemic. Once recruitment recommenced it remained slow. Removal of Sofosbuvir from the PBS November 2020 impacted recruitment into Cohort B. Study closed early on 15-Sep-26.

Unknown Rapid Sequence Induction trial by Centre Hospitalier Sud Francilien. Stop reason: OTHER/UNKNOWN.

rate of inclusion too low

Unknown Acute Myeloid Leukemia (AML) trial by Masonic Cancer Center, University of Minnesota. Stop reason: OTHER/UNKNOWN.

No longer a research question to answer.

Unknown Cardiovascular Diseases trial by University Hospital, Linkoeping. Stop reason: OTHER/UNKNOWN.

The study was terminated prematurely due to insufficient operational resources to continue trial conduct and completion. The decision was unrelated to safety concerns or study outcomes.

Unknown Rotator Cuff Tear trial by University of Southern California. Stop reason: OPERATIONAL.

Recruitment difficulties

Unknown Genitourinary Syndrome of Menopause (GSM) trial by NYU Langone Health. Stop reason: OTHER/UNKNOWN.

The study was placed on hold by the Sponsor for \~1 year. Given the prolonged hold and absence of participant activity, the study was closed.

Unknown Liver Cancer trial by RenJi Hospital. Stop reason: OTHER/UNKNOWN.

The study was terminated because the originally planned VIC-1911 dose-escalation scheme (100 mg, 150 mg, 200 mg BID) was scientifically unjustified, lacking prior clinical safety data to support such starting doses when combined with lenvatinib in HC

Unknown AL Amyloidosis trial by Institute of Hematology & Blood Diseases Hospital, China. Stop reason: OTHER/UNKNOWN.

The study protocol was withdrawn because, after modifications, the study transitioned from an Investigator-Initiated Trial (IIT) to an Investigational New Drug (IND) clinical trial. This change necessitated a multi-center approach.

Unknown Solid Tumor trial by Grit Biotechnology. Stop reason: OTHER/UNKNOWN.

The study was terminated from a business perspective.

Unknown Cystic Fibrosis trial by Cliniques universitaires Saint-Luc- Université Catholique de Louvain. Stop reason: OPERATIONAL.

No recruitement, no grant to support this study

Unknown Hiv trial by Brigham and Women's Hospital. Stop reason: OPERATIONAL.

Study withdrawn prior to enrollment due to lack of funding.

Unknown Adult trial by Grit Biotechnology. Stop reason: OTHER/UNKNOWN.

The study was terminated from a business perspective.

Unknown Adult trial by Grit Biotechnology. Stop reason: OTHER/UNKNOWN.

The study was terminated from a business perspective.

Unknown Adult trial by Grit Biotechnology. Stop reason: OTHER/UNKNOWN.

The study was terminated from a business perspective.

Unknown Chronic Pain trial by Massachusetts General Hospital. Stop reason: OPERATIONAL.

End of NIH funding

Unknown Fibromyalgia trial by Sana Health. Stop reason: OTHER/UNKNOWN.

Study cancelled

Unknown ACL Injury trial by Women's College Hospital. Stop reason: OTHER/UNKNOWN.

Since study conception and approval in 2018, we have shown that the analgesic benefit of an adductor canal block is not clinically significant in the setting of ACL reconstruction surgery of the knee.

Unknown COPD (Chronic Obstructive Pulmonary Disease) trial by Medical University of Bialystok. Stop reason: OPERATIONAL.

Recruitment was temporarily suspended pending additional funding and activation of additional study centers. The pilot phase has been completed and is currently being evaluated. The suspension was not related to safety concerns.

Unknown Hyperglycemia trial by University of Oklahoma. Stop reason: OPERATIONAL.

study terminated due to lack of enrollment

Unknown Dexmedetomidine trial by Tongji University. Stop reason: OPERATIONAL.

The study was terminated due to a strategic prioritization and realignment of the research and development portfolio by the study team.

Unknown Breast Cancer trial by University of Maryland, Baltimore. Stop reason: OPERATIONAL.

This study was terminated due to slow accrual, and this due to the changing practice patterns, and difficulties with insurance coverage for some of the study related tests, such as OncotypeDx.

Unknown Intra-Articular Fractures trial by Duke University. Stop reason: OPERATIONAL.

Low accrual

Unknown Growth Failure trial by University of California, Los Angeles. Stop reason: OPERATIONAL.

The sponsor has notified us that they are not funding the study

Unknown Ovarian Cancer trial by Peking Union Medical College Hospital. Stop reason: OTHER/UNKNOWN.

Results failed to achieve the anticipated effect.

Unknown Cutaneous Melanoma trial by OHSU Knight Cancer Institute. Stop reason: OPERATIONAL.

