Disease area hub
Ophthalmology clinical trial failures
Review 260 stopped ophthalmology clinical trials, including failure signals, sponsors, phases, and stop reasons from ClinicalTrials.gov records.
This page groups real ClinicalTrials.gov-derived stopped trial records. The strongest added signal is the stop-reason classification: 34 of these records are likely biological failure signals, while the rest may reflect operational, strategic, regulatory, funding, enrollment, or unclear stop reasons.
Dominant stop reasons
- OTHER/UNKNOWN
- 120
- OPERATIONAL
- 106
- EFFICACY/FUTILITY
- 22
- SAFETY
- 12
Notable sponsors
- Asociación para Evitar la Ceguera en México
- 14
- Novartis Pharmaceuticals
- 8
- Allergan
- 6
- Johns Hopkins University
- 6
- Laboratorios Sophia S.A de C.V.
- 5
Related phases
- Phase II
- 79
- Phase IV
- 63
- Phase III
- 49
- Phase I
- 46
- Unknown
- 20
Crawlable stopped-trial records
Open ExploreShowing up to 100 representative records from this slice. Each link opens the trial detail page with source attribution and stop-reason context.
Unknown Open-angle Glaucoma trial by Centre Hospitalier Universitaire, Amiens. Stop reason: OPERATIONAL.
recruitement difficulties
Phase III Central Retinal Artery Occlusion trial by University Hospital Tuebingen. Stop reason: EFFICACY/FUTILITY.
Stopped after prespecified interim analysis due to futility
Phase I Diabetic Macular Edema (DME) trial by BioCryst Pharmaceuticals. Stop reason: OPERATIONAL.
Strategic decision
Phase IV Dry Eye Disease (DED) trial by Medical University of Vienna. Stop reason: OTHER/UNKNOWN.
This study was not halted prematurely. This record represents a duplicate entry and has therefore been withdrawn. The correct and complete study information can be found under identifier NCT07007702.
Phase IV Glaucoma, Open-Angle trial by Laboratorios Sophia S.A de C.V.. Stop reason: OTHER/UNKNOWN.
For interests of sponsor.
Phase IV Dry Eye trial by Scripps Poway Eyecare and Optometry. Stop reason: OPERATIONAL.
investigator decision
Phase I Diabetic Macular Edema trial by Michelle Abou-Jaoude. Stop reason: OPERATIONAL.
Low recruitment outcome
Phase II Dry Age-related Macular Degeneration trial by Gyroscope Therapeutics Limited. Stop reason: EFFICACY/FUTILITY.
Terminated for interim analysis demonstrating futility (trial highly unlikely to meet efficacy outcome). The trial is not ending early because of medical problems or concerns.
Phase I Dry Age-related Macular Degeneration trial by Gyroscope Therapeutics Limited. Stop reason: EFFICACY/FUTILITY.
The study was terminated due to the interim analysis demonstrating lack of treatment efficacy.
Phase II Dry Age-related Macular Degeneration trial by Gyroscope Therapeutics Limited. Stop reason: EFFICACY/FUTILITY.
Terminated for interim analysis demonstrating futility (trial highly unlikely to meet efficacy outcome). The trial is not ending early because of medical problems or concerns.
Phase III Macular Telangiectasia trial by Centre Hospitalier Universitaire Dijon. Stop reason: OPERATIONAL.
very rare disease, many difficulties in recruiting patients, inclusion rate far too slow, making it impossible to meet the main objective within a reasonable timeframe. the sponsor therefore decided to stop the study.
Phase I Ocular Graft-versus-host Disease trial by Lubris Bio Pty Ltd. Stop reason: OTHER/UNKNOWN.
Efficacy signal substantial enough to more to larger study
Phase III Dry Eye Disease trial by Bausch & Lomb Incorporated. Stop reason: OPERATIONAL.
Business Decision
Phase III Retinal Telangiectasis trial by Fondation Ophtalmologique Adolphe de Rothschild. Stop reason: EFFICACY/FUTILITY.
Study futility based on the interim analysis
Phase I Glaucoma trial by Massachusetts Eye and Ear Infirmary. Stop reason: OPERATIONAL.
Low recruitment
Phase I Sjogren's Syndrome With Dry Eye trial by Lubris Bio Pty Ltd. Stop reason: OTHER/UNKNOWN.
Efficacy signal substantial enough to move to a larger sturdy
Phase IV Dry Eye trial by Tufts Medical Center. Stop reason: OPERATIONAL.
Recruitment difficulties (low accrual)
Phase III Glaucoma trial by University of Miami. Stop reason: OTHER/UNKNOWN.