The study did not meet its accrual goals due to the departure of study personnel. Study team opted for a study closure due to loss of key personnel.

Unknown Osteoarthritis Thumb trial by Kettering Health Network. Stop reason: OPERATIONAL.

Due to lack of enrollment, challenging follow-up, and lack of funding.

Unknown Alcohol Dependence trial by University of Oklahoma. Stop reason: OPERATIONAL.

Recruitment barriers.

Unknown Gaucher Disease, Type 3 trial by Agyany Pharma LTD. Stop reason: OTHER/UNKNOWN.

Sponsor stopped the study

Unknown GVHD trial by Hackensack Meridian Health. Stop reason: OPERATIONAL.

Lack of Accrual

Unknown Spondyloarthritis trial by Assistance Publique - Hôpitaux de Paris. Stop reason: OPERATIONAL.

The study of the long term antibody response is no longer relative due to the introduction of Covid vaccine.

Unknown Nsclc trial by Centre Oscar Lambret. Stop reason: OTHER/UNKNOWN.

The number of recruted patient was not sufficient

Unknown Relapsed or Refractory Multiple Myeloma trial by Guangzhou Bio-gene Technology Co., Ltd. Stop reason: OTHER/UNKNOWN.

Due to corporate strategic adjustment.

Unknown Severe/Moderate Coronavirus trial by Assistance Publique - Hôpitaux de Paris. Stop reason: OTHER/UNKNOWN.

Abandonment of the study project

Unknown Palmoplantar Pustulosis trial by Peking University First Hospital. Stop reason: OTHER/UNKNOWN.

Terminated early due to lack of expected efficacy. Three participants were enrolled but none completed the study.

Unknown Pain Cancer trial by Universidad Europea de Canarias. Stop reason: OPERATIONAL.

Study not initiated prior to enrollment.

Unknown Surgery trial by The Cleveland Clinic. Stop reason: OPERATIONAL.

Study Sponsor Decision

Unknown Paraphilia trial by Assistance Publique - Hôpitaux de Paris. Stop reason: OTHER/UNKNOWN.

Change of sponsor

Unknown Overactive Bladder Syndrome trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.

Not funded by industry

Unknown Meningitis, Meningococcal trial by University Hospital Southampton NHS Foundation Trust. Stop reason: OPERATIONAL.

Recruitment was paused in March 2020 due to the COVID pandemic. An interim data analysis was conducted in 2021 which confirmed that sufficient data had been collected to meet the primary objective, therefore the study was terminated.

Unknown Refractory Myasthenia Gravis trial by Shenzhen MagicRNA Biotechnology Co., Ltd. Stop reason: OTHER/UNKNOWN.

Change of registrant

Unknown Periprosthetic Joint Infection trial by University of Maryland, Baltimore. Stop reason: OPERATIONAL.

No participants enrolled.

Unknown Stage III Non-small Cell Lung Cancer trial by Varian, a Siemens Healthineers Company. Stop reason: OTHER/UNKNOWN.

Shifting patterns of care for the target population.

Unknown Safety trial by Union Hospital, Tongji Medical College, Huazhong University of Science and Technology. Stop reason: OTHER/UNKNOWN.

R\&D strategy adjustment

Unknown MEN1 Gene Mutation trial by University Hospital, Basel, Switzerland. Stop reason: OPERATIONAL.

The study was prematurely terminated due to significant difficulties in recruiting participants, arising from the extremely rare nature of the targeted gene mutation.

Unknown Blood Loss trial by Baylor Research Institute. Stop reason: OTHER/UNKNOWN.

Difficulty in acquiring patients in a reasonable amount of time.

Unknown Irritable Bowel Syndrome trial by Washington University School of Medicine. Stop reason: OTHER/UNKNOWN.

Due to changes in trial personnel (co-investigator and research coordinator leaving the institution).

Unknown Obsessive-Compulsive Disorder trial by Shanghai Mental Health Center. Stop reason: OTHER/UNKNOWN.

Main trial terminated after pilot trial: full randomization proved infeasible for nonlocal participants; baseline symptom-based allocation added confounding variable; comparison with CBGT alone was deemed sufficient to assess SC-ICBT effectiveness

Unknown Disorder of Urinary Stent trial by Phoenix Children's Hospital. Stop reason: OPERATIONAL.

The study was withdrawn prior to IRB approval and prior to enrollment. The study was never opened, and no participants were enrolled.

Unknown Rotator Cuff Tendinopathy trial by Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute). Stop reason: OTHER/UNKNOWN.

No participants met eligibility and the study was closed.

Unknown Aortic Valve Stenosis trial by University Hospital, Strasbourg, France. Stop reason: OTHER/UNKNOWN.

authorization obsolete

Unknown Arterial Occlusion trial by University of California, Los Angeles. Stop reason: OPERATIONAL.