No patients had abnormal PERG and could not be included in the first two arms from the baseline timepoint.
Phase III Neovascular Age-related Macular Degeneration trial by Opthea Limited. Stop reason: OTHER/UNKNOWN.
The primary endpoint was not achieved in the study.
Phase III Neovascular Age-related Macular Degeneration trial by Opthea Limited. Stop reason: OTHER/UNKNOWN.
The primary endpoint was not achieved in the study.
Phase I Primary Open-angle Glaucoma trial by EyeD Pharma. Stop reason: OTHER/UNKNOWN.
The study was terminated early due to the difficulties to enrol participant
Phase II Diabetic Macular Edema trial by Aviceda Therapeutics, Inc.. Stop reason: OPERATIONAL.
The trial was stopped early due to insufficient study drug supply and study funding constraints
Phase IV Airway Complication of Anaesthesia trial by Sun Yat-sen University. Stop reason: OTHER/UNKNOWN.
The study was proactively suspended to ensure alignment with all applicable regulatory filing procedures. This decision was made to maintain adherence to institutional and compliance standards prior to study initiation.
Phase IV Dry Eye trial by Oyster Point Pharma, Inc.. Stop reason: OTHER/UNKNOWN.
Internal strategy change. Not related to safety concerns.
Phase II Dry Eye Syndromes trial by Iacta Pharmaceuticals. Stop reason: SAFETY.
Unexpected adverse events were observed in a subset of patients on drug. In an over abundance of caution the study was terminated. All adverse events resolved with no sequelae.
Phase II Neovascular Age-related Macular Degeneration trial by University of Padova. Stop reason: OTHER/UNKNOWN.
new data from clinical trials
Phase II Age-Related Macular Degeneration trial by Cognition Therapeutics. Stop reason: OPERATIONAL.
The trial was closed as part of a strategic business decision.
Phase II Neovascular Age-Related Macular Degeneration trial by IVERIC bio, Inc.. Stop reason: OPERATIONAL.
Following Sponsor reassessment, OPH2004 enrollment was stopped to initiate a new Zimura wet AMD trial, OPH2007, for treatment-naïve patients. Thus, only one patient was enrolled into and completed Study OPH2004.
Phase III Primary Open-angle Glaucoma trial by Laboratorios Sophia S.A de C.V.. Stop reason: OPERATIONAL.
Sponsor's prerogative since initial purpose for study shifted according to business strategy.
Phase IV Dry Eye trial by University of Alabama at Birmingham. Stop reason: OPERATIONAL.
COVID disruptions to recruitment and study completion, unforeseen staffing and other issues
Phase IV Retinal Vein Occlusion trial by Wake Forest University Health Sciences. Stop reason: SAFETY.
IRB stopped study due to safety concerns. No further data collection and what has been collected is not appropriate for analysis.
Phase IV Eye Strain trial by Laboratorios Sophia S.A de C.V.. Stop reason: OPERATIONAL.
Sponsor's decision.
Phase IV Primary Open Angle Glaucoma trial by Sight Sciences, Inc.. Stop reason: OPERATIONAL.
Business decision by the Sponsor
Phase IV Dry Eye trial by Tufts Medical Center. Stop reason: OPERATIONAL.
Per sponsor decision due to lengthy enrollment period
Phase IV Tears trial by University of Miami. Stop reason: OPERATIONAL.
Patient recruitment shortage and study coordinator turnover
Phase I Macular Edema trial by GlaxoSmithKline. Stop reason: EFFICACY/FUTILITY.
The study was terminated as the study met the prespecified threshold for futility of less than (\<) 20 percentage (%), based on interim analysis (IA).
Phase III Macular Edema trial by Luigi Rondas. Stop reason: EFFICACY/FUTILITY.
Results of interim analysis: stop the trial due to one group being significantly different from the other three groups. Furthermore, shortage of study medication.
Phase III Age-Related Macular Degeneration trial by Ophthotech Corporation. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase III Age-Related Macular Degeneration trial by Ophthotech Corporation. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase III Age-Related Macular Degeneration trial by Ophthotech Corporation. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase II Age-Related Macular Degeneration trial by Ophthotech Corporation. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase IV Neovascular (Wet) Age-related Macular Degeneration trial by Bayer. Stop reason: OPERATIONAL.
Study terminated due to administrative reasons not related to efficacy or safety.
Phase I Leber Congenital Amaurosis 10 trial by Laboratoires Thea. Stop reason: OPERATIONAL.
Terminated \[Study prematurely terminated due to sponsor decision for reasons unrelated to safety\]
Phase II Diabetic Macular Oedema trial by Belfast Health and Social Care Trust. Stop reason: OTHER/UNKNOWN.
Expiry of study drug - no replacement available.
Early Phase I Retinal Detachment trial by University of Wisconsin, Madison. Stop reason: OTHER/UNKNOWN.
Treatment approach changed, and insufficient population
Phase IV Glaucoma, Open-Angle trial by CT Glaucoma Associates. Stop reason: OPERATIONAL.
The 95% confidence interval for non-inferiority was met before planned enrollment was reached.
Phase III Diabetic Macular Edema trial by Kodiak Sciences Inc. Stop reason: EFFICACY/FUTILITY.
Study did not meet primary endpoint
Phase III Diabetic Macular Edema trial by Kodiak Sciences Inc. Stop reason: EFFICACY/FUTILITY.
Study did not meet primary endpoint
Phase IV Glaucoma trial by Nova Scotia Health Authority. Stop reason: OTHER/UNKNOWN.
Did not submit to the REB
Phase IV Glaucoma trial by Nova Scotia Health Authority. Stop reason: OTHER/UNKNOWN.
No REB file
Phase II Retinitis Pigmentosa trial by Laboratoires Thea. Stop reason: OPERATIONAL.
Business decision
Phase II Wet Macular Degeneration trial by Kodiak Sciences Inc. Stop reason: EFFICACY/FUTILITY.
Primary Endpoint Not Met
Phase II Retinitis Pigmentosa trial by Laboratoires Thea. Stop reason: OPERATIONAL.
Business decision
Phase III Primary Open Angle Glaucoma trial by Laboratorios Sophia S.A de C.V.. Stop reason: OPERATIONAL.
expiration time limit of recruitment
Phase IV Diabetic Macular Edema trial by Asociación para Evitar la Ceguera en México. Stop reason: OPERATIONAL.
Poor accrual
Phase III Cystoid Macular Edema trial by Asociación para Evitar la Ceguera en México. Stop reason: OPERATIONAL.
Poor accrual
Phase III Edema Macular trial by Asociación para Evitar la Ceguera en México. Stop reason: OPERATIONAL.
Poor accrual
Phase III Age Related Macular Degeneration trial by Asociación para Evitar la Ceguera en México. Stop reason: OPERATIONAL.
Poor accrual
Phase IV Diffuse Diabetic Macular Edema trial by Asociación para Evitar la Ceguera en México. Stop reason: OPERATIONAL.
Poor accrual
Phase II Retinal Detachment trial by Asociación para Evitar la Ceguera en México. Stop reason: OPERATIONAL.
Poor accrual
Phase III Dry Eye trial by HanAll BioPharma Co., Ltd.. Stop reason: OPERATIONAL.
Logistical issue
Phase II Age Related Macular Degeneration trial by Asociación para Evitar la Ceguera en México. Stop reason: OTHER/UNKNOWN.
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Phase IV Macular Edema trial by Asociación para Evitar la Ceguera en México. Stop reason: OTHER/UNKNOWN.
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Phase II Age Related Macular Degeneration trial by Asociación para Evitar la Ceguera en México. Stop reason: OTHER/UNKNOWN.
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Phase II Macular Thickening trial by Asociación para Evitar la Ceguera en México. Stop reason: OTHER/UNKNOWN.
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Phase IV Macular Edema trial by Asociación para Evitar la Ceguera en México. Stop reason: OTHER/UNKNOWN.
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Phase IV Macular Edema trial by Asociación para Evitar la Ceguera en México. Stop reason: OTHER/UNKNOWN.
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Phase III Diffuse Diabetic Macular Edema trial by Asociación para Evitar la Ceguera en México. Stop reason: OTHER/UNKNOWN.
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Phase III Macular Hole trial by Asociación para Evitar la Ceguera en México. Stop reason: OTHER/UNKNOWN.
Undefined
Phase I Ocular Hypertension trial by JeniVision, Inc.. Stop reason: OTHER/UNKNOWN.
Awaiting transition to Part 2
Phase II Age Related Macular Degeneration trial by Snyder, Robert W., M.D., Ph.D., P.C.. Stop reason: OPERATIONAL.
Lack of funding required for enrollment to reach statistical significance.
Phase II Dry Eye trial by ORA, Inc.. Stop reason: OPERATIONAL.
Study terminated by Sponsor
Phase I Dry Age Related Macular Degeneration trial by CHABiotech CO., Ltd. Stop reason: OPERATIONAL.
Sponsor decision
Phase II Macular Degeneration, Age-Related trial by Genentech, Inc.. Stop reason: OTHER/UNKNOWN.