Initiating PI left our institution.

Unknown Arrhythmia trial by Universitair Ziekenhuis Brussel. Stop reason: OPERATIONAL.

not enough patients were recruited

Unknown Epicondylitis, Lateral Humeral trial by Centre Hospitalier Universitaire de Nīmes. Stop reason: OTHER/UNKNOWN.

Discontinuation of production of the investigational medicinal product (PRP)

Unknown Sarcoidosis trial by Kevin F. Gibson. Stop reason: OPERATIONAL.

Poor recruitment

Unknown Duchenne Muscular Dystrophy trial by Assistance Publique - Hôpitaux de Paris. Stop reason: OTHER/UNKNOWN.

Cancellation of financing by the financier.

Unknown Prostate Cancer trial by Oncology Institute of Southern Switzerland. Stop reason: OPERATIONAL.

Recruitment difficulty due to eligibility criteria.

Unknown Atrial Fibrillation trial by Brian O'Neill MD. Stop reason: OPERATIONAL.

Lack of Funding

Unknown Hepatocellular Carcinoma trial by University of Washington. Stop reason: OPERATIONAL.

Terminated due to low accrual in Cohort B. (Accrual goal for Cohort A was met.)

Unknown Gingival Recession trial by University of Southern California. Stop reason: OTHER/UNKNOWN.

The PI has left the organization

Unknown Chronic Low Back Pain trial by Johns Hopkins University. Stop reason: OPERATIONAL.

Change in protocol per FDA that required funding and logistics that could not be accommodated.

Unknown Postoperative Pain trial by Beijing Tiantan Hospital. Stop reason: SAFETY.

One case with postoperative subdural hematoma was reported to the Institutional Review Board and DMC. This study was suspended. The association with study interventions remained to be explored.

Unknown Depressive Disorder, Treatment-Resistant trial by The Royal's Institute of Mental Health Research. Stop reason: OPERATIONAL.

The study was terminated prematurely due to significant recruitment challenges.

Unknown Osteopenia trial by University Hospital, Strasbourg, France. Stop reason: OTHER/UNKNOWN.

No stop-reason text available in the compact dataset.

Unknown Head and Neck Cancer trial by Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University. Stop reason: OPERATIONAL.

funding

Unknown Fasciitis, Plantar trial by Edna Rath. Stop reason: OTHER/UNKNOWN.

Withdrawn as researcher left before data collection could be completed

Unknown Psychiatry trial by Centre Hospitalier Universitaire Dijon. Stop reason: OPERATIONAL.

because of the Covid pandemic, group meditation could not be carried out and was not repeated in the study.

Unknown Intermetatarsal Bursitis trial by Rigshospitalet, Denmark. Stop reason: OTHER/UNKNOWN.

The study was stopped due to health-related issues in the research group, that hindered inrolement of patients.

Unknown Breast Cancer-Related Lymphedema trial by City of Hope Medical Center. Stop reason: OPERATIONAL.

low accrual

Unknown Acute Exacerbation of Chronic Obstructive Pulmonary Disease trial by Hasselt University. Stop reason: OTHER/UNKNOWN.

The anticipated intervention could not be delivered due to low admission time

Unknown Frail Elderly Syndrome trial by Healeon Medical Inc. Stop reason: OPERATIONAL.

COVID -19 closed facility and testing of subjects

Unknown Interstitial Lung Disease trial by McGill University Health Centre/Research Institute of the McGill University Health Centre. Stop reason: OPERATIONAL.

Slow recruitment

Unknown Acute Lymphoblastic Leukemia trial by Children's Oncology Group. Stop reason: OTHER/UNKNOWN.

All potential pilot phase pts have been enrolled.

Unknown Esophageal Squamous Cell Carcinoma trial by Hebei Medical University Fourth Hospital. Stop reason: OPERATIONAL.

The primary reason for termination was difficulty in recruitment

Unknown Acute Migraine Headache trial by United States Naval Medical Center, Portsmouth. Stop reason: OPERATIONAL.

unable to recruit participants

Unknown Post Dural Puncture Headache trial by United States Naval Medical Center, Portsmouth. Stop reason: OPERATIONAL.

Study never initiated

Unknown Critical Illness trial by Hospices Civils de Lyon. Stop reason: SAFETY.

Data safety monitoring board decision

Unknown Molar Incisor Hypomineralization trial by Istanbul University. Stop reason: OTHER/UNKNOWN.

The dentist who was taking care of the study's patients stopped working for a while because she went on maternity leave.

Unknown Preterm Labor trial by Woman's. Stop reason: OTHER/UNKNOWN.

Investigative team moved institutions