The benefit to risk balance did not support further treatment with galegenimab (FHTR2163).
Phase I Neovascular Age-Related Macular Degeneration (nAMD) trial by AsclepiX Therapeutics, Inc.. Stop reason: SAFETY.
Adverse Events
Phase IV Exudative Age Related Macular Degeneration trial by Wake Forest University Health Sciences. Stop reason: SAFETY.
IRB stopped study due to safety concerns before any participants were enrolled.
Phase I Diabetic Macular Edema (DME) trial by AsclepiX Therapeutics, Inc.. Stop reason: SAFETY.
Adverse Events
Phase I Wet Age-related Macular Degeneration trial by Kodiak Sciences Inc. Stop reason: OTHER/UNKNOWN.
All patients past planned primary endpoint; decision by Sponsor to wind down open-label follow-up activities.
Phase IV Dry Eye trial by Johns Hopkins University. Stop reason: OPERATIONAL.
The study was terminated prematurely due to administrative reasons; loss of several research personnel. Because of strict eligibility criteria, the investigators anticipated delays in completing enrollment and therefore decided to terminate early.
Phase II Age-related Macular Degeneration trial by Ophthotech Corporation. Stop reason: OTHER/UNKNOWN.
No stop-reason text available in the compact dataset.
Phase IV Glaucoma trial by The New York Eye Surgery Center. Stop reason: OPERATIONAL.
COVID-19 challenges to recruitment
Phase III Age-related Macular Degeneration trial by St. Erik Eye Hospital. Stop reason: OTHER/UNKNOWN.
Lucentis, a treatment superior to PDT, has become available i Sweden.
Phase III Neovascular Age-Related Macular Degeneration trial by Hoffmann-La Roche. Stop reason: EFFICACY/FUTILITY.
Roche/Genentech has initiated an immediate pause of all new PDS implantations because the implants from commercial supply in the clinical studies did not meet the filed specifications for the intended use
Phase II Dry Eye Disease trial by Kiora Pharmaceuticals, Inc.. Stop reason: OTHER/UNKNOWN.
Study halted prematurely but potentially will resume
Phase IV Glaucoma Open-Angle Primary trial by University of California, Los Angeles. Stop reason: OPERATIONAL.
Problems unique to COVID-19, incomplete data due to a high rate of dropout to minimize non-essential appointments and difficult subject recruitment
Phase II Glaucoma trial by University of Nebraska. Stop reason: SAFETY.
Study stopped and data not analyzed
Phase IV Dry Eye trial by Vishal Jhanji. Stop reason: OPERATIONAL.
No participants were enrolled. Study never started.
Phase IV Intraocular Pressure trial by Alcon Research. Stop reason: OTHER/UNKNOWN.
difficulty of enrolling patients
Phase II Macular Degeneration, Age-Related trial by Genentech, Inc.. Stop reason: OTHER/UNKNOWN.
The benefit to risk balance did not support further treatment with galegenimab (FHTR2163).
Phase IV Eyelid Diseases trial by University of Miami. Stop reason: OPERATIONAL.
Research team dissembled because of no funding.
Phase I Macular Degeneration trial by Boehringer Ingelheim. Stop reason: SAFETY.
The trial was discontinued in the interests of patients considering benefit/risk balance.
Phase IV Retinal Detachment trial by Midwest Eye Institute. Stop reason: OPERATIONAL.
Poor enrollment
Phase II Diabetic Macular Edema trial by University of Nebraska. Stop reason: OPERATIONAL.
Funding lost and study never started
Unknown Diabetic Macular Oedema trial by PolyPhotonix Medical. Stop reason: OPERATIONAL.
Major protocol deviations compromised the study.
Phase II Ocular Graft-versus-host Disease trial by Washington University School of Medicine. Stop reason: OTHER/UNKNOWN.
Investigator decided to close study
Unknown Glaucoma trial by University of California, San Francisco. Stop reason: OTHER/UNKNOWN.
The necessary ethical approvals were not obtained in a timely manner.
Phase IV Dry Eye trial by Bucci Laser Vision Institute. Stop reason: OPERATIONAL.
Administrative
Phase I Neovascular Age-related Macular Degeneration trial by Innovent Biologics (Suzhou) Co. Ltd.. Stop reason: OPERATIONAL.
Company strategy adjustment
Phase IV Ocular Rosacea trial by Eye Associates of Central Texas. Stop reason: OPERATIONAL.
Lack of patient enrollment
Phase II Dry Eye trial by University of Illinois at Chicago. Stop reason: OPERATIONAL.
Study not initiated